Neuroleptic malignant syndrome and catatonia (original) (raw)

Summary

In a series of 1007 consecutively admitted patients, 3 cases of neuroleptic malignant syndrome (NMS) were identified (0.3%). All three patients were affected by mood disorders with congruent psychotic features, had shown catatonia just before the onset of NMS, and had been treated with low neuroleptic doses. All of them presented low serum iron levels. The relationship between NMS and catatonia and possible therapeutic decisions are discussed.

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References

• Addonizio G, Susman VL, Roth SD (1986) Symptoms of neuroleptic malignant syndrome in 82 consecutive inpatients. Am J Psychiatry 143:1587–1590
  Google Scholar
• Adityanjee, Singh S, Singh G (1988) Spectrum concept of neuroleptic malignant syndrome. Br J Psychiatry 153:107–111
  Google Scholar
• Adityanjee (1991) The myth of elevated serum creatine phosphokinase level and neuroleptic malignant syndrome. Br J Psychiatry 158:706–707
  Google Scholar
• Amore M, Montanari M (1992) La sindrome maligna da neurolettici e sindromi correlate. Minerva Psichiatr 33:259–283 (Summary in English)
  Google Scholar
• Barnes TRE, Halstead SM, Little PWA (1992) Relationship between iron status and chronic akathisia in an in-patient population with chronic schizophrenia. Br J Psychiatry 161:791–796
  Google Scholar
• Barton A, Bowie J, Ebmeier K (1990) Low plasma iron status and akathisia. J Neurol, Neurosurg Psychiatry 53:671–674
  Google Scholar
• Brown KW, Glen SE, White T (1987) Low-serum iron status and akathisia. Lancet I:1234–1236
  Google Scholar
• Caroff SN (1980) The neuroleptic malignant syndrome. J Clin Psychiatry 41:79–83
  Google Scholar
• Castillo E, Rubin RT, Holsboer-Trachsler E (1989) Clinical differentiation between lethal catatonia and neuroleptic malignant syndrome. Am J Psychiatry 146:324–328
  Google Scholar
• Davis JM, Janicak PG, Sakkas P, Gilmore C, Wang Z (1991) Electroconvulsive therapy in the treatment of the neuroleptic malignant syndrome. Convulsive Therapy 7(2):111–120
  Google Scholar
• Delay J, Deniker P (1986) Drug-induced extrapyramidal syndromes. In: Viken PJ, Bruyn GW (eds) Handbook of Clinical Neurology. North Holland, Amsterdam, pp. 248–266
  Google Scholar
• Gelenberg AJ, Bellinghausen B, Woicik JD, et al. (1988) A prospective survey of neuroleptic malignant syndrome in a short term psychiatric hospital. Am J Psychiatry 145:517–518
  Google Scholar
• Guze BH, Baxter LR (1985) Current concepts: neuroleptic malignant syndrome. N England J Med 313:163–166
  Google Scholar
• Kaufmann CA, Wyatt RJ (1987) Neuroleptic malignant syndrome. In: Meltzer HY (ed) Psychopharmacology. The Third Generation of Progress. Raven Press, New York. pp. 1421–1430
  Google Scholar
• Keck PE Jr, Pope HG Jr, McElroy SL (1987) Frequency and presentation of neuroleptic malignant syndrome: a prospective study. Am J Psychiatry 144:1344–1346
  Google Scholar
• Keck PE Jr, Harrison GP, Cohen BM, et al. (1989) Risk factors for neuroleptic malignant syndrome. Arch Gen Psychiatry 46: 914–918
  Google Scholar
• Kellam AMP (1987) The neuroleptic malignant syndrome, socalled. Br J Psychiatry 150:752–759
  Google Scholar
• Kellam AMP (1990) The (frequently) neuroleptic (potentially) malignant syndrome. Br J Psychiatry 157:169–173
  Google Scholar
• Levenson JM (1985) Neuroleptic malignant syndrome. Am J Psychiatry 142:1137–1145
  Google Scholar
• Mann SC, Caroff SN, Bleier HR, et al. (1986) Lethal catatonia. AM J Psychiatry 143:1374–1381
  Google Scholar
• Nemes ZC, Rotrosen J, Angrist B, et al. (1991) Biol Psychiatry 29: 411–413
  Google Scholar
• Neppe VM (1984) The neuroleptic malignant syndrome. S Afr Med J 65:523–525
  Google Scholar
• O'Loughlin V, Dickie AC, Ebmeier KP (1991) Serum iron transferrin in acute neuroleptic induced akathisia. J Neurol Neurosurg Psychiatry 54:363–364
  Google Scholar
• Pearlman CA (1986) Neuroleptic malignant syndrome: a review of the literature. J Clin Psychopharmacol 6:257–273
  Google Scholar
• Pope HG, Keck PE Jr, McElroy SLB (1986) Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital. Am J Psychiatry 143:1227–1233
  Google Scholar
• Rosenbush P, Stewart T (1989) A prospective analysis of 24 episodes of neuroleptic malignant syndrome. Am J Psychiatry 146:717–725
  Google Scholar
• Rosenberg MR Green M (1989) Neuroleptic malignant syndrome. Arch Intern Hed 149:1927–1931
  Google Scholar
• Rutledge JN, Hilal SK, Silver AJ, et al. (1987) Study of movement disorders and brain iron by MR. Am J Radiol 149:365–379
  Google Scholar
• Sachdev P, Longeragan C (1991) Acute drug-induced akathisia is not associated with low serum iron status. Psychopharmacology 103:138–139
  Google Scholar
• Scheftner WA, Shulman RB (1992) Treatment choice in neuroleptic malignant syndrome. Convulsive Therapy 8(4):267–279
  Google Scholar
• Shalev A, Munitz H (1986) The neuroleptic malignant syndrome: agent and host interaction. Acta Psychiatry Scand 73:337–347
  Google Scholar
• White DAC, Robins AH (1991) Catatonia: harbinger of the neuroleptic malignant syndrome. Br J Psychiatry 158:419–421
  Google Scholar

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Authors and Affiliations

1. Ospedale “Santo Spirito”, Dipartimento di salute mentale USL RM11, Servizio Psichiatrico di Diagnosi e Cura, via Prisciano 26, CAP 00136, Rome, Italy
   Michele Raja, Maria Concetta Altavista, Stefano Cavallari & Loredana Lubich

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1. Michele Raja
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2. Maria Concetta Altavista
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3. Stefano Cavallari
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4. Loredana Lubich
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Raja, M., Altavista, M.C., Cavallari, S. et al. Neuroleptic malignant syndrome and catatonia.Eur Arch Psychiatry Clin Nuerosci 243, 299–303 (1994). https://doi.org/10.1007/BF02195723

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• Received: 20 June 1993
• Issue Date: November 1994
• DOI: https://doi.org/10.1007/BF02195723

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