Identification of loci associated with schizophrenia by genome-wide association and follow-up (original) (raw)

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Acknowledgements

The UK research was supported by grants from the MRC and the Wellcome Trust. We are grateful to the Wellcome Trust Case Control Consortium for access to control genotypes (and to the individuals acknowledged in that respect in ref. 4) and their contribution to the genome-wide study, and to the Welsh e-Science Centre at Cardiff University for access to computing resources for some of this work. In Dublin, the research was supported by Science Foundation Ireland, the Health Research Board (Ireland) and the Wellcome Trust. We are grateful to J. Waddington for sample recruitment. Irish controls were supplied by J. McPartlin and the Trinity College Biobank. In Bonn and Mannheim, the work was supported by the National Genomic Network of the 'Bundesministerium für Bildung und Forschung' (BMBF) and the Alfried Krupp von Bohlen und Halbach-Stiftung. We also thank the Department of Psychiatry, LMU Munich for clinical characterization of the Munich subjects and the processing of the samples. Recruitment in Munich was partially supported by GlaxoSmithKline. The Ashkenazi samples are part of the Hebrew University Genetic Resource.

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Authors and Affiliations

1. Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
   Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Stanley Zammit, Nigel M Williams, George Kirov & Michael J Owen
2. Department of Statistics, University of Oxford, OX1 3TG, UK
   Jonathan L Marchini, Chris C A Spencer & Bryan Howie
3. Department of Medical Genetics, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge, CB2 0XY, UK
   Hin-Tak Leung
4. Division of Molecular and Clinical Neurobiology, Ludwig-Maximilians-University, Nuβbaumstr. 7, Munich, 80336, Germany
   Annette M Hartmann, Ina Giegling & Dan Rujescu
5. Department of Psychiatry, Ludwig-Maximilians-University, Nuβbaumstr. 7, 80336, Munich, Germany
   Hans-Jürgen Möller
6. Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College Dublin 8, Ireland
   Derek W Morris, Emma M Quinn, Michael Gill & Aiden Corvin
7. Bio-X Center, Shanghai Jiao Tong University, Shanghai, 200030, China
   YongYong Shi & Lin He
8. Shanghai Institute of Mental Health, Shanghai, 200030, China
   GuoYin Feng
9. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, 53105, Germany
   Per Hoffmann, Catalina Vasilescu, Sven Cichon & Markus M Nöthen
10. Institute of Human Genetics, University of Bonn, Bonn, 53105, Germany
    Peter Propping, Sven Cichon & Markus M Nöthen
11. Department of Psychiatry, University of Bonn, Bonn, 53105, Germany
    Wolfgang Maier
12. Division Genetic Epidemiology in Psychiatry, Central Institute for Mental Health, Mannheim, 68159, Germany
    Marcella Rietschel
13. Genetic Basis of Mood and Anxiety Disorders, US National Institute of Mental Health, National Institutes of Health, Bethesda, 20892, Maryland, USA
    Johannes Schumacher & Thomas G Schulze
14. Department of Psychiatry, Fujita Health University School of Medicine, Aichi, 470-1192, Japan
    Nakao Iwata & Masashi Ikeda
15. Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency, Saitama, 332-0012, Japan
    Nakao Iwata & Masashi Ikeda
16. Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Israel
    Ariel Darvasi & Sagiv Shifman
17. Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Lin He
18. Center for Psychiatric Genetics, Evanston Northwestern Healthcare (ENH), Evanston, 60201, Illinois, USA
    Jubao Duan, Alan R Sanders, Pablo V Gejman, Pablo V Gejman, Alan R Sanders & Jubao Duan
19. Feinberg School of Medicine, Northwestern University, Evanston, 60201, Illinois, USA
    Jubao Duan, Alan R Sanders, Pablo V Gejman, Pablo V Gejman, Alan R Sanders & Jubao Duan
20. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California, 94305, USA
    Douglas F Levinson & Douglas F Levinson
21. School of Nursing, Louisiana State University Health Sciences Center, New Orleans, 70112, Louisiana, USA
    Nancy G Buccola
22. The Queensland Centre for Mental Health Research and The Queensland Institute for Medical Research, Wacol, Queensland, 4076, Australia
    Bryan J Mowry
23. Department of Psychiatry, University of Colorado Health Sciences Center, Denver, 80262, Colorado, USA
    Robert Freedman
24. Atlanta Veterans Affairs Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University, Decatur, 30033, Georgia, USA
    Farooq Amin
25. Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City, 52242, Iowa, USA
    Donald W Black
26. Department of Psychiatry, Mount Sinai School of Medicine, New York, 10029, New York, USA
    Jeremy M Silverman
27. Department of Psychiatry, University of California San Francisco, San Francisco, 94121, California, USA
    William F Byerley
28. Departments of Psychiatry, Washington University, St. Louis, 63108, Missouri, USA
    C Robert Cloninger
29. Departments of Genetics, Washington University, St. Louis, 63108, Missouri, USA
    C Robert Cloninger

Authors

1. Michael C O'Donovan
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2. Nicholas Craddock
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3. Nadine Norton
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4. Hywel Williams
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5. Timothy Peirce
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6. Valentina Moskvina
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7. Ivan Nikolov
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8. Marian Hamshere
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9. Liam Carroll
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10. Lyudmila Georgieva
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11. Sarah Dwyer
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12. Peter Holmans
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13. Jonathan L Marchini
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14. Chris C A Spencer
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15. Bryan Howie
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16. Hin-Tak Leung
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17. Annette M Hartmann
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18. Hans-Jürgen Möller
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19. Derek W Morris
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20. YongYong Shi
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21. GuoYin Feng
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22. Per Hoffmann
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23. Peter Propping
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24. Catalina Vasilescu
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25. Wolfgang Maier
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26. Marcella Rietschel
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27. Stanley Zammit
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28. Johannes Schumacher
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29. Emma M Quinn
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30. Thomas G Schulze
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31. Nigel M Williams
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32. Ina Giegling
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33. Nakao Iwata
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34. Masashi Ikeda
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35. Ariel Darvasi
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36. Sagiv Shifman
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37. Lin He
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38. Jubao Duan
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39. Alan R Sanders
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40. Douglas F Levinson
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41. Pablo V Gejman
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42. Sven Cichon
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43. Markus M Nöthen
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44. Michael Gill
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45. Aiden Corvin
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46. Dan Rujescu
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47. George Kirov
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48. Michael J Owen
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Consortia

Molecular Genetics of Schizophrenia Collaboration

• Pablo V Gejman
• , Alan R Sanders
• , Jubao Duan
• , Douglas F Levinson
• , Nancy G Buccola
• , Bryan J Mowry
• , Robert Freedman
• , Farooq Amin
• , Donald W Black
• , Jeremy M Silverman
• , William F Byerley
• & C Robert Cloninger

Contributions

M.C.O'D., M.J.O., and N.C. directed this study and the collection of the UK sample. M.C.O'D. and M.J.O. took primary responsibility for drafting the manuscript assisted by N.N. and H.W. Collaborative scientific direction, replication sample collections, diagnoses and construction of case-control material were led by A.C., M.G., and D.W.M. (Ireland), D.R. (Munich, Germany), W.M., M.R., M.M.N., S.C., J.S. and P.P. (Bonn, Germany), G.K. (Bulgaria), L.H. and G.F. (China); N.I. (Japan) and S.S. and A.D. (Israel). J.L.M., C.C.A.S. and H.-T.L. were responsible for procedures related to calling Affymetrix genotypes. Replication genotyping was performed and analyzed by N.N., H.W., T.P., L.C., L.G. and S.D. (Cardiff); C.V. and P.Hoffmann (Bonn); Y.S. (China); S.S. (Israel); and M.I. (Japan). I.N. developed the database for the GWA project in which the data were stored, the primary analyses were performed and the results visualized. V.M. and P.Holmans supervised the association statistics to which N.N. additionally contributed. M.H. and N.C. were responsible for most of the quality control procedures. Additional scientific coordination of clinical sample collection and diagnosis was performed by S.Z., E.M.Q., A.M.H., H.-J.M., I.G. and T.G.S. All authors discussed the results and approved the manuscript.

Corresponding authors

Correspondence toMichael C O'Donovan or Michael J Owen.

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O'Donovan, M., Craddock, N., Norton, N. et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up.Nat Genet 40, 1053–1055 (2008). https://doi.org/10.1038/ng.201

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• Received: 10 March 2008
• Accepted: 27 June 2008
• Published: 30 July 2008
• Issue Date: September 2008
• DOI: https://doi.org/10.1038/ng.201