Antidepressant actions of the exercise-regulated gene VGF (original) (raw)

References

  1. Kavanagh, T. Exercise and the heart. Ann. Acad. Med. Singapore 12, 331–337 (1983).
    CAS PubMed Google Scholar
  2. Anderson, B.J. et al. Exercise influences spatial learning in the radial arm maze. Physiol. Behav. 70, 425–429 (2000).
    Article CAS Google Scholar
  3. Kramer, A.F. et al. Ageing, fitness and neurocognitive function. Nature 400, 418–419 (1999).
    Article CAS Google Scholar
  4. Carro, E., Trejo, J.L., Busiguina, S. & Torres-Aleman, I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J. Neurosci. 21, 5678–5684 (2001).
    Article CAS Google Scholar
  5. Larson, E.B. et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann. Intern. Med. 144, 73–81 (2006).
    Article Google Scholar
  6. Greenwood, B.N. et al. Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J. Neurosci. 23, 2889–2898 (2003).
    Article CAS Google Scholar
  7. Dimeo, F., Bauer, M., Varahram, I., Proest, G. & Halter, U. Benefits from aerobic exercise in patients with major depression: a pilot study. Br. J. Sports Med. 35, 114–117 (2001).
    Article CAS Google Scholar
  8. Lai, S.M. et al. Therapeutic exercise and depressive symptoms after stroke. J. Am. Geriatr. Soc. 54, 240–247 (2006).
    Article Google Scholar
  9. Kessler, R.C. et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). J. Am. Med. Assoc. 289, 3095–3105 (2003).
    Article Google Scholar
  10. Greenberg, P.E. et al. The economic burden of depression in the United States: how did it change between 1990 and 2000? J. Clin. Psychiatry 64, 1465–1475 (2003).
    Article Google Scholar
  11. Fava, M. & Davidson, K.G. Definition and epidemiology of treatment-resistant depression. Psychiatr. Clin. North Am. 19, 179–200 (1996).
    Article CAS Google Scholar
  12. Nibuya, M., Morinobu, S. & Duman, R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15, 7539–7547 (1995).
    Article CAS Google Scholar
  13. Karssen, A.M. et al. Application of microarray technology in primate behavioral neuroscience research. Methods 38, 227–234 (2006).
    Article CAS Google Scholar
  14. Alfonso, J., Frasch, A.C. & Flugge, G. Chronic stress, depression and antidepressants: effects on gene transcription in the hippocampus. Rev. Neurosci. 16, 43–56 (2005).
    Article CAS Google Scholar
  15. Duman, R.S. Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism. Neurobiol. Aging 26 (Suppl. 1), 88–93 (2005).
    Article Google Scholar
  16. Allen, D.L. et al. Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. J. Appl. Physiol. 90, 1900–1908 (2001).
    Article CAS Google Scholar
  17. Duman, R.S., Malberg, J. & Thome, J. Neural plasticity to stress and antidepressant treatment. Biol. Psychiatry 46, 1181–1191 (1999).
    Article CAS Google Scholar
  18. Russo-Neustadt, A., Beard, R.C. & Cotman, C.W. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology 21, 679–682 (1999).
    Article CAS Google Scholar
  19. Neeper, S.A., Gomez-Pinilla, F., Choi, J. & Cotman, C.W. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726, 49–56 (1996).
    Article CAS Google Scholar
  20. Salton, S.R. et al. VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance. Front. Neuroendocrinol. 21, 199–219 (2000).
    Article CAS Google Scholar
  21. Nedivi, E., Wu, G.Y. & Cline, H.T. Promotion of dendritic growth by CPG15, an activity-induced signaling molecule. Science 281, 1863–1866 (1998).
    Article CAS Google Scholar
  22. Naeve, G.S. et al. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc. Natl. Acad. Sci. USA 94, 2648–2653 (1997).
    Article CAS Google Scholar
  23. Tong, L., Shen, H., Perreau, V.M., Balazs, R. & Cotman, C.W. Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol. Dis. 8, 1046–1056 (2001).
    Article CAS Google Scholar
  24. Eagleson, K.L., Fairfull, L.D., Salton, S.R. & Levitt, P. Regional differences in neurotrophin availability regulate selective expression of VGF in the developing limbic cortex. J. Neurosci. 21, 9315–9324 (2001).
    Article CAS Google Scholar
  25. Levi, A., Eldridge, J.D. & Paterson, B.M. Molecular cloning of a gene sequence regulated by nerve growth factor. Science 229, 393–395 (1985).
    Article CAS Google Scholar
  26. Newton, S.S. et al. Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors. J. Neurosci. 23, 10841–10851 (2003).
    Article CAS Google Scholar
  27. Hahm, S. et al. Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron 23, 537–548 (1999).
    Article CAS Google Scholar
  28. Alder, J. et al. Brain-derived neurotrophic factor–induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity. J. Neurosci. 23, 10800–10808 (2003).
    Article CAS Google Scholar
  29. Cryan, J.F., Markou, A. & Lucki, I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol. Sci. 23, 238–245 (2002).
    Article CAS Google Scholar
  30. Dulawa, S.C. & Hen, R. Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci. Biobehav. Rev. 29, 771–783 (2005).
    Article CAS Google Scholar
  31. Salton, S.R. Neurotrophins, growth-factor–regulated genes and the control of energy balance. Mt. Sinai J. Med. 70, 93–100 (2003).
    PubMed Google Scholar
  32. Vaynman, S., Ying, Z. & Gomez-Pinilla, F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur. J. Neurosci. 20, 2580–2590 (2004).
    Article Google Scholar
  33. Ying, Z., Roy, R.R., Edgerton, V.R. & Gomez-Pinilla, F. Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury. Exp. Neurol. 193, 411–419 (2005).
    Article CAS Google Scholar
  34. McEwen, B.S. & Chattarji, S. Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine. Eur. Neuropsychopharmacol. 14 (Suppl. 5), S497–S502 (2004).
    Article CAS Google Scholar
  35. Lu, B., Greengard, P. & Poo, M.M. Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron 8, 521–529 (1992).
    Article CAS Google Scholar
  36. Cui, X.S. & Kim, N.H. Polyamines inhibit apoptosis in porcine parthenotes developing in vitro. Mol. Reprod. Dev. 70, 471–477 (2005).
    Article CAS Google Scholar
  37. Newton, S.S., Collier, E.F., Bennett, A.H., Russell, D.S. & Duman, R.S. Regulation of growth factor receptor bound 2 by electroconvulsive seizure. Brain Res. Mol. Brain Res. 129, 185–188 (2004).
    Article CAS Google Scholar
  38. Kishi, T. & Elmquist, J.K. Body weight is regulated by the brain: A link between feeding and emotion. Mol. Psychiatry 10, 132–146 (2005).
    Article CAS Google Scholar
  39. Vaynman, S.S., Ying, Z., Yin, D. & Gomez-Pinilla, F. Exercise differentially regulates synaptic proteins associated to the function of BDNF. Brain Res. 1070, 124–130 (2006).
    Article CAS Google Scholar
  40. Duman, R.S. & Monteggia, L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 59, 1116–1127 (2006).
    Article CAS Google Scholar
  41. Newton, S.S., Dow, A., Terwilliger, R. & Duman, R. A simplified method for combined immunohistochemistry and in situ hybridization in fresh-frozen, cryocut mouse brain sections. Brain Res. Brain Res. Protoc. 9, 214–219 (2002).
    Article CAS Google Scholar
  42. Koo, J.W. et al. The postnatal environment can counteract prenatal effects on cognitive ability, cell proliferation, and synaptic protein expression. FASEB J. 17, 1556–1558 (2003).
    Article CAS Google Scholar

Download references