Effects of dopamine receptor blockade on alimentary behaviors: Home cage food consumption, magazine training, operant acquisition, and performance (original) (raw)
Abstract
Administration of the dopamine receptor blocker pimozide (1.0 mg/kg) disrupted the initiation, but not the maintenance, of home cage food consumption. Likewise, the number of pellets consumed during magazine training was decreased among pimozide-treated rats during the first, but not the second day of training. The acquisition of a bar-press response for food reinforcement (using a retractable bar) was severely retarded by pimozide. However, such an impairment was not evident if animals initially received 2 training days in the absence of the drug. Further, among rats trained to bar press to asymptote using a nonretractable bar, pimozide reduced the within and between days bar-press rate such that performance was indistinguishable from that of animals placed on extinction in the absence of the drug treatment. When transferred from the pimozide treatment to extinction in the absence of drug, the response rate increased to the level observed during the first session of either extinction or pimozide in the continuous reinforcement condition. The results are discussed in terms of sensory-motor and reinforcement consequences of dopamine receptor blockade.
Access this article
Subscribe and save
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime Subscribe now
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Similar content being viewed by others
References
- Anisman, H., Rémington, G., Sklar, L. S.: Effects of inescapable shock on subsequent escape performance: Catecholaminergic and cholinergic mediation of response initiation and maintenance. Psychopharmacology 61, 107–124 (1979)
Google Scholar - Fibiger, H. C.: Drugs and reinforcement mechanisms: A critical review of the catecholamine theory. Annu. Rev. Pharmacol. Toxicol. 18, 37–51 (1978)
Google Scholar - Fibiger, H. C., Zis, A. P., Phillips, G.: Haloperidol-induced disruption of conditioned avoidance responding: Attenuation by prior training or by anticholinergic drugs. Eur. J. Pharmacol. 30, 309–314 (1975)
Google Scholar - Fouriezos, G., Wise, R. A.: Pimozide-induced extinction of intractranial self-stimulation: Response patterns rule out motor or performance deficits. Brain Res. 103, 377–380 (1976)
Google Scholar - Marshall, J. F., Levitan, D., Stricker, E. M.: Activation-induced restoration of sensory-motor functions in rats with dopamine-depleting brain lessions. J. Comp. Physiol. Psychol. 90, 536–546 (1976)
Google Scholar - Wise, R. A.: Catecholamine theories of reward: A critical review. Brain Res. 152, 215–247 (1978)
Google Scholar - Wise, R. A., Yokel, R. A., Hansson, R. A., Gerber, G. J.: Concurrent intracranial self-stimulation and intravenous amphetamine self-administration in rats. Pharmacol. Biochem. Behav. 7, 459–461 (1977)
Google Scholar - Wise, R. A., Spindler, J., deWit, H., Gerber, G.: Neuroleptic-induced “anhedonia” in rats: Pimozide blocks the reward quality of food. Science 201, 262–264 (1978)
Google Scholar - Yokel, R. A., Pickens, R.: Extinction responding following amphetamine self-administration determination of reinforcement magnitude. Physiol. Psychol. 4, 39–42 (1976)
Google Scholar - Yokel, R. A., Wise, R. A.: Increased lever pressing for amphetamine after pimozide in rats: Implications for a dopamine theory of reward. Science 187, 547–549 (1975)
Google Scholar
Author information
Authors and Affiliations
- Department of Psychology, Carleton University, Ottawa, Canada
Tom N. Tombaugh, Jo Tombaugh & Hymie Anisman
Authors
- Tom N. Tombaugh
You can also search for this author inPubMed Google Scholar - Jo Tombaugh
You can also search for this author inPubMed Google Scholar - Hymie Anisman
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Tombaugh, T.N., Tombaugh, J. & Anisman, H. Effects of dopamine receptor blockade on alimentary behaviors: Home cage food consumption, magazine training, operant acquisition, and performance.Psychopharmacology 66, 219–225 (1979). https://doi.org/10.1007/BF00428309
- Received: 20 March 1979
- Accepted: 17 July 1979
- Issue Date: December 1979
- DOI: https://doi.org/10.1007/BF00428309