The cytological distribution of ‘Osmiophilic Bodies’ in the normal and degenerating lateral geniculate nucleus of the monkey (original) (raw)

Summary

As a result of an electron-microscopic study of the distribution of ‘osmiophilic bodies’ in the lateral geniculate nucleus obtained from sixteen young monkeys the following conclusion are drawn.

1. 1. There are morphologically different types of osmiophilic bodies found in the lateral geniculate nucleus of the monkeys.
2. 1. The term ‘osmiophilic body’ seems to be inadequate and confusing in the midst of numerous light and electron-microscopical studies and it is suggested that it may be replaced by a more specific expression—applicable to only electronmicroscopy i.e. ‘electrondense’ bodies. In such cases it is essential to denote the topographical relations, if the exact source or chemical nature is uncertain.
3. 1. The possible relationship with the mitochondria has been discussed.
4. 1. As osmiophilic bodies within the mitochondria, in the immediate neighbourhood of the blood vessels, and in some of the glia cells have been observed only in the material obtained from the operated animals and not in the normal ‘controls’, a causal association with the pathological alteration is suggested.

Zusammenfassung

Als Ergebnis einer elektronenmikroskopischen Studie über die Verteilung der “osmiophilen Körperchen” im Corpus geniculatum laterale (Cgl) von 16 jungen Affen wurden folgende Schlüsse gezogen:

1. 1. Im Cgl der Affen finden sich verschiedene Arten osmiophiler Körperchen.
2. 1. Die Bezeichnung “osmiophile Körperchen” scheint angesichts zahlreicher licht- und elektronenoptischer Untersuchungen unpassend und verwirrend und sollte durch einen präziseren, auf die Elektronenmikroskopie anwendbaren Ausdruck, z. B. “elektronendichte” Körperchen ersetzt werden. Es ist wesentlich, die topographischen Beziehungen zu bezeichnen, wenn die genaue Herkunft oder chemische Natur ungewiß ist.
3. 1. Die mögliche Beziehung zu den Mitochondrien wird diskutiert.
4. 1. Da osmiophile Körperchen innerhalb der Mitochondrien in der unmittelbaren Nachbarschaft von Blutgefäßen und in einzelnen Gliazellen nur im Untersuchungs-material von operierten Tieren und nicht in normalen Kontrollen angetroffen werden, wird eine Kausalbeziehung mit der pathologischen Veränderung vermutet.

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Author notes

1. M. Hasan (DAAD-Fellow)
   Present address: Medical College Aligarh, India

Authors and Affiliations

1. Institut für Histologie und Neuroanatomie der Universität Göttingen, Kreuzbergring 36, 34 Göttingen, (Deutschland)
   P. Glees, M. Hasan (DAAD-Fellow) & K. Tischner

Authors

1. P. Glees
2. M. Hasan
3. K. Tischner

Additional information

This study was supported by a grant from the DFG Gl 28/IO.

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Glees, P., Hasan, M. & Tischner, K. The cytological distribution of ‘Osmiophilic Bodies’ in the normal and degenerating lateral geniculate nucleus of the monkey.Acta Neuropathol 8, 285–291 (1967). https://doi.org/10.1007/BF00688829

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• Received: 25 July 1966
• Issue date: September 1967
• DOI: https://doi.org/10.1007/BF00688829

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