Anti-oxidant supplementation decreases TBA reactants in serum of elderly (original) (raw)

Abstract

An “anti-oxidant cocktail” consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents of a nursing home. Initially, the serum TBA reactant levels were higher (2.7±0.7 μmol/L) than those of an ad hoc control group of healthy younger adults (2.3±0.6 μmol/L),p<0.01. After three mo supplementation, the levels among the verum elderly had decreased to 2.2±0.6 μmol/L, and they remained at this lower level until the end of the study period, whereas the placebo group showed no change.

A significant inverse correlation (_r_=−0.428,p<0.01) existed between the concentrations of serum TBA reactants and whole blood selenium (B-Se), but only B-Se levels above 200 μg/L were associated with a decrease in serum lipid peroxides. Serum alpha-tocopherol concentration also correlated inversely with serum TBA reactants but this correlation (_r_=−0.273,p<0.76) was not as strong as that of B-Se.

Deficient vitamin B6 status, in biochemical terms, was observed in 25% of the elderly; a daily supplement of 2 mg B6 fully cured all cases of deficiency. The verum group improved slightly in several psychological tests, whereas subjects on placebo remained unchanged or deteriorated during the follow-up period. Clinical amelioration among the verum subjects was reported by the nurses; no toxic side effects were reported. In conclusion, the elderly benefited biochemically and clinically of dietary antioxidant supplements.

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References

  1. M. Tolonen, M. Halme, S. Sarna,Biol. Tr. Elem. Res. 7, 161–168 (1985).
    Article Google Scholar
  2. E. Beutler, K. D. Blume, J. C. Kaplan, G. W. Löhr, B. Ramot, and W. N. Valentine,Br. J. Haematol. 35, 331–340 (1977).
    PubMed CAS Google Scholar
  3. K. Yagi,Lipid Peroxides in Biology and Medicine, Academic Press, New York, 1982, pp. 223–242.
    Google Scholar
  4. J. Schrijver, B. W. C. van Veelen, W. H. P. Schreurs,Internat. J. Vit. Nutr. Res. 55, 337–349 (1985).
    CAS Google Scholar
  5. Working Group on Selenium. First annual report, MMM 1986: 23, Ministry of Agriculture and Forestry, Helsinki (in Finnish), 1986.
  6. D. Harman,J. Gerontol. 11, 298–300 (1956).
    PubMed CAS Google Scholar
  7. A. L. Tappel,Fed. Proc. 24, 73–78 (1965).
    PubMed CAS Google Scholar
  8. D. Harman,Freie Radikale. Vitamin E. Therapeutische Bedeutung. (eds. V. Böhlau, J. Reimann), Otto Hoffmanns Verlag, München 1986, pp. 19–34.
    Google Scholar
  9. W. A. Pryor, Proceedings of the XIII International Congress of Nutrition (Hrsg. T. G. Taylor, N. K. Jenkins), J. Libbey & Company Ltd., London, 1986, pp. 585–598.
    Google Scholar
  10. M. Uysal, H. Bulur, D. Sener,Int. J. Clin. Pharm. Theor. and Toxicol. 24, 474–476 (1986).
    CAS Google Scholar
  11. K. F. Gey,Bibliotheka Nutr. Dieta 37, 53–91 (1986).
    Google Scholar
  12. M. Mezez, A. Par, P. Nemeth,Int. Clin. Phar. Res. 4, 333–338 (1986).
    Google Scholar
  13. K. Takeda, Y. Shimada, M. Amano,Critical Care Medicine 12, 957–959 (1984).
    Article PubMed CAS Google Scholar
  14. K. F. Gey, G. B. Brubacher, H. B. Stähelin,Am. J. Clin. Nutr. 45, 1368–1377, 1987.
    PubMed CAS Google Scholar
  15. T. Westermarck, P. Santavouri,Med. Biol. 62, 148–151 (1984).
    PubMed CAS Google Scholar
  16. M. Tolonen, T. Westermarck, M. Halme,VitaMinSpur 1, 21–24 (1986).
    Google Scholar
  17. U. Vuonnala, T. Westermarck, P. Santavuori,Biolochemistry of Vitamin B 6, T. Korpela and P. Christen (eds.), Birkhäuser, Basel, Switzerland, 1987, pp. 411–416.
    Google Scholar
  18. Y. Yamamoto, M. H. Brodsky, J. C. Baker,Analytical Biochemistry 160, 7–13, 1987.
    Article PubMed CAS Google Scholar
  19. M. Wartanowicz, B. Panzenco-Kresowska, S. Ziemlanski, M. Kowalska, and G. Okolska,Ann. Nutr. Metab. 28, 186–191 (1984).
    PubMed CAS Google Scholar

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Authors and Affiliations

  1. Department of Public Health, University of Helsinki, Haartmaninkatu 3, SF-00290, Helsinki, Finland
    Matti Tolonen & Seppo Sarna
  2. Hartola Health Center, SF-19600, Hartola, Finland
    Markku Halme
  3. Lahti Health Center, SF-15100, Lahti, Finland
    Seppo E. J. Tuominen
  4. Helsinki Central Institute for Mentally Retarded, SF-02400, Kirkkonummi, Finland
    Tuomas Westermarck & Ulla-Riitta Nordberg
  5. Department of Applied Psychology, University of Helsinki, Fabianinkatu 28, SF-00100, Helsinki, Finand
    Mirja Keinonen
  6. CIVO-TNO Institute, Postbus, 360, NL-3700 AJ, Zeist, The Netherlands
    Jaap Schrijver

Authors

  1. Matti Tolonen
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  2. Seppo Sarna
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  3. Markku Halme
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  4. Seppo E. J. Tuominen
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  5. Tuomas Westermarck
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  6. Ulla-Riitta Nordberg
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  7. Mirja Keinonen
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  8. Jaap Schrijver
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Tolonen, M., Sarna, S., Halme, M. et al. Anti-oxidant supplementation decreases TBA reactants in serum of elderly.Biol Trace Elem Res 17, 221–228 (1988). https://doi.org/10.1007/BF02795458

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