Schizophrenic syndromes, cognitive performance and neurological dysfunction | Psychological Medicine | Cambridge Core (original) (raw)

Synopsis

In a sample of chronic schizophrenic patients, a group of symptoms which included poverty of speech and lack of spontaneous movement was found to be associated with poor performance in tests of conceptual thinking, object naming and long-term memory, and also with cortical neurological signs. A second group of symptoms which included formal thought disorder and inappropriate affect was associated with poor performance in tests of concentration, immediate recall and word learning, and with cortical neurological signs. The findings suggest that these two syndromes are associated with dysfunction at two different sites within the frontal lobes. A third group of symptoms, comprising various delusions and hallucinations, was associated with poor figure-ground perception, and might reflect temporal lobe dysfunction.

References

American Psychiatric Association (1980). Diagnostic and Statistical Manual for Psychiatric Disorders (third edn). APA: Washington D.C.Google Scholar

Andreasen, N. C. (1983). Comprehensive Assessment of Symptoms and History. University of Iowa College of Medicine: Iowa.Google Scholar

Andreasen, N. C. & Olsen, S. (1982). Negative v. positive schizophrenia. Archives of General Psychiatry 39, 789–794.CrossRefGoogle ScholarPubMed

Ayers, A. J. (1966). Southern California Figure-Ground Visual Perception Test. Western Psychological Services: Los Angeles.Google Scholar

Bannon, M. J. & Roth, R. H. (1983). Pharmacology of mesocortical dopamine neurons. Pharmacological Reviews 35, 53–68.Google ScholarPubMed

Blumer, D. & Benson, D. F. (1975). Personality changes with frontal lobe lesions. In Psychiatric Aspects of Neurological Disease (ed. Blumer, D and Benson, D F), pp. 151–170. Grune & Stratton: New York.Google Scholar

Clark, C. M., Kessler, R., Buchsbaum, M. S., Margolin, R. A. & Holcomb, H. H. (1984). Correlational methods for determining regional coupling of cerebral glucose metabolism: a pilot study. Biological Psychiatry 19, 663–678.Google ScholarPubMed

Crow, T. J.. (1980). Molecular pathology of schizophrenia: more than one disease process? British Medical Journal 280, 66–68.CrossRefGoogle ScholarPubMed

Crow, T. J., Johnstone, E. C. & Owen, F. (1979). Research on schizophrenia. In Recent Advances in Clinical Psychiatry Number 3 (ed. Granville-Grossman, K.), pp. 1–36Churchill Livingstone: Edinburgh.Google Scholar

Davis, J. M. (1976). Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry 33, 858–861.CrossRefGoogle ScholarPubMed

Davison, K. & Bagley, C. R. (1969). Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. In Current Problems in Neuropsychiatry: Schizophrenia, Epilepsy and the Temporal Lobe (ed. Herrington, R. N.), pp. 113–189. Headley: Ashford, Kent.Google Scholar

Dunn, L. M. (1959). Peabody Picture Vocabulary Test. American Guidance Service Inc.: Minneapolis.Google Scholar

Goldstein, G. (1978), Cognitive and perceptual differences between schizophrenics and organics. Schizophrenia Bulletin 4, 160–185.CrossRefGoogle ScholarPubMed

Goldstein, G. & Halperin, K. M. (1977). Neuropsychological differences among sub-types of schizophrenia. Journal of Abnormal Psychology 86, 34–40.CrossRefGoogle Scholar

Kolb, B. & Wishaw, I. Q. (1980). Fundamentals of Human Neuropsychology. Freeman: San Francisco.Google Scholar

Lezak, M. D. (1976). Neuropsychological Assessment. Oxford University Press: New York.Google Scholar

Liddle, P. F. (1986). The symptoms of chronic schizophrenia: a re-examination of the positive–negative dichotomy. British Journal of Psychiatry (in the press).Google Scholar

Magaro, P. A. (1981). The paranoid and the schizophrenic: the case for a distinct cognitive style. Schizophrenia Bulletin 7, 632–661.CrossRefGoogle ScholarPubMed

Newcombe, F. & Marshall, J. (1967). Immediate recall of sentences. Neuropsychologia 5, 329–334.CrossRefGoogle Scholar

Newcombe, F., Oldfield, R. L., Ratcliff, G. G. & Wingfield, A. (1971). Recognition and naming of object-drawings by men with focal brain wounds. Journal of Neurology, Neurosurgery and Psychiatry 34, 329–340.CrossRefGoogle ScholarPubMed

Payne, R. W. & Hewlett, J. G. H. (1960). Thought disorder in psychotic patients. In Experiments in Personality Vol. 2 (ed. Eysenck, H. J.), pp. 3–104. Routledge and Kegan Paul: London.Google Scholar

Pycock, C. J., Kerwin, R. W. & Carter, C. J. (1980). Effects of lesion of cortical dopamine terminals on sub-cortical dopamine receptors in rats. Nature (London) 286, 74–77.CrossRefGoogle Scholar

Quitkin, F., Rifkin, A. & Klein, D. F. (1976). Neurologic soft signs in schizophrenia and character disorders. Archives of General Psychiatry 33, 845–853.CrossRefGoogle ScholarPubMed

Robertson, G. & Taylor, P. J. (1985). Some cognitive correlates of schizophrenic illnesses. Psychological Medicine 15, 81–98.CrossRefGoogle ScholarPubMed

Rochford, J. M., Detre, T., Tucker, G. J. & Harrow, M. (1970). Neuropsychological impairments in functional psychiatric diseases. Archives of General Psychiatry 22, 114–119.CrossRefGoogle ScholarPubMed

Simpson, G. M. & Angus, J. W. S. (1970). A rating scale for extra-pyramidal side effects. Acta Psychiatrica Scandinavica 212, 44–51.CrossRefGoogle Scholar

Slater, E., Beard, A. W. & Glitherow, E. (1963). The schizophrenia-like psychoses of epilepsy. British Journal of Psychiatry 109, 95–105.CrossRefGoogle Scholar

Stack, J. T. & Phillips, A. G. (1970). Performance of medical, brain damaged and schizophrenic patients on the Halstead-Reitan neuropsychology battery. Newsletter for Research in Psychology 12, 16–18.Google Scholar

Stevens, M. (1979). Famous personality test: a test for remote memory. Bulletin of the British Psychological Society 32, 211–214.Google Scholar

Walsh, K. W. (1977). Neuropsychiatry: a Clinical Approach. Churchill Livingstone: Edinburgh.Google Scholar

Wechsler, D. (1958). The Measurement and Appraisal of Adult Intelligence (fourth edn). Williams and Wilkins: Baltimore.Google Scholar