Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection (original) (raw)

• Malim, M. H. & Bieniasz, P. D. HIV restriction factors and mechanisms of evasion. Cold Spring Harb. Perspect. Med. 2, a006940 (2012)
  Article Google Scholar
• Sheehy, A. M., Gaddis, N. C., Choi, J. D. & Malim, M. H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418, 646–650 (2002)
  Article ADS CAS Google Scholar
• Stremlau, M. et al. The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys. Nature 427, 848–853 (2004)
  Article ADS CAS Google Scholar
• Neil, S. J., Zang, T. & Bieniasz, P. D. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 451, 425–430 (2008)
  Article ADS CAS Google Scholar
• Van Damme, N. et al. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 3, 245–252 (2008)
  Article CAS Google Scholar
• Hrecka, K. et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474, 658–661 (2011)
  Article CAS Google Scholar
• Laguette, N. et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474, 654–657 (2011)
  Article CAS Google Scholar
• Asmuth, D. M. et al. Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon Alfa-2a in HIV-1-monoinfected participants: a phase II clinical trial. J. Infect. Dis. 201, 1686–1696 (2010)
  Article CAS Google Scholar
• Bitzegeio, J., Sampias, M., Bieniasz, P. D. & Hatziioannou, T. Adaptation to the interferon-induced antiviral state by human and simian immunodeficiency viruses. J. Virol. 87, 3549–3560 (2013)
  Article CAS Google Scholar
• Goujon, C. & Malim, M. H. Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells. J. Virol. 84, 9254–9266 (2010)
  Article CAS Google Scholar
• Ho, D. D. et al. Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro. Lancet 325, 602–604 (1985)
  Article Google Scholar
• Meylan, P. R., Guatelli, J. C., Munis, J. R., Richman, D. D. & Kornbluth, R. S. Mechanisms for the inhibition of HIV replication by interferons-α, -β, and -γ in primary human macrophages. Virology 193, 138–148 (1993)
  Article CAS Google Scholar
• Pillai, S. K. et al. Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo. Proc. Natl Acad. Sci. USA 109, 3035–3040 (2012)
  Article ADS CAS Google Scholar
• Schoggins, J. W. et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472, 481–485 (2011)
  Article ADS CAS Google Scholar
• Haller, O. & Kochs, G. Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. J. Interferon Cytokine Res. 31, 79–87 (2011)
  Article CAS Google Scholar
• Pavlovic, J., Zurcher, T., Haller, O. & Staeheli, P. Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J. Virol. 64, 3370–3375 (1990)
  CAS PubMed PubMed Central Google Scholar
• Goujon, C. et al. Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection. Retrovirology 10, 23 (2013)
  Article CAS Google Scholar
• Sayah, D. M., Sokolskaja, E., Berthoux, L. & Luban, J. Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1. Nature 430, 569–573 (2004)
  Article ADS CAS Google Scholar
• Kim, B. H., Shenoy, A. R., Kumar, P., Bradfield, C. J. & MacMicking, J. D. IFN-inducible GTPases in host cell defense. Cell Host Microbe 12, 432–444 (2012)
  Article CAS Google Scholar
• Gao, S. et al. Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity 35, 514–525 (2011)
  Article CAS Google Scholar
• Mitchell, P. S. et al. Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. Cell Host Microbe 12, 598–604 (2012)
  Article CAS Google Scholar
• King, M. C., Raposo, G. & Lemmon, M. A. Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB. Proc. Natl Acad. Sci. USA 101, 8957–8962 (2004)
  Article ADS CAS Google Scholar
• Melén, K. et al. Human MxB protein, an interferon-α-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. J. Biol. Chem. 271, 23478–23486 (1996)
  Article Google Scholar
• Brass, A. L. et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319, 921–926 (2008)
  Article ADS CAS Google Scholar
• König, R. et al. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135, 49–60 (2008)
  Article Google Scholar
• Lee, K. et al. Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe 7, 221–233 (2010)
  Article CAS Google Scholar
• Shah, V. B. et al. The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. J. Virol. 87, 422–432 (2013)
  Article CAS Google Scholar
• Pitossi, F. et al. A functional GTP-binding motif is necessary for antiviral activity of Mx proteins. J. Virol. 67, 6726–6732 (1993)
  CAS PubMed PubMed Central Google Scholar
• Ponten, A., Sick, C., Weeber, M., Haller, O. & Kochs, G. Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. J. Virol. 71, 2591–2599 (1997)
  CAS PubMed PubMed Central Google Scholar
• Brass, A. L. et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139, 1243–1254 (2009)
  Article Google Scholar
• Adachi, A. et al. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59, 284–291 (1986)
  CAS PubMed PubMed Central Google Scholar
• Fouchier, R. A., Meyer, B. E., Simon, J. H., Fischer, U. & Malim, M. H. HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import. EMBO J. 16, 4531–4539 (1997)
  Article CAS Google Scholar
• Simon, J. H., Southerling, T. E., Peterson, J. C., Meyer, B. E. & Malim, M. H. Complementation of _vif_-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genes. J. Virol. 69, 4166–4172 (1995)
  CAS PubMed PubMed Central Google Scholar
• Schindler, M. et al. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J. Virol. 77, 10548–10556 (2003)
  Article CAS Google Scholar
• Ochsenbauer, C. et al. Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages. J. Virol. 86, 2715–2728 (2012)
  Article CAS Google Scholar
• Ryan-Graham, M. A. & Peden, K. W. Both virus and host components are important for the manifestation of a Nef− phenotype in HIV-1 and HIV-2. Virology 213, 158–168 (1995)
  Article CAS Google Scholar
• Sauter, D. et al. Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains. Cell Host Microbe 6, 409–421 (2009)
  Article CAS Google Scholar
• Soares, M. A. et al. A full-length and replication-competent proviral clone of SIVAGM from tantalus monkeys. Virology 228, 394–399 (1997)
  Article CAS Google Scholar
• Sakai, H. et al. Genetic characterization of simian immunodeficiency virus isolated from an African mandrill. Arch. Virol. 125, 1–14 (1992)
  Article CAS Google Scholar
• Gaddis, N. C. et al. Further investigation of simian immunodeficiency virus Vif function in human cells. J. Virol. 78, 12041–12046 (2004)
  Article CAS Google Scholar
• Naldini, L. et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263–267 (1996)
  Article ADS CAS Google Scholar
• Mangeot, P. E. et al. High levels of transduction of human dendritic cells with optimized SIV vectors. Mol. Ther. 5, 283–290 (2002)
  Article CAS Google Scholar
• Saenz, D. T., Teo, W., Olsen, J. C. & Poeschla, E. M. Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5α proteins. J. Virol. 79, 15175–15188 (2005)
  Article CAS Google Scholar
• O'Rourke, J. P., Newbound, G. C., Kohn, D. B., Olsen, J. C. & Bunnell, B. A. Comparison of gene transfer efficiencies and gene expression levels achieved with equine infectious anemia virus- and human immunodeficiency virus type 1-derived lentivirus vectors. J. Virol. 76, 1510–1515 (2002)
  Article CAS Google Scholar
• Jarrosson-Wuilleme, L. et al. Transduction of nondividing human macrophages with gammaretrovirus-derived vectors. J. Virol. 80, 1152–1159 (2006)
  Article CAS Google Scholar
• Schaller, T. et al. HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog. 7, e1002439 (2011)
  Article CAS Google Scholar
• Cordeil, S. et al. Evidence for a different susceptibility of primate lentiviruses to type I interferons. J. Virol. 87, 2587–2596 (2013)
  Article CAS Google Scholar
• Pear, W. S. et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 92, 3780–3792 (1998)
  CAS PubMed Google Scholar
• Mangeot, P. E. et al. Protein transfer into human cells by VSV-G-induced nanovesicles. Mol. Ther. 19, 1656–1666 (2011)
  Article CAS Google Scholar
• Wei, X. et al. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob. Agents Chemother. 46, 1896–1905 (2002)
  Article CAS Google Scholar
• Shi, W., Oshlack, A. & Smyth, G. K. Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips. Nucleic Acids Res. 38, e204 (2010)
  Article Google Scholar
• Markusic, D., Oude-Elferink, R., Das, A. T., Berkhout, B. & Seppen, J. Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter. Nucleic Acids Res. 33, e63 (2005)
  Article Google Scholar
• Trichas, G., Begbie, J. & Srinivas, S. Use of the viral 2A peptide for bicistronic expression in transgenic mice. BMC Biol. 6, 40 (2008)
  Article Google Scholar
• Donnelly, M. L. et al. Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’. J. Gen. Virol. 82, 1013–1025 (2001)
  Article CAS Google Scholar
• Bamming, D. & Horvath, C. M. Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2. J. Biol. Chem. 284, 9700–9712 (2009)
  Article CAS Google Scholar
• Yee, J. K. et al. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc. Natl Acad. Sci. USA 91, 9564–9568 (1994)
  Article ADS CAS Google Scholar
• Cauldwell, A. V., Moncorge, O. & Barclay, W. S. Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells. J. Virol. 87, 1278–1284 (2013)
  Article CAS Google Scholar
• Neumann, G. & Hobom, G. Mutational analysis of influenza virus promoter elements in vivo. J. Gen. Virol. 76, 1709–1717 (1995)
  Article CAS Google Scholar
• Pertel, T. et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 472, 361–365 (2011)
  Article ADS CAS Google Scholar
• Newman, E. N. et al. Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity. Curr. Biol. 15, 166–170 (2005)
  Article CAS Google Scholar
• O’Doherty, U., Swiggard, W. J., Jeyakumar, D., McGain, D. & Malim, M. H. A sensitive, quantitative assay for human immunodeficiency virus type 1 integration. J. Virol. 76, 10942–10950 (2002)
  Article Google Scholar