Giardia lamblia: Identification of different strains from man (original) (raw)

Abstract

Four axenically cultured human_Giardia lamblia_ isolates from Jerusalem (KC-1, 2, 3 and 4) and one from Bethesda (WB) were compared. Three distinct groups were defined by agglutination response to rabbit anti-G. lamblia sera viz. WB; KC-3; and KC-1, 2 and 4. The same major groups were identified by isoenzyme analysis using thin-layer starch-gel electrophoresis, each group differing from the others in three or more of five enzymes studied. In addition, a single enzyme difference distinguished KC-2 from KC-1 and 4. These findings reveal significant heterogeneity in_G. lamblia_ isolates both from widely separated areas and within a single region. Immunoassays for diagnosis of giardiasis should take into account the differences between strains. Heterogeneity among_G. lamblia_ strains may explain the variable clinical manifestations, host response and treatment efficacy characteristic of human giardiasis.

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Authors and Affiliations

1. The Kuvin Centre for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School, POB 1172, 91010, Jerusalem, Israel
   S. H. Korman, S. M. Le Blancq, D. T. Spira, J. El On, R. M. Reifen & R. J. Deckelbaum
2. Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel
   S. H. Korman & R. J. Deckelbaum
3. Department of Gastroenterology, Hadassah University Hospital, Jerusalem, Israel
   R. J. Deckelbaum

Authors

1. S. H. Korman
2. S. M. Le Blancq
3. D. T. Spira
4. J. El On
5. R. M. Reifen
6. R. J. Deckelbaum

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Also called_G. intestinalis_ by other authors

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Korman, S.H., Le Blancq, S.M., Spira, D.T. et al. Giardia lamblia: Identification of different strains from man.Z. Parasitenkd. 72, 173–180 (1986). https://doi.org/10.1007/BF00931144

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• Accepted: 08 November 1985
• Issue date: March 1986
• DOI: https://doi.org/10.1007/BF00931144

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