Incidence and risk factors associated with urinary tract infection in diabetic patients with and without asymptomatic bacteriuria (original) (raw)

Abstract

In order to compare the incidence of symptomatic urinary tract infection (UTI) in diabetic patients with and without asymptomatic bacteriuria (ASB), and to identify other risk factors for these infections, 289 females and 168 males were studied over a 12-month period. Symptomatic UTI occurred in 69.2% of patients with ASB (67.6% female and 76.5% male) versus 9.8% without ASB (14.9% female and 2.6% male). ASB and urinary incontinence were associated with symptomatic UTI in both women and men. Other risk factors included previous antimicrobial treatment and macrovascular complications in women and obesity and prostatic syndrome in men. The presence of ASB was found to be the major risk factor for developing symptomatic urinary tract infection. Further prospective randomized clinical trials of diabetic patients with risk factors for UTI who are receiving or not receiving treatment may be considered.

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References

  1. Abrutyn E, Mossey J, Berlin JA et al (1994) Does asymptomatic bacteriuria predict mortality and does antimicrobial treatment reduce mortality in elderly ambulatory women? Ann Intern Med 120:827–833
    PubMed CAS Google Scholar
  2. Patterson JE, Andriole VT (1995) Bacterial urinary tract infections in diabetes. Infect Dis Clin North Am 9:25–51
    PubMed CAS Google Scholar
  3. Zhanel GG, Nicolle LE, Harding GK, Manitoba Diabetic Urinary Infection Study Group (1995) Prevalence of asymptomatic bacteriuria and associated host factors in women with diabetes mellitus. Clin Infect Dis 21:316–322
    PubMed CAS Google Scholar
  4. Geerlings SE, Stolk RP, Camps MJL, Netten PM, Collet JT, Hoepelman AI, (2000) Risk factors for symptomatic urinary tract infection in women with diabetes. Diabetes Care 23:1737–1741
    Article PubMed CAS Google Scholar
  5. Nicolle LE (2000) Asymptomatic bacteriuria in diabetic women. Diabetes Care 23:722–723
    Article PubMed CAS Google Scholar
  6. Harding GKM, Zhanel GG, Nicolle LE (2002) Antimicrobial treatment in diabetic women with asymptomatic bacteriuria. N Engl J Med 347:1576–1583
    Article PubMed Google Scholar
  7. American Diabetes Association (2001) Clinical practice. Recommendations 2001. Diabetes Care 24(Suppl 1):33–44
    Google Scholar
  8. European Diabetes Policy Group 1999 (1999) A desktop guide for the management of type 2 diabetes mellitus. Diabet Med 16:716–730
    Article Google Scholar
  9. Keane EM, Boyko E, Reller LB, Hamman RF (1988) Prevalence of asymptomatic bacteriuria in subjects with NIDDM in San Luis Valley Colorado. Diabetes Care 11:708–712
    Article PubMed CAS Google Scholar
  10. Bonadio M, Boldrini E, Forotti G, Matteucci E, Vigna A, Mori S, Giampietro O (2004) Asymptomatic bacteriuria in women with diabetes: influence of metabolic control. Clin Infect Dis 38:e41–e45
    Article PubMed Google Scholar
  11. Geerlings SE, Stolk RP, Camps MJL, Netten PM, Hoekstra JBL, Bouter KP, Bravenboer B, Collet JT, Jansz AR, Hoepelman AI (2000) Asymptomatic bacteriuria may be considered a complication in women with diabetes. Diabetes Care 23:744–749
    Article PubMed CAS Google Scholar
  12. Nicolle LE (1999) Urinary infections in the ederly: symptomatic or asymptomatic. Int J Antimicrob Agents 11:265–268
    Article PubMed CAS Google Scholar
  13. Geerlings SE, Stolk RP, Camps MJL, Netten PM, Collet JT, Schneeberger PM, Hoepelman AIM (2001) Consequences of asymptomatic bacteriuria in women with diabetes mellitus. Arch Intern Med 161:1421–1427
    Article PubMed CAS Google Scholar
  14. Boyko E, Fihn S, Scholes D, Chen C, Norman E, Yarbro P (2002) Diabetes mellitus and the risk of acute urinary tract infection among post-menopausal women. Diabetes Care 25:1778–1783
    Article PubMed Google Scholar
  15. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM (2005) Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 40:643–654
    Article PubMed Google Scholar

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Acknowledgements

Mr. Damian St John Tompson, Mr. Pablo Ortega Gil and Ms. Eva Sáez Sanchís are acknowledged for their assistance in reviewing the manuscript.

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Authors and Affiliations

  1. Department of Clinical Medicine, Miguel Hernández University, Campus de San Juan, San Juan, Alicante, 03550, Spain
    M. C. Ribera, R. Pascual, D. Orozco, C. Pérez Barba & V. Gil
  2. Department of Internal Medicine, General Hospital of Elda, Carretera Elda-Sax por la Torreta s/n. Elda, 03600, Alicante, Spain
    M. C. Ribera, R. Pascual, D. Orozco, C. Pérez Barba, V. Pedrera & V. Gil

Authors

  1. M. C. Ribera
  2. R. Pascual
  3. D. Orozco
  4. C. Pérez Barba
  5. V. Pedrera
  6. V. Gil

Corresponding author

Correspondence toR. Pascual.

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Ribera, M.C., Pascual, R., Orozco, D. et al. Incidence and risk factors associated with urinary tract infection in diabetic patients with and without asymptomatic bacteriuria.Eur J Clin Microbiol Infect Dis 25, 389–393 (2006). https://doi.org/10.1007/s10096-006-0148-5

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