Effects of pimozide on nondiscriminated and discriminated performance in the pigeon (original) (raw)
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Abstract
The effects of pimozide (0.06, 0.18, 0.30 mg/kg), a dopamine receptor blocker, on nondiscriminated and discriminated performance were assessed in pigeons using a Latin Square design. In Experiment 1 a dose-dependent decrease in responding was observed with a variable interval 3-min schedule of reinforcement. More detailed analyses showed that total response rate, running respose rate, and post-reinforcement pause all showed the same dosedependent relationship. In Experiment 2 a successive discrimination task was employed to determine if pimozide affects a previously learned association between environmental stimuli. Each pigeon was first trained on the discrimination and then injected with the same doses as in Experiment 1. Although pimozide reduced responding in a dose-related fashion, a corresponding decrease in accuracy of responding was not evident. It was concluded that pimozide has a general response debilitating effect and that dopaminergic neurons probably are not involved in subserving associative processes.
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Authors and Affiliations
- Department of Psychology, Carleton University, K1S 5B6, Ottawa, Ontario, Canada
Tom N. Tombaugh
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- Tom N. Tombaugh
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Tombaugh, T.N. Effects of pimozide on nondiscriminated and discriminated performance in the pigeon.Psychopharmacology 73, 137–141 (1981). https://doi.org/10.1007/BF00429204
- Received: 19 February 1980
- Accepted: 24 October 1980
- Issue Date: April 1981
- DOI: https://doi.org/10.1007/BF00429204