Selenium Status and Cardiovascular Disease: Dutch Epidemiologic Data (original) (raw)

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Abstract

Several mechanisms have been suggested which link selenium to myocardial ischemia (Salonen 1987). The antioxidant hypothesis is most popular and quite well established by experimental studies. A decreased glutathione peroxidase (GSH-Px) activity due to selenium deficiency may result in an accumulation of hydroperoxides. These peroxides may damage arterial endothelium and thus accelerate coronary atherosclerosis. On the other hand, platelet aggregation may be increased, resulting in an increased risk of coronary thrombosis. Other mechanisms probably not mediated by GSH-Px such as increased sensitivity to catecholamines, lower protection against heavy metals, and lower calcium transport, and their influence on blood pressure, thrombosis and atherosclerosis are more speculative.

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Authors and Affiliations

1. Department of Epidemiology, Erasmus University Medical School, Rotterdam, The Netherlands
   F. J. Kok & A. Hofman
2. Department of Human Nutrition, TNO-CIVO Toxicology and Nutrition Institute, P.O. Box 360, 3700 AJ, Zeist, The Netherlands
   F. J. Kok

Authors

1. F. J. Kok
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2. A. Hofman
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Editors and Affiliations

1. Fakultät für Biologie, Universität Konstanz, Postfach 5560, 7750, Konstanz, Germany
   Albrecht Wendel

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© 1989 Springer-Verlag Berlin Heidelberg

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Kok, F.J., Hofman, A. (1989). Selenium Status and Cardiovascular Disease: Dutch Epidemiologic Data. In: Wendel, A. (eds) Selenium in Biology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74421-1\_41

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• DOI: https://doi.org/10.1007/978-3-642-74421-1\_41
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