The effects of chlorpromazine on psychomotor stimulant self-administration in the Rhesus monkey (original) (raw)

Abstract

The effects of acute and chronic chlorpromazine treatment on psychomotor stimulant self-administration behavior in the Rhesus monkey were determined. Chlorpromazine treatment significantly increased the frequency of self-administration of cocaine, pipradrol, phenmetrazine, _d_-amphetamine and methylphenidate. The basis of this effect was thought to either be due to an antagonism of the reinforcing effect of these compounds or an antagonism of those actions of the psychomotor stimulants which may function in limiting their self-administration.

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Author notes

1. M. C. Wilson
   Present address: Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi
2. C. R. Schuster
   Present address: Department of Psychiatry, University of Chicago, Chicago, Illinois

Authors and Affiliations

1. Pharmacology Department, University of Michigan, Medical School, Ann Arbor, Michigan
   M. C. Wilson & C. R. Schuster

Authors

1. M. C. Wilson
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2. C. R. Schuster
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Additional information

This study was supported by NIMH Grant No. 5r-10MH-12084 and by NIMH Grant No. MH-18245-01.

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Wilson, M.C., Schuster, C.R. The effects of chlorpromazine on psychomotor stimulant self-administration in the Rhesus monkey.Psychopharmacologia 26, 115–126 (1972). https://doi.org/10.1007/BF00422098

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• Received: 01 April 1971
• Revised: 21 December 1971
• Issue Date: June 1972
• DOI: https://doi.org/10.1007/BF00422098

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