Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial (original) (raw)

Abstract

Mild Cognitive Impairment (MCI) is considered a transitional stage in the pathogenesis of Alzheimer’s disease; however, not all MCI patients progress to clinically defined AD or decline at identical rates. Hippocampal atrophy, as measured by Magnetic Resonance Imaging (MRI), may be a marker for hippocampal pathology in patients with MCI and predict a more rapid deterioration to clinical AD. In this study, we used MRI data from an ongoing MCI clinical trial to determine whether MRI hippocampal volume at baseline was associated with cognitive and functional performance in MCI subjects and whether it predicted those individuals who were more likely to develop AD. We performed correlational analyses between the MRI hippocampal volumes at study entry and the subjects’ concurrent performance on neuropsychological measures and clinical ratings. Larger hippocampal volume was associated with better performance on tests of memory, general cognition, and overall clinical ratings. Further analyses suggested that a smaller baseline hippocampal volume may be associated with a higher risk of developing clinical AD. As the trial is still ongoing, these results require confirmation once the trial is completed. In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD.

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Authors and Affiliations

1. Department of Neurosciences, University of California, San Diego, La Jolla, CA
   Michael Grundman, Hyun T. Kim, Arlan Schultz, Ronald G. Thomas & Leon J. Thal
2. Departments of Diagnostic Radiology, Neurology, Mayo Clinic and Foundation, Rochester, MN
   Drahomira Sencakova, Clifford R. Jack & Ronald C. Petersen
3. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX
   Myron F. Weiner
4. Department of Neurology, University of California, Davis, CA
   Charles DeCarli
5. Department of Neurology, University of Pittsburgh, Pittsburgh, PA
   Steven T. DeKosky
6. Department of Psychiatry, Yale University School of Medicine, New Haven, CT
   Christopher van Dyck

Authors

1. Michael Grundman
2. Drahomira Sencakova
3. Clifford R. Jack
4. Ronald C. Petersen
5. Hyun T. Kim
6. Arlan Schultz
7. Myron F. Weiner
8. Charles DeCarli
9. Steven T. DeKosky
10. Christopher van Dyck
11. Ronald G. Thomas
12. Leon J. Thal

Consortia

the Alzheimer’s Disease Cooperative Study

Corresponding author

Correspondence toMichael Grundman.

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Grundman, M., Sencakova, D., Jack, C.R. et al. Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial.J Mol Neurosci 19, 23–27 (2002). https://doi.org/10.1007/s12031-002-0006-6

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• Received: 04 August 2001
• Accepted: 16 August 2001
• Issue date: August 2002
• DOI: https://doi.org/10.1007/s12031-002-0006-6

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