The in vitro activity of ceftazidime against a multi-resistant serotype 12 Pseudomonas aeruginosa (original) (raw)

Summary

Highly resistant isolates of_Pseudomonas aeruginosa_ serotype 12 accounted for 42.2% of the pseudomonads isolated from patients in a 600-bed hospital over a period of 18 months.In vitro studies showed that this organism was resistant to tobramycin, gentamicin, apalcillin, piperacillin, azlocillin, ticarcillin, cefotaxime and cefsulodin. All serotype 12 isolates were completely sensitive to ceftazidime. Its geometric mean MIC was 3.4 mg/l. This new cephalosporin seems promising for the treatment of patients infected with pseudomonas, especially when a resistant strain such as serotype 12 is involved.

Zusammenfassung

Hochresistente_Pseudomonas aeruginosa-Isolate_, Serotyp 12, waren in einem Zeitraum von 18 Monaten mit 42,2% an den Pseudomonas-Isolierungen in einem 600-Betten-Hospital beteiligt._In-vitro_-Studien zeigten, daß diese Erreger gegen Tobramycin, Gentamicin, Apalcillin, Piperacillin, Azlocillin, Ticarcillin, Cefotaxim und Cefsulodin resistent waren. Alle Isolate vom Serotyp 12 waren auf Ceftazidim vollempfindlich; das geometrische Mittel der MHK-Werte betrug 3,4 mg/l. Dieses neue Cephalosporin erscheint damit erfolgversprechend für die Behandlung von Patienten mit Pseudomonas-Infektionen, insbesondere wenn ein resistenter Stamm wie Serotyp 12 beteiligt ist.

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Authors and Affiliations

  1. Laboratoire de Biologie Clinique, Hôpital de Jolimont, 7161 Haine-Saint-Paul, Jolimont, Belgium
    G. Ninane
  2. Glaxo Research Group Greenford, UB6 OHE, Middlesex, England, U.K.
    P. B. Harper

Authors

  1. G. Ninane
  2. P. B. Harper

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Ninane, G., Harper, P.B. The in vitro activity of ceftazidime against a multi-resistant serotype 12 Pseudomonas aeruginosa.Infection 11 (Suppl 1), S16–S19 (1983). https://doi.org/10.1007/BF01641099

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