New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (original) (raw)

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• 26 March 2010

In the version of this article initially published, there were several errors in the author affiliations. These errors have been corrected in the HTML and PDF versions of the article.

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Acknowledgements

A full list of Acknowledgments appears in the Supplementary Note.

Author information

Author notes

1. Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena and Nicole Soranzo: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
   Josée Dupuis & Alisa K Manning
2. National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA
   Josée Dupuis & Caroline S Fox
3. Medical Research Council (MRC), Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
   Claudia Langenberg, Jian'an Luan, Nita G Forouhi, Manjinder Sandhu, Stephen J Sharp, Jing Hua Zhao, Ruth J F Loos & Nicholas J Wareham
4. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
   Inga Prokopenko, Anna L Gloyn, Cecilia M Lindgren, Reedik Mägi, Amanda J Bennett, Christopher J Groves, Neelam Hassanali, Paul R V Johnson, Laura J McCulloch, Matthew J Neville, Nigel W Rayner, Fredrik Karpe & Mark I McCarthy
5. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
   Inga Prokopenko, Cecilia M Lindgren, Reedik Mägi, Andrew P Morris, Joshua Randall, Anuj Goel, John F Peden, Nigel W Rayner, Hugh Watkins, Eleftheria Zeggini & Mark I McCarthy
6. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
   Richa Saxena, Benjamin F Voight, Amanda Elliott, Steven A McCarroll, Gabe Crawford, Jarred B McAteer, David Altshuler & Jose C Florez
7. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
   Richa Saxena, Benjamin F Voight, Amanda Elliott, Steven A McCarroll, David Altshuler & Jose C Florez
8. Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
   Nicole Soranzo, Suzannah J Bumpstead, Rhian Gwilliam, Naomi Hammond, Simon C Potter, Dhiraj Varma, Eleftheria Zeggini, Panos Deloukas, Timothy D Spector & Leena Peltonen
9. Twin Research and Genetic Epidemiology Department, King's College London, St. Thomas' Hospital Campus, London, UK
   Nicole Soranzo, Massimo Mangino, Guangju Zhai & Timothy D Spector
10. Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Anne U Jackson, Heather M Stringham, Xijing Han, Yun Li, Laura J Scott, Goncalo R Abecasis & Michael Boehnke
11. Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Eleanor Wheeler, Felicity Payne, Rosa Maria Roccasecca & Inês Barroso
12. Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, USA
    Nicole L Glazer
13. Centre National de la Recherche Scientifique–Unité Mixte de Recherche 8090, Pasteur Institute, Lille 2–Droit et Santé University, Lille, France
    Nabila Bouatia-Naji, Christine Cavalcanti-Proença, Amélie Bonnefond, Jerome Delplanque, Christian Dina, Olivier Le Bacquer, Cécile Lecoeur, David Meyre & Philippe Froguel
14. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    Toby Johnson & Sven Bergmann
15. University Institute of Social and Preventative Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland
    Toby Johnson & Murielle Bochud
16. Swiss Institute of Bioinformatics, Lausanne, Switzerland
    Toby Johnson & Sven Bergmann
17. Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, Norfolk Place, London, UK
    Paul Elliott, Lachlan J M Coin, Ulla Sovio & Marjo-Riitta Jarvelin
18. Boston University Data Coordinating Center, Boston, Massachusetts, USA
    Denis Rybin
19. deCODE Genetics, Reykjavik, Iceland
    Gudmar Thorleifsson, Valgerdur Steinthorsdottir, G Bragi Walters, Augustine Kong, Unnur Thorsteinsdottir & Kari Stefansson
20. Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Peter Henneman
21. Institute of Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
    Harald Grallert, Christian Gieger, Christa Meisinger, Barbara Thorand, H Erich Wichmann & Thomas Illig
22. Department of Epidemiology, Erasmus Medical College, Rotterdam, The Netherlands
    Abbas Dehghan, Albert Hofman, Fernando Rivadeneira, Eric J G Sijbrands, André G Uitterlinden, Jaqueline C M Witteman, Cornelia M van Duijn & Yurii S Aulchenko
23. Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Jouke Jan Hottenga, Eco J C de Geus, Danielle Posthuma, Gonneke Willemsen & Dorret I Boomsma
24. Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Christopher S Franklin, Sarah H Wild, Igor Rudan, Harry Campbell & James F Wilson
25. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, UK
    Pau Navarro, Caroline Hayward, Veronique Vitart & Alan F Wright
26. Division of Genetics, Research and Development, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    Kijoung Song, Dawn M Waterworth & Vincent Mooser
27. Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Anuj Goel, John F Peden & Hugh Watkins
28. Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    John R B Perry, David Melzer, Michael N Weedon & Timothy M Frayling
29. National Institute of Aging, Baltimore, Maryland, USA
    Josephine M Egan
30. Unit for Child and Adolescent Health and Welfare, National Institute for Health and Welfare, Biocenter Oulu, University of Oulu, Oulu, Finland
    Taina Lajunen
31. Hagedorn Research Institute, Gentofte, Denmark
    Niels Grarup, Thomas Sparsø, Torben Hansen & Oluf Pedersen
32. Department of Medicine and Therapeutics, Level 7, Ninewells Hospital and Medical School, Dundee, UK
    Alex Doney
33. Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Man Li & W H Linda Kao
34. Department of Nutrition–Dietetics, Harokopio University, Athens, Greece
    Stavroula Kanoni & George V Dedoussis
35. General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Peter Shrader & James B Meigs
36. Department of Epidemiology and Public Health, University College London, London, UK
    Meena Kumari, Eric Brunner, Aroon D Hingorani, Mika Kivimaki & Michael Marmot
37. Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Lu Qi & Marilyn Cornelis
38. MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK
    Nicholas J Timpson, Ian N M Day, Debbie A Lawlor & George Davey Smith
39. Fundación para la Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain
    Carina Zabena, María Teresa Martínez-Larrad & Manuel Serrano-Ríos
40. Departments of Medicine and Human Genetics, McGill University, Montreal, Canada
    Ghislain Rocheleau & Robert Sladek
41. Genome Quebec Innovation Centre, Montreal, Canada
    Ghislain Rocheleau & Robert Sladek
42. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Erik Ingelsson, Nancy L Pedersen & Patrik K E Magnusson
43. Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Erik Ingelsson & Björn Zethelius
44. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
    Ping An, Michael A Province & Ingrid B Borecki
45. Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Jeffrey O'Connell, Braxton D Mitchell, Ruth Pakyz & Alan R Shuldiner
46. INSERM U859, Universite de Lille-Nord de France, Lille, France
    François Pattou
47. Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Praveen Sethupathy, Lori L Bonnycastle, Peter Chines, Michael R Erdos, Mario A Morken, Narisu Narisu, Daniel Pearson, Amy Swift, Francis S Collins & David Schlessinger
48. The Broad Institute, Cambridge, Massachusetts, USA
    Kristin Ardlie & Leena Peltonen
49. Leiden Genome Technology Center, Leiden University Medical Center, Leiden, The Netherlands
    Yavuz Ariyurek
50. INSERM U780, Paris Sud University, Villejuif, France
    Beverley Balkau
51. The Heart Research Institute, Sydney, New South Wales, Australia
    Philip Barter
52. Department of Molecular Genetics, PathWest Laboratory of Western Australia, J Block, QEII Medical Centre, Nedlands West Australia, Australia
    John P Beilby & Jennie Hui
53. School of Surgery and Pathology, University of Western Australia, Nedlands West Australia, Australia
    John P Beilby
54. Department of Social Medicine, University of Bristol, Bristol, UK
    Yoav Ben-Shlomo
55. Landspitali University Hospital, Reykjavik, Iceland
    Rafn Benediktsson & Gunnar Sigurðsson
56. Icelandic Heart Association, Kopavogur, Iceland
    Rafn Benediktsson & Gunnar Sigurðsson
57. The Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA
    Eric Boerwinkle
58. Steno Diabetes Center, Gentofte, Denmark
    Knut Borch-Johnsen
59. Faculty of Health Science, University of Aarhus, Aarhus, Denmark
    Knut Borch-Johnsen & Oluf Pedersen
60. Department of Medicine, University of Leipzig, Leipzig, Germany
    Yvonne Böttcher, Anke Tönjes & Michael Stumvoll
61. Endocrinology–Diabetology Unit, Corbeil-Essonnes Hospital, Essonnes, France
    Guillaume Charpentier
62. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Yii-Der Ida Chen, Mark O Goodarzi & Jerome I Rotter
63. Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    Robert Clarke
64. Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Australia
    Matthew N Cooper, Annette C Fedson, Laila Simpson, Kim L Ward & Lyle J Palmer
65. Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
    Laura Crisponi, Silvia Naitza, Marco Orrù, Serena Sanna, Antonio Cao, Angelo Scuteri & Manuela Uda
66. Western Australian Sleep Disorders Research Institute, Queen Elizabeth Medical Centre II, Perth, Australia
    Annette C Fedson, David R Hillman, Sutapa Mukherjee, Laila Simpson, Kim L Ward & Lyle J Palmer
67. Department of Endocrinology, Diabetes and Nutrition, Charite-Universitaetsmedizin Berlin, Berlin, Germany
    Antje Fischer-Rosinsky, Andreas F H Pfeiffer & Joachim Spranger
68. Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
    Antje Fischer-Rosinsky, Andreas F H Pfeiffer & Joachim Spranger
69. Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Caroline S Fox & Gordon H Williams
70. Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Rune Frants & Ko Willems van Dijk
71. Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy
    Maria Grazia Franzosi
72. Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Université Paris 13, Bobigny Cedex, France
    Pilar Galan
73. Department of Medicine III, Division Prevention and Care of Diabetes, University of Dresden, Dresden, Germany
    Jürgen Graessler, Stefan R Bornstein & Peter Schwarz
74. Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Scott Grundy
75. Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Ulf Gyllensten
76. Centre Hospitalier Universitaire, de Poitiers, Endocrinologie Diabetologie, CIC INSERM 0802, INSERM U927, Université de Poitiers, Unité de Formation et de Recherche, Médecine Pharmacie, Poitiers, France
    Samy Hadjadj
77. Department of Public Health and Clinical Medicine, Section for Nutritional Research, Umeå University, Umeå, Sweden
    Göran Hallmans
78. Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland
    Anna-Liisa Hartikainen
79. Centre National de Génotypage/Institut de génomique/Commissariat á l'énergie atomique, Evry Cedex, France
    Simon C Heath, G Mark Lathrop & Diana Zelenika
80. INSERM U872, Faculté de Médecine Paris Descartes, Paris Cedex, France
    Serge Hercberg & Pierre Meneton
81. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
    Christian Herder & Michael Roden
82. Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Viale Druso, Bolzano, Italy, Affiliated Institute of the University Lübeck, Lübeck, Germany
    Andrew A Hicks, Cristian Pattaro, Irene Pichler & Peter Paul Pramstaller
83. Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Australia
    David R Hillman & Sutapa Mukherjee
84. Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Australia
    Jennie Hui & Lyle J Palmer
85. Heart Institute of Western Australia, Sir Charles Gairdner Hospital, Nedlands West Australia, Australia
    Joe Hung
86. School of Medicine and Pharmacology, University of Western Australia, Nedlands West Australia, Australia
    Joe Hung
87. Folkhalsan Research Centre, Helsinki, Finland
    Bo Isomaa & Tiinamaija Tuomi
88. Malmska Municipal Health Care Center and Hospital, Jakobstad, Finland
    Bo Isomaa
89. Nuffield Department of Surgery, University of Oxford, Oxford, UK
    Paul R V Johnson
90. Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
    Torben Jørgensen
91. Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
    Torben Jørgensen
92. National Institute for Health and Welfare, Unit of Population Studies, Turku, Finland
    Antti Jula
93. Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland
    Marika Kaakinen & Marjo-Riitta Jarvelin
94. Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Jaakko Kaprio & Jaakko Tuomilehto
95. National Institute for Health and Welfare, Unit for Child and Adolescent Mental Health, Helsinki, Finland
    Jaakko Kaprio
96. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
    Jaakko Kaprio, Markus Perola, Samuli Ripatti, Peter J Wagner, Kaisa Silander & Leena Peltonen
97. Department of Internal Medicine and Biocenter Oulu, Oulu, Finland
    Y Antero Kesaniemi
98. Diabetes Genetics, Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Beatrice Knight, Beverley Shields & Andrew T Hattersley
99. National Institute for Health and Welfare, Unit of Living Conditions, Health and Wellbeing, Helsinki, Finland
    Seppo Koskinen
100. Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
     Peter Kovacs
101. The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
     Kirsten Ohm Kyvik
102. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden
     Valeriya Lyssenko & Leif Groop
103. Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA
     Robert Mahley
104. Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
     Jarred B McAteer, David M Nathan, David Altshuler & Jose C Florez
105. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
     Jarred B McAteer, David M Nathan, Gordon H Williams, David Altshuler, James B Meigs & Jose C Florez
106. Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
     Ruth McPherson
107. Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK
     Matthew J Neville, Fredrik Karpe & Mark I McCarthy
108. Department of Clinical Genetics, Erasmus Medical College, Rotterdam, The Netherlands
     Ben A Oostra
109. Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
     Colin N A Palmer & Andrew D Morris
110. Department of Geriatric Medicine and Metabolic Disease, Second University of Naples, Naples, Italy
     Giuseppe Paolisso
111. National Institute for Health and Welfare, Unit of Public Health Genomics, Helsinki, Finland
     Markus Perola, Samuli Ripatti, Peter J Wagner, Kaisa Silander & Leena Peltonen
112. Department of Medical Genetics, University of Helsinki, Helsinki, Finland
     Markus Perola & Leena Peltonen
113. Department of Medical Statistics, Epidemiology and Medical Informatics, Andrija Stampar School of Public Health, Medical School, University of Zagreb, Rockefellerova, Zagreb, Croatia
     Ozren Polasek
114. Department of Clinical Genetics, VU University and Medical Center, Amsterdam, The Netherlands
     Danielle Posthuma
115. Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland
     Anneli Pouta
116. Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington, USA
     Bruce M Psaty
117. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
     Bruce M Psaty
118. Institute of Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
     Wolfgang Rathmann
119. Department of Biostatistics, University of Washington, Seattle, Washington, USA
     Kenneth Rice
120. Department of Internal Medicine, Erasmus Medical College, Rotterdam, The Netherlands
     Fernando Rivadeneira, Eric J G Sijbrands, André G Uitterlinden, Mandy van Hoek & M Carola Zillikens
121. Department of Metabolic Diseases, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
     Michael Roden
122. Department of Public Health and Clinical Medicine, Section for Family Medicine, Umeå University, Umeå, Sweden
     Olov Rolandsson
123. Department of General Practice, School of Public Health, University of Aarhus, Aarhus, Denmark
     Annelli Sandbaek
124. Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
     Manjinder Sandhu
125. MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
     Avan Aihie Sayer, Holly Syddall & Cyrus Cooper
126. Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA
     Paul Scheet
127. Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany
     Udo Seedorf
128. Department of Medicine, Atherosclerosis Research Unit, Karolinska Institutet, Stockholm, Sweden
     Angela Silveira
129. Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA
     Andrew Singleton
130. Department of Epidemiology, University of Washington, Seattle, Washington, USA
     Nicholas L Smith
131. Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, Washington, USA
     Nicholas L Smith
132. Department of Medical Sciences, Uppsala University, Uppsala, Sweden
     Ann-Christine Syvänen & Lars Lind
133. Medstar Research Institute, Baltimore, Maryland, USA
     Toshiko Tanaka
134. Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
     Toshiko Tanaka
135. Institut interrégional pour la santé (IRSA), La Riche, France
     Jean Tichet
136. Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
     Anke Tönjes
137. Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
     Tiinamaija Tuomi
138. Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands
     Ko Willems van Dijk
139. Research Unit, Cardiovascular Genetics, Nancy University Henri Poincaré, Nancy, France
     Sophie Visvikis-Siest
140. Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
     Nicole Vogelzangs & Brenda W J H Penninx
141. Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
     Gérard Waeber & Peter Vollenweider
142. Genomic Medicine, Imperial College London, Hammersmith Hospital, London, UK
     Andrew Walley & Philippe Froguel
143. Epidemiology and Public Health, Queen's University Belfast, Belfast, UK
     John W G Yarnell
144. Medical Products Agency, Uppsala, Sweden
     Björn Zethelius
145. National Institute for Health and Welfare, Unit of Chronic Disease Epidemiology and Prevention, Helsinki, Finland
     Veikko Salomaa
146. Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
     Frank B Hu
147. Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
     Frank B Hu
148. Department of Public Health and Clinical Medicine, Genetic Epidemiology and Clinical Research Group, Section for Medicine, Umeå University Hospital, Umeå, Sweden
     Paul W Franks
149. London School of Hygiene and Tropical Medicine, London, UK
     Shah Ebrahim
150. Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
     W H Linda Kao
151. The Welch Center for Prevention, Epidemiology, and Clinical Research, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
     W H Linda Kao
152. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
     James S Pankow
153. Department of Endocrinology and Diabetes, Norfolk and Norwich University Hospital National Health Service Trust, Norwich, UK
     Michael J Sampson
154. Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
     Johanna Kuusisto & Markku Laakso
155. Faculty of Health Science, University of Southern Denmark, Odense, Denmark
     Torben Hansen
156. Institute of Biomedical Science, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
     Oluf Pedersen
157. Department of Neurology, General Central Hospital, Bolzano, Italy
     Peter Paul Pramstaller
158. Department of Neurology, University of Lübeck, Lübeck, Germany
     Peter Paul Pramstaller
159. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
     H Erich Wichmann
160. Klinikum Grosshadern, Munich, Germany
     H Erich Wichmann
161. School of Medicine, University of Split, Split, Croatia
     Igor Rudan
162. Gen-Info Ltd., Zagreb, Croatia
     Igor Rudan
163. Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
     Richard N Bergman, Thomas A Buchanan & Richard M Watanabe
164. Department of Medicine, Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
     Thomas A Buchanan
165. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
     Karen L Mohlke
166. National Institute for Health and Welfare, Unit of Diabetes Prevention, Helsinki, Finland
     Jaakko Tuomilehto & Timo T Valle
167. South Ostrobothnia Central Hospital, Seinajoki, Finland
     Jaakko Tuomilehto
168. Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, USA
     David S Siscovick
169. Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA
     Luigi Ferrucci
170. Faculty of Medicine, University of Iceland, Reykjavík, Iceland
     Unnur Thorsteinsdottir & Kari Stefansson
171. Lab of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
     Angelo Scuteri
172. Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland
     Aimo Ruokonen
173. National Institute of Health and Welfare, Oulu, Finland
     Marjo-Riitta Jarvelin
174. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
     Richard M Watanabe
175. MRC–Health Protection Agency Centre for Environment and Health, Imperial College London, London, UK
     Paul Elliott

Authors

1. Josée Dupuis
2. Claudia Langenberg
3. Inga Prokopenko
4. Richa Saxena
5. Nicole Soranzo
6. Anne U Jackson
7. Eleanor Wheeler
8. Nicole L Glazer
9. Nabila Bouatia-Naji
10. Anna L Gloyn
11. Cecilia M Lindgren
12. Reedik Mägi
13. Andrew P Morris
14. Joshua Randall
15. Toby Johnson
16. Paul Elliott
17. Denis Rybin
18. Gudmar Thorleifsson
19. Valgerdur Steinthorsdottir
20. Peter Henneman
21. Harald Grallert
22. Abbas Dehghan
23. Jouke Jan Hottenga
24. Christopher S Franklin
25. Pau Navarro
26. Kijoung Song
27. Anuj Goel
28. John R B Perry
29. Josephine M Egan
30. Taina Lajunen
31. Niels Grarup
32. Thomas Sparsø
33. Alex Doney
34. Benjamin F Voight
35. Heather M Stringham
36. Man Li
37. Stavroula Kanoni
38. Peter Shrader
39. Christine Cavalcanti-Proença
40. Meena Kumari
41. Lu Qi
42. Nicholas J Timpson
43. Christian Gieger
44. Carina Zabena
45. Ghislain Rocheleau
46. Erik Ingelsson
47. Ping An
48. Jeffrey O'Connell
49. Jian'an Luan
50. Amanda Elliott
51. Steven A McCarroll
52. Felicity Payne
53. Rosa Maria Roccasecca
54. François Pattou
55. Praveen Sethupathy
56. Kristin Ardlie
57. Yavuz Ariyurek
58. Beverley Balkau
59. Philip Barter
60. John P Beilby
61. Yoav Ben-Shlomo
62. Rafn Benediktsson
63. Amanda J Bennett
64. Sven Bergmann
65. Murielle Bochud
66. Eric Boerwinkle
67. Amélie Bonnefond
68. Lori L Bonnycastle
69. Knut Borch-Johnsen
70. Yvonne Böttcher
71. Eric Brunner
72. Suzannah J Bumpstead
73. Guillaume Charpentier
74. Yii-Der Ida Chen
75. Peter Chines
76. Robert Clarke
77. Lachlan J M Coin
78. Matthew N Cooper
79. Marilyn Cornelis
80. Gabe Crawford
81. Laura Crisponi
82. Ian N M Day
83. Eco J C de Geus
84. Jerome Delplanque
85. Christian Dina
86. Michael R Erdos
87. Annette C Fedson
88. Antje Fischer-Rosinsky
89. Nita G Forouhi
90. Caroline S Fox
91. Rune Frants
92. Maria Grazia Franzosi
93. Pilar Galan
94. Mark O Goodarzi
95. Jürgen Graessler
96. Christopher J Groves
97. Scott Grundy
98. Rhian Gwilliam
99. Ulf Gyllensten
100. Samy Hadjadj
101. Göran Hallmans
102. Naomi Hammond
103. Xijing Han
104. Anna-Liisa Hartikainen
105. Neelam Hassanali
106. Caroline Hayward
107. Simon C Heath
108. Serge Hercberg
109. Christian Herder
110. Andrew A Hicks
111. David R Hillman
112. Aroon D Hingorani
113. Albert Hofman
114. Jennie Hui
115. Joe Hung
116. Bo Isomaa
117. Paul R V Johnson
118. Torben Jørgensen
119. Antti Jula
120. Marika Kaakinen
121. Jaakko Kaprio
122. Y Antero Kesaniemi
123. Mika Kivimaki
124. Beatrice Knight
125. Seppo Koskinen
126. Peter Kovacs
127. Kirsten Ohm Kyvik
128. G Mark Lathrop
129. Debbie A Lawlor
130. Olivier Le Bacquer
131. Cécile Lecoeur
132. Yun Li
133. Valeriya Lyssenko
134. Robert Mahley
135. Massimo Mangino
136. Alisa K Manning
137. María Teresa Martínez-Larrad
138. Jarred B McAteer
139. Laura J McCulloch
140. Ruth McPherson
141. Christa Meisinger
142. David Melzer
143. David Meyre
144. Braxton D Mitchell
145. Mario A Morken
146. Sutapa Mukherjee
147. Silvia Naitza
148. Narisu Narisu
149. Matthew J Neville
150. Ben A Oostra
151. Marco Orrù
152. Ruth Pakyz
153. Colin N A Palmer
154. Giuseppe Paolisso
155. Cristian Pattaro
156. Daniel Pearson
157. John F Peden
158. Nancy L Pedersen
159. Markus Perola
160. Andreas F H Pfeiffer
161. Irene Pichler
162. Ozren Polasek
163. Danielle Posthuma
164. Simon C Potter
165. Anneli Pouta
166. Michael A Province
167. Bruce M Psaty
168. Wolfgang Rathmann
169. Nigel W Rayner
170. Kenneth Rice
171. Samuli Ripatti
172. Fernando Rivadeneira
173. Michael Roden
174. Olov Rolandsson
175. Annelli Sandbaek
176. Manjinder Sandhu
177. Serena Sanna
178. Avan Aihie Sayer
179. Paul Scheet
180. Laura J Scott
181. Udo Seedorf
182. Stephen J Sharp
183. Beverley Shields
184. Gunnar Sigurðsson
185. Eric J G Sijbrands
186. Angela Silveira
187. Laila Simpson
188. Andrew Singleton
189. Nicholas L Smith
190. Ulla Sovio
191. Amy Swift
192. Holly Syddall
193. Ann-Christine Syvänen
194. Toshiko Tanaka
195. Barbara Thorand
196. Jean Tichet
197. Anke Tönjes
198. Tiinamaija Tuomi
199. André G Uitterlinden
200. Ko Willems van Dijk
201. Mandy van Hoek
202. Dhiraj Varma
203. Sophie Visvikis-Siest
204. Veronique Vitart
205. Nicole Vogelzangs
206. Gérard Waeber
207. Peter J Wagner
208. Andrew Walley
209. G Bragi Walters
210. Kim L Ward
211. Hugh Watkins
212. Michael N Weedon
213. Sarah H Wild
214. Gonneke Willemsen
215. Jaqueline C M Witteman
216. John W G Yarnell
217. Eleftheria Zeggini
218. Diana Zelenika
219. Björn Zethelius
220. Guangju Zhai
221. Jing Hua Zhao
222. M Carola Zillikens
223. Ingrid B Borecki
224. Ruth J F Loos
225. Pierre Meneton
226. Patrik K E Magnusson
227. David M Nathan
228. Gordon H Williams
229. Andrew T Hattersley
230. Kaisa Silander
231. Veikko Salomaa
232. George Davey Smith
233. Stefan R Bornstein
234. Peter Schwarz
235. Joachim Spranger
236. Fredrik Karpe
237. Alan R Shuldiner
238. Cyrus Cooper
239. George V Dedoussis
240. Manuel Serrano-Ríos
241. Andrew D Morris
242. Lars Lind
243. Lyle J Palmer
244. Frank B Hu
245. Paul W Franks
246. Shah Ebrahim
247. Michael Marmot
248. W H Linda Kao
249. James S Pankow
250. Michael J Sampson
251. Johanna Kuusisto
252. Markku Laakso
253. Torben Hansen
254. Oluf Pedersen
255. Peter Paul Pramstaller
256. H Erich Wichmann
257. Thomas Illig
258. Igor Rudan
259. Alan F Wright
260. Michael Stumvoll
261. Harry Campbell
262. James F Wilson

Consortia

DIAGRAM Consortium

GIANT Consortium

Global BPgen Consortium

Anders Hamsten on behalf of Procardis Consortium

the MAGIC investigators

• Richard N Bergman
• , Thomas A Buchanan
• , Francis S Collins
• , Karen L Mohlke
• , Jaakko Tuomilehto
• , Timo T Valle
• , David Altshuler
• , Jerome I Rotter
• , David S Siscovick
• , Brenda W J H Penninx
• , Dorret I Boomsma
• , Panos Deloukas
• , Timothy D Spector
• , Timothy M Frayling
• , Luigi Ferrucci
• , Augustine Kong
• , Unnur Thorsteinsdottir
• , Kari Stefansson
• , Cornelia M van Duijn
• , Yurii S Aulchenko
• , Antonio Cao
• , Angelo Scuteri
• , David Schlessinger
• , Manuela Uda
• , Aimo Ruokonen
• , Marjo-Riitta Jarvelin
• , Dawn M Waterworth
• , Peter Vollenweider
• , Leena Peltonen
• , Vincent Mooser
• , Goncalo R Abecasis
• , Nicholas J Wareham
• , Robert Sladek
• , Philippe Froguel
• , Richard M Watanabe
• , James B Meigs
• , Leif Groop
• , Michael Boehnke
• , Mark I McCarthy
• , Jose C Florez
• & Inês Barroso

Contributions

A full list of Author Contributions appears in the Supplementary Note.

Corresponding authors

Correspondence toMichael Boehnke, Mark I McCarthy, Jose C Florez or Inês Barroso.

Ethics declarations

Competing interests

J.B.M. currently has research grants from GlaxoSmithKline and Sanofi-Aventis, and serves on consultancy boards for Eli Lilly and Interleukin Genetics. J.C.F. has received consulting honoraria from Merck, Pfizer, bioStrategies, XOMA and Publicis Healthcare Communications Group, a global advertising agency engaged by Amylin Pharmaceuticals. deCODE authors are employees at deCODE genetics and own stock or stock options in the company. P.W.F. has received consulting honoraria from Unilever. P.V. and G.W. received financial support from GlaxoSmithKline to build the CoLaus study. V.M., K.S. and D.M.W. are all full-time employees at GlaxoSmithKline. I.B. and spouse own stock in GlaxoSmithKline and Incyte.

Additional information

See Supplementary Note for a full list of authors.

See Supplementary Note for a full list of authors.

See Supplementary Note for a full list of authors.

Supplementary information

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Dupuis, J., Langenberg, C., Prokopenko, I. et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.Nat Genet 42, 105–116 (2010). https://doi.org/10.1038/ng.520

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• Received: 13 August 2009
• Accepted: 14 October 2009
• Published: 17 January 2010
• Issue date: February 2010
• DOI: https://doi.org/10.1038/ng.520