Isolation and phylogenetic characterization of bat astroviruses in southern China (original) (raw)
Abstract
Astroviruses are associated with acute gastroenteritis of human and many animal species. Recently, two studies have reported that novel astroviruses were found in bats. In order to extensively understand the genetic and phylogenetic characterization of bat astroviruses, we tested fecal samples of nine bat species that were collected at four natural habitats in three areas of southern China. The geographic distributions of the bats involved differed from previous reports. Three out of nine species of bats were observed to harbor astroviruses. These included Miniopterus schreibersii, Scotophilus kuhlii, and Rousettus leschenaultia. Phylogenetic analysis based on amino acid sequences of partial ORFs of astroviruses revealed that the bat astroviruses are not only divergent from previously described human and other animal astroviruses but also show remarkable diversity among themselves. However, five bat astroviruses were phylogenetically related to mink astrovirus, ovine astrovirus, and the recently discovered human astroviruses VA1, VA2, and VA3. The results indicate that astroviruses may have adapted to the Chiroptera, and bats may transmit astroviruses to humans and other animals, or vice versa.
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Acknowledgments
We sincerely thank Dr. Poon for helpful suggestions and discussions. This work was supported by National Natural Science Foundation of China (Grant No. 30571610), National Natural Science Foundation of Guangdong Province (Grant No. 8151051501000056, 8151009101000005), and Guangdong Province “211 Project”.
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Authors and Affiliations
- Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong, China
Jianpeng Xiao, Jiandong Li, Guifang Hu, Yixiong Chen, Zhiyong Chen, Yuxue Liao, Jie Zhou, Xuemei Ke, Lizhen Ma, Shan Liu, Junhua Zhou, Yingchun Dai, Hongbiao Chen, Shouyi Yu & Qing Chen - Key Laboratory of Prevention and Control of Emerging Infectious Diseases of Guangdong Higher Education Institutes, Southern Medical University, Guangzhou, 510515, China
Jianpeng Xiao, Lizhen Ma, Shan Liu & Qing Chen - College of Life Science, Hainan Normal University, Haikou, 571158, China
Zhong Chen - College of Life Science, Guangzhou University, Guangzhou, 510006, China
Yi Wu
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- Jianpeng Xiao
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Xiao, J., Li, J., Hu, G. et al. Isolation and phylogenetic characterization of bat astroviruses in southern China.Arch Virol 156, 1415–1423 (2011). https://doi.org/10.1007/s00705-011-1011-2
- Received: 18 January 2011
- Accepted: 25 April 2011
- Published: 14 May 2011
- Issue Date: August 2011
- DOI: https://doi.org/10.1007/s00705-011-1011-2