Therapeutic Effect of Lactobacillus acidophilus-SDC 2012, 2013 in Patients with Irritable Bowel Syndrome (original) (raw)
Abstract
Probiotic bacteria exhibit a variety of properties, which are unique to a particular strain. _Lactobacillus acidophilus_-SDC 2012, 2013 are new strains isolated from Korean infants’ feces. The potential utility of _Lactobacillus acidophilus_-SDC 2012, 2013 in irritable bowel syndrome (IBS) was studied. Forty IBS patients were randomized into a placebo (n = 20) and probiotics group (n = 20). Four weeks of treatment with _L. acidophilus-_SDC 2012, 2013 was associated with a reduced score for abdominal pain or discomfort compared to the baseline (P = 0.011). The percent reduction in abdominal pain or discomfort exceeded the placebo scores by more than 20% (23.8 and 0.2% for probiotics and placebo, respectively, P = 0.003). There was a significant difference in the proportion of responders between the probiotics and placebo groups (P = 0.011). There was no drop out or adverse events for either group during the study period. _Lactobacillus acidophilus_-SDC 2012, 2013 appeared to have a beneficial effect in patients with IBS. Further studies are warranted.
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References
- Schrezenmeir J, de Vrese M (2001) Probiotics, prebiotics, and synbiotics–approaching a definition. Am J Clin Nutr 73:361S–364S
PubMed CAS Google Scholar - Floch MH, Madsen KK, Jenkins DJ, Guandalini S, Katz JA, Onderdonk A, Walker WA, Fedorak RN, Camilleri M (2006) Recommendations for probiotic use. J Clin Gastroenterol 40:275–278
Article PubMed Google Scholar - Quigley EM, Flourie B (2007) Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. Neurogastroenterol Motil 19:166–172
Article PubMed CAS Google Scholar - Nobaek S, Johansson ML, Molin G, Ahrne S, Jeppsson B (2000) Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol 95:1231–1238
Article PubMed CAS Google Scholar - Niedzielin K, Kordecki H, Birkenfeld B (2001) A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 13:1143–1147
Article PubMed CAS Google Scholar - Kim HJ, Camilleri M, McKinzie S, Lempke MB, Burton DD, Thomforde GM, Zinsmeister AR (2003) A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 17:895–904
Article PubMed CAS Google Scholar - O’Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, O’Sullivan GC, Kiely B, Collins JK, Shanahan F, Quigley EM (2005) Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 128:541–551
Article PubMed Google Scholar - Rhee PL (2006) Definition and epidemiology of irritable bowel syndrome. Korean J Gastroenterol 47:94–100
PubMed Google Scholar - Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC (2006) Functional bowel disorders. Gastroenterology 130:1480–1491
Article PubMed Google Scholar - Heaton KW, Radvan J, Cripps H, Mountford RA, Braddon FE, Hughes AO (1992) Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 33:818–824
Article PubMed CAS Google Scholar - Irvine EJ, Whitehead WE, Chey WD, Matsueda K, Shaw M, Talley NJ, Veldhuyzen van Zanten SJ (2006) Design of treatment trials for functional gastrointestinal disorders. Gastroenterology 130:1538–1551
Article PubMed Google Scholar - Wilson A, Longstreth GF, Knight K, Wong J, Wade S, Chiou CF, Barghout V, Frech F, Ofman JJ (2004) Quality of life in managed care patients with irritable bowel syndrome. Manag Care Interface 17:24–28, 34
Google Scholar - Longstreth GF, Wilson A, Knight K, Wong J, Chiou CF, Barghout V, Frech F, Ofman JJ (2003) Irritable bowel syndrome, health care use, and costs: a U.S. managed care perspective. Am J Gastroenterol 98:600–607
Article PubMed Google Scholar - Camilleri M (2006) Probiotics and irritable bowel syndrome: rationale, putative mechanisms, and evidence of clinical efficacy. J Clin Gastroenterol 40:264–269
Article PubMed Google Scholar - Ringel-Kulka T, Ringel Y (2007) Probiotics in irritable bowel syndrome: has the time arrived? Gastroenterology 132:813–816; discussion 816
Article PubMed Google Scholar - Riordan SM, Kim R (2006) Bacterial overgrowth as a cause of irritable bowel syndrome. Curr Opin Gastroenterol 22:669–673
Article PubMed Google Scholar - Sharara AI, Aoun E, Abdul-Baki H, Mounzer R, Sidani S, Elhajj I (2006) A randomized double-blind placebo-controlled trial of rifaximin in patients with abdominal bloating and flatulence. Am J Gastroenterol 101:326–333
Article PubMed CAS Google Scholar - Kajander K, Hatakka K, Poussa T, Farkkila M, Korpela R (2005) A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Aliment Pharmacol Ther 22:387–394
Article PubMed CAS Google Scholar - Camilleri M (2006) Is there a role for probiotics in irritable bowel syndrome? Dig Liver Dis 38(Suppl 2):S266–S269
Article PubMed Google Scholar
Acknowledgement
Financial support: The authors were supported, in part, by grants from the Seoul Research and Business Development Program (No. 10582).
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Authors and Affiliations
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Dong Hyun Sinn, Hoi Jin Kim, Jun Haeng Lee, Hee Jung Son, Dong Kyung Chang, Young-Ho Kim, Jae J. Kim, Jong Chul Rhee & Poong-Lyul Rhee - Healthcare System, Gangnam Center, Seoul National University Hospital, Seoul, Korea
Ji Hyun Song - Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Korea
Poong-Lyul Rhee
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Correspondence toPoong-Lyul Rhee.
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Sinn, D.H., Song, J.H., Kim, H.J. et al. Therapeutic Effect of _Lactobacillus acidophilus_-SDC 2012, 2013 in Patients with Irritable Bowel Syndrome.Dig Dis Sci 53, 2714–2718 (2008). https://doi.org/10.1007/s10620-007-0196-4
- Received: 01 October 2007
- Accepted: 21 December 2007
- Published: 15 February 2008
- Issue Date: October 2008
- DOI: https://doi.org/10.1007/s10620-007-0196-4