The role of natural killer cells in tumor control—effectors and regulators of adaptive immunity (original) (raw)
- Ballas ZK, Turner JM, Turner DA, et al (1990) A patient with simultaneous absence of “classical” natural killer cells (CD3–, CD16+, and NKH1+) and expansion of CD3+, CD4–, CD8–, NKH1+ subset. J Allergy Clin Immunol 85:453
Google Scholar - Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245
Google Scholar - Bauer S, Groh V, Wu J, et al (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285:727
Google Scholar - Bennett IM, Zatsepina O, Zamai L, et al (1996) Definition of a natural killer NKR-P1A+/CD56–/CD16– functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12. J Exp Med, 184:1845
Google Scholar - Borrego F, Kabat J, Kim DK, et al (2002) Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells. Mol Immunol 38:637
Google Scholar - Brady J, Hayakawa Y, Smyth MJ, et al (2004) IL-21 induces the functional maturation of murine NK cells. J Immunol 172:2048
Google Scholar - Buentke E, Heffler LC, Wilson JL, et al (2002) Natural killer and dendritic cell contact in lesional atopic dermatitis skin—Malassezia-influenced cell interaction. J Invest Dermatol 119:850
Google Scholar - Campbell JJ, Qin S, Unutmaz D, et al (2001) Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol 166:6477
Google Scholar - Cerwenka A, Baron JL, Lanier LL (2001) Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc Natl Acad Sci USA 98:11521
Google Scholar - Cerwenka A, Lanier LL (2001) Ligands for natural killer cell receptors: redundancy or specificity. Immunol Rev 181:158
Google Scholar - Cerwenka A, Lanier LL (2001) Natural killer cells, viruses and cancer. Nat Rev Immunol 1:41
Google Scholar - Chalifour A, Jeannin P, Gauchat JF, et al (2004) Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production. Blood 104:1778
Google Scholar - Colucci F, Caligiuri MA, Di Santo JP (2003) What does it take to make a natural killer? Nat Rev Immunol 3:413
Google Scholar - Cooper MA, Fehniger TA, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22:633
Google Scholar - Cooper MA, Fehniger TA, Fuchs A, et al (2004) NK cell and DC interactions. Trends Immunol 25:47
Google Scholar - Cretney E, Takeda K, Yagita H, et al (2002) Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 168:1356
Google Scholar - Cui Z, Willingham MC, Hicks AM, et al (2003) Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci USA 100:6682
Google Scholar - Davis JE, Smyth MJ, Trapani JA (2001) Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity. Eur J Immunol 31:39
Google Scholar - Della Chiesa M, Vitale M, Carlomagno S, et al (2003) The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors. Eur J Immunol 33:1657
Google Scholar - Diefenbach A, Jensen ER, Jamieson AM, et al (2001) Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413:165
Google Scholar - Diefenbach A, Tomasello E, Lucas M, et al (2002) Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol 3:1142
Google Scholar - Dokun AO, Kim S, Smith HR, et al (2001) Specific and nonspecific NK cell activation during virus infection. Nat Immunol 2:951
Google Scholar - Edwards AD, Diebold SS, Slack EM, et al (2003) Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol 33:827
Google Scholar - Ferlazzo G, Morandi B, D’Agostino A, et al (2003) The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells. Eur J Immunol 33:306
Google Scholar - Ferlazzo G, Munz C (2004) NK cell compartments and their activation by dendritic cells. J Immunol 172:1333
Google Scholar - Ferlazzo G, Semino C, Melioli G (2001) HLA class I molecule expression is up-regulated during maturation of dendritic cells, protecting them from natural killer cell-mediated lysis. Immunol Lett 76:37
Google Scholar - Ferlazzo G, Thomas D, Lin SL, et al (2004) The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol 172:1455
Google Scholar - Ferlazzo G, Tsang ML, Moretta L, et al (2002) Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med 195:343
Google Scholar - Fernandez NC, Lozier A, Flament C, et al (1999) Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5:405
Google Scholar - Gallucci S, Lolkema M, Matzinger P (1999) Natural adjuvants: endogenous activators of dendritic cells. Nat Med 5:1249
Google Scholar - Gao Y, Yang W, Pan M, et al (2003) Gamma delta T cells provide an early source of interferon gamma in tumor immunity. J Exp Med 198:433
Google Scholar - Garni-Wagner BA, Purohit A, Mathew PA, et al (1993) A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J Immunol 151:60
Google Scholar - Geldhof AB, Raes G, Bakkus M, et al (1995) Expression of B7–1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity. Cancer Res 55:2730
Google Scholar - Gerosa F, Baldani-Guerra B, Nisii C, et al (2002) Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med 195:327
Google Scholar - Granucci F, Vizzardelli C, Pavelka N, et al (2001) Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol 2:882
Google Scholar - Granucci F, Zanoni I, Pavelka N, et al (2004) A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J Exp Med 200:287
Google Scholar - Griffith TS, Chin WA, Jackson GC, et al (1998) Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J Immunol 161:2833
Google Scholar - Haliotis T, Ball JK, Dexter D, et al (1985) Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice. Int J Cancer 35:505
Google Scholar - Hashimoto W, Tanaka F, Robbins PD, et al (2003) Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18. Int J Cancer 103:508
Google Scholar - Hayakawa Y, Kelly JM, Westwood JA, et al (2002) Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin. J Immunol 169:5377
Google Scholar - Hayakawa Y, Screpanti V, Yagita H, et al (2004) NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy. J Immunol 172:123
Google Scholar - Hayakawa Y, Takeda K, Yagita H, et al (2002) IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide. Blood 100:1728
Google Scholar - Houchins JP, Yabe T, McSherry C, et al (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med 173:1017
Google Scholar - Ikeda H, Old LJ, Schreiber RD (2002) The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev 13:95
Google Scholar - Irmler M, Thome M, Hahne M, et al (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388:190
Google Scholar - Kadowaki N, Ho S, Antonenko S, et al (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 194:863
Google Scholar - Karre K, Ljunggren HG, Piontek G, et al (1986) Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319:675
Google Scholar - Kasaian MT, Whitters MJ, Carter LL, et al (2002) IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16:559
Google Scholar - Kelly JM, Darcy PK, Markby JL, et al (2002) Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection. Nat Immunol 3:83
Google Scholar - Kelly JM, Takeda K, Darcy PK, et al (2002) A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo. J Immunol 168:4472
Google Scholar - Kennedy MK, Glaccum M, Brown SN, et al (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191:771
Google Scholar - Kiessling R, Petranyi G, Klein G, et al (1975) Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non-immunized semi-syngeneic mice against a mouse lymphoma line. Int J Cancer 15:933
Google Scholar - Kim S, Iizuka K, Kang HS, et al (2002) In vivo developmental stages in murine natural killer cell maturation. Nat Immunol 3:523
Google Scholar - Lanier LL (1998) NK cell receptors. Annu Rev Immunol 16:359
Google Scholar - Lanier LL, Le AM, Civin CI, et al (1986) The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol 136:4480
Google Scholar - Lian RH, Kumar V (2002) Murine natural killer cell progenitors and their requirements for development. Semin Immunol 14:453
Google Scholar - Liao NS, Bix M, Zijlstra M, et al (1991) MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science 253:199
Google Scholar - Ljunggren HG, Karre K (1985) Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism. J Exp Med 162:1745
Google Scholar - Loza MJ, Perussia B (2001) Final steps of natural killer cell maturation: a model for type 1-type 2 differentiation? Nat Immunol 2:917
Google Scholar - Martin-Fontecha A, Thomsen LL, Brett S et al. (2004) Induced recruitment of NK cells to lymph nodes provides IFN-γ for Th1 priming. Nat Immunol 5:1260
Google Scholar - McQueen KL, Parham P (2002) Variable receptors controlling activation and inhibition of NK cells. Curr Opin Immunol 14:615
Google Scholar - Medzhitov R, Janeway CA Jr (1998) Innate immune recognition and control of adaptive immune responses. Semin Immunol 10:351
Google Scholar - Mellman I, Steinman RM (2001) Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255
Google Scholar - Mocikat R, Braumuller H, Gumy A, et al (2003) Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses. Immunity 19:561
Google Scholar - Moroz A, Eppolito C, Li Q, et al (2004) IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J Immunol 173:900
Google Scholar - Moser M (2003) Dendritic cells in immunity and tolerance-do they display opposite functions? Immunity 19:5
- O’Hanlon LH (2004) Natural born killers: NK cells drafted into the cancer fight. J Natl Cancer Inst 96:651
Google Scholar - Ogasawara K, Yoshinaga SK, Lanier LL (2002) Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells. J Immunol 169: 3676
Google Scholar - Pawelec G, Da Silva P, Max H, et al (1995) Relative roles of natural killer- and T cell-mediated anti-leukemia effects in chronic myelogenous leukemia patients treated with interferon-alpha. Leuk Lymphoma 18:471
Google Scholar - Peritt D, Robertson S, Gri G, et al (1998) Differentiation of human NK cells into NK1 and NK2 subsets. J Immunol 161:5821
Google Scholar - Piccioli D, Sbrana S, Melandri E, et al (2002) Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J Exp Med 195:335
Google Scholar - Reis e Sousa C, Diebold SD, Edwards AD, et al (2003) Regulation of dendritic cell function by microbial stimuli. Pathol Biol (Paris) 51:67
- Robertson MJ (2002) Role of chemokines in the biology of natural killer cells. J Leukoc Biol 71:173
Google Scholar - Rosenberg SA (2000) Interleukin-2 and the development of immunotherapy for the treatment of patients with cancer. Cancer J Sci Am 6 Suppl 1: S2
- Roth C, Carlyle JR, Takizawa H, et al (2000) Clonal acquisition of inhibitory Ly49 receptors on developing NK cells is successively restricted and regulated by stromal class I MHC. Immunity 13:143
Google Scholar - Ruggeri L, Capanni M, Urbani E, et al (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295: 2097
- Sauter B, Albert ML, Francisco L, et al (2000) Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191:423
Google Scholar - Screpanti V, Wallin RP, Ljunggren HG, et al (2001) A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells. J Immunol 167:2068
Google Scholar - Seya T, Akazawa T, Uehori J, et al (2003) Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer. Anticancer Res 23:4369
Google Scholar - Shortman K, Liu YJ (2002) Mouse and human dendritic cell subtypes. Nat Rev Immunol 2:151
Google Scholar - Silla LM, Whiteside TL, Ball ED (1995) The role of natural killer cells in the treatment of chronic myeloid leukemia. J Hematother 4:269
Google Scholar - Sivakumar PV, Foster DC, Clegg CH (2004) Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. Immunology 112:177
Google Scholar - Sivori S, Falco M, Della Chiesa M, et al (2004) CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci USA 101:10116
Google Scholar - Smyth MJ, Cretney E, Takeda K, et al (2001) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J Exp Med 193:661
Google Scholar - Smyth MJ, Crowe NY, Godfrey DI (2001) NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int Immunol 13:459
Google Scholar - Smyth MJ, Hayakawa Y, Takeda K, et al (2002) New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2:850
Google Scholar - Smyth MJ, Street SE, Trapani JA (2003) Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol 171:515
Google Scholar - Smyth MJ, Takeda K, Hayakawa Y, et al (2003) Nature’s TRAIL—on a path to cancer immunotherapy. Immunity 18:1
Google Scholar - Smyth MJ, Taniguchi M, Street SE (2000) The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J Immunol 165:2665
Google Scholar - Smyth MJ, Thia KY, Cretney E, et al (1999) Perforin is a major contributor to NK cell control of tumor metastasis. J Immunol 162:6658
Google Scholar - Smyth MJ, Thia KY, Street SE, et al (2000) Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med 191:661
Google Scholar - Smyth MJ, Thia KY, Street SE, et al (2000) Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma. J Exp Med 192:755
Google Scholar - Smyth MJ, Trapani JA (1995) Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today 16:202
Google Scholar - Stepp SE, Dufourcq-Lagelouse R, Le Deist F, et al (1999) Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 286:1957
Google Scholar - Street SE, Cretney E, Smyth MJ (2001) Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97:192
Google Scholar - Street SE, Hayakawa Y, Zhan Y, et al (2004) Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and γδ T cells. J Exp Med 199:879
Google Scholar - Takeda K, Hayakawa Y, Smyth MJ, et al (2001) Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 7:94
Google Scholar - Takeda K, Smyth MJ, Cretney E, et al (2002) Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med 195:161
Google Scholar - Takei F, McQueen KL, Maeda M, et al (2001) Ly49 and CD94/NKG2: developmentally regulated expression and evolution. Immunol Rev 181:90
Google Scholar - Trapani JA, Smyth MJ (2002) Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2:735
Google Scholar - Trinchieri G (1998) Immunobiology of interleukin-12. Immunol Res 17:269
- Van den Broek MF, Kagi D, Zinkernagel RM, et al (1995) Perforin dependence of natural killer cell-mediated tumor control in vivo. Eur J Immunol 25:3514
Google Scholar - Waldmann TA, Tagaya Y (1999) The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 17:19
Google Scholar - Whiteside TL, Herberman RB (1995) The role of natural killer cells in immune surveillance of cancer. Curr Opin Immunol 7:704
Google Scholar - Whiteside TL, Vujanovic NL and Herberman RB (1998) Natural killer cells and tumor therapy. Curr Top Microbiol Immunol 230:221
Google Scholar - Williams NS, Moore TA, Schatzle JD, et al (1997) Generation of lytic natural killer 1.1+, Ly-49- cells from multipotential murine bone marrow progenitors in a stroma-free culture: definition of cytokine requirements and developmental intermediates. J Exp Med 186:1609
Google Scholar - Wilson JL, Heffler LC, Charo J, et al (1999) Targeting of human dendritic cells by autologous NK cells. J Immunol 163:6365
Google Scholar - Wilson MJ, Torkar M, Haude A, et al (2000) Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci USA 97:4778
Google Scholar - Wooldridge JE, Weiner GJ (2003) CpG DNA and cancer immunotherapy: orchestrating the antitumor immune response. Curr Opin Oncol 15:440
Google Scholar - Wu J, Lanier LL (2003) Natural killer cells and cancer. Adv Cancer Res 90:127
Google Scholar - Yasumura S, Lin WC, Hirabayashi H, et al (1994) Immunotherapy of liver metastases of human gastric carcinoma with interleukin 2-activated natural killer cells. Cancer Res 54:3808
Google Scholar - Yokoyama WM, Daniels BF, Seaman WE, et al (1995) A family of murine NK cell receptors specific for target cell MHC class I molecules. Semin Immunol 7:89
Google Scholar - Yokoyama WM, Plougastel BF (2003) Immune functions encoded by the natural killer gene complex. Nat Rev Immunol 3:304
Google Scholar - Yuan D, Koh CY, Wilder JA (1994) Interactions between B lymphocytes and NK cells. FASEB J, 8:1012
Google Scholar - Zitvogel L (2002) Dendritic and natural killer cells cooperate in the control/switch of innate immunity. J Exp Med 195:F9
Google Scholar