RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2 (original) (raw)

• Massague J . Sorting out breast-cancer gene signatures. N Engl J Med 2007; 356: 294–297.
  Article CAS Google Scholar
• Steeg PS . Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12: 895–904.
  Article CAS Google Scholar
• Smith SC, Theodorescu D . Learning therapeutic lessons from metastasis suppressor proteins. Nat Rev Cancer 2009; 9: 253–264.
  Article CAS Google Scholar
• Fu Z, Smith PC, Zhang L, Rubin MA, Dunn RL, Yao Z et al. Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst 2003; 95: 878–889.
  Article CAS Google Scholar
• Fu Z, Kitagawa Y, Shen R, Shah R, Mehra R, Rhodes D et al. Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer. Prostate 2006; 66: 248–256.
  Article CAS Google Scholar
• Al-Mulla F, Hagan S, Behbehani AI, Bitar MS, George SS, Going JJ et al. Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin Oncol 2006; 24: 5672–5679.
  Article CAS Google Scholar
• Minoo P, Zlobec I, Baker K, Tornillo L, Terracciano L, Jass JR et al. Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer. Am J Clin Pathol 2007; 127: 820–827.
  Article Google Scholar
• Yun J, Frankenberger CA, Kuo WL, Boelens MC, Eves EM, Cheng N et al. Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer. EMBO J 2011; 30: 4500–4514.
  Article CAS Google Scholar
• Hagan S, Al-Mulla F, Mallon E, Oien K, Ferrier R, Gusterson B et al. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res 2005; 11: 7392–7397.
  Article CAS Google Scholar
• Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, Hammond SM et al. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J 2009; 28: 347–358.
  Article CAS Google Scholar
• Xu YF, Yi Y, Qiu SJ, Gao Q, Li YW, Dai CX et al. PEBP1 downregulation is associated to poor prognosis in HCC related to hepatitis B infection. J Hepatol 2010; 53: 872–879.
  Article CAS Google Scholar
• Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 1999; 401: 173–177.
  Article CAS Google Scholar
• Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M, Rosner MR . Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem 2003; 278: 13061–13068.
  Article CAS Google Scholar
• Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593–601.
  Article CAS Google Scholar
• Park SM, Gaur AB, Lengyel E, Peter ME . The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008; 22: 894–907.
  Article CAS Google Scholar
• Erler JT, Bennewith KL, Nicolau M, Dornhofer N, Kong C, Le QT et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006; 440: 1222–1226.
  Article CAS Google Scholar
• Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 2009; 15: 35–44.
  Article CAS Google Scholar
• Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003; 3: 537–549.
  Article CAS Google Scholar
• Huang da W, Sherman BT, Lempicki RA . Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44–57.
  Article Google Scholar
• Krek A, Grun D, Poy MN, Wolf R, Rosenberg L, Epstein EJ et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37: 495–500.
  Article CAS Google Scholar
• Lewis BP, Burge CB, Bartel DP . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15–20.
  Article CAS Google Scholar
• John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS . Human MicroRNA targets. PLoS Biol 2004; 2: e363.
  Article Google Scholar
• Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ . miRBase: tools for microRNA genomics. Nucleic Acids Res 2008; 36: D154–D158.
  Article CAS Google Scholar
• Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E . The role of site accessibility in microRNA target recognition. Nat Genet 2007; 39: 1278–1284.
  Article CAS Google Scholar
• Efron B, Tibshirani R . On testing the significance of sets of genes. Ann Appl Stat 2007; 1: 107–129.
  Article Google Scholar
• Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435: 834–838.
  Article CAS Google Scholar
• Csiszar K . Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol 2001; 70: 1–32.
  Article CAS Google Scholar
• Schuetz CS, Bonin M, Clare SE, Nieselt K, Sotlar K, Walter M et al. Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis. Cancer Res 2006; 66: 5278–5286.
  Article CAS Google Scholar
• Peter ME . Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle 2009; 8: 843–852.
  Article CAS Google Scholar
• Li Y, VandenBoom TG 2nd, Kong D, Wang Z, Ali S, Philip PA et al. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res 2009; 69: 6704–6712.
  Article CAS Google Scholar
• Morishita A, Zaidi M, Mitoro A, Sankarasharma D, Szabolcs M, Okada Y et al. HMGA2 is an in vivo driver of tumor metastasis. Cancer Res 2013; 73: 4289–4299.
  Article CAS Google Scholar
• Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 2009; 11: 1487–1495.
  Article CAS Google Scholar
• Lambaerts K, Wilcox-Adelman SA, Zimmermann P . The signaling mechanisms of syndecan heparan sulfate proteoglycans. Curr Opin Cell Biol 2009; 21: 662–669.
  Article CAS Google Scholar
• Barbareschi M, Maisonneuve P, Aldovini D, Cangi MG, Pecciarini L, Angelo Mauri F et al. High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis. Cancer 2003; 98: 474–483.
  Article Google Scholar
• Loussouarn D, Campion L, Sagan C, Frenel JS, Dravet F, Classe JM et al. Prognostic impact of syndecan-1 expression in invasive ductal breast carcinomas. Br J Cancer 2008; 98: 1993–1998.
  Article CAS Google Scholar
• Nikolova V, Koo CY, Ibrahim SA, Wang Z, Spillmann D, Dreier R et al. Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Carcinogenesis 2009; 30: 397–407.
  Article CAS Google Scholar
• De Oliveira T, Abiatari I, Raulefs S, Sauliunaite D, Erkan M, Kong B et al. Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype. Mol Cancer 2012; 11: 19.
  Article CAS Google Scholar
• Park H, Kim Y, Lim Y, Han I, Oh ES . Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells. J Biol Chem 2002; 277: 29730–29736.
  Article CAS Google Scholar
• Popovic A, Demirovic A, Spajic B, Stimac G, Kruslin B, Tomas D . Expression and prognostic role of syndecan-2 in prostate cancer. Prostate Cancer Prostatic Dis 2010; 13: 78–82.
  Article CAS Google Scholar
• Marion A, Dieudonne FX, Patino-Garcia A, Lecanda F, Marie PJ, Modrowski D . Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. Int J Cancer 2012; 130: 2514–2525.
  Article CAS Google Scholar
• Minn AJ, Bevilacqua E, Yun J, Rosner MR . Identification of novel metastasis suppressor signaling pathways for breast cancer. Cell Cycle 2012; 11: 2452–2457.
  Article CAS Google Scholar
• Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP . Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 2003; 31: e15.
  Article Google Scholar
• Team RDC R: A language and environment for statistical computing. 2009.
• Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5: R80.
  Article Google Scholar
• Ritchie ME, Silver J, Oshlack A, Holmes M, Diyagama D, Holloway A et al. A comparison of background correction methods for two-colour microarrays. Bioinformatics 2007; 23: 2700–2707.
  Article CAS Google Scholar
• Berger JA, Hautaniemi S, Jarvinen AK, Edgren H, Mitra SK, Astola J . Optimized LOWESS normalization parameter selection for DNA microarray data. BMC Bioinformatics 2004; 5: 194.
  Article Google Scholar
• Li Z, Lu J, Sun M, Mi S, Zhang H, Luo RT et al. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 2008; 105: 15535–15540.
  Article CAS Google Scholar
• Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S et al. Blockade of miR-150 maturation by MLL-Fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell 2012; 22: 524–535.
  Article CAS Google Scholar
• Sun M, Song CX, Huang H, Frankenberger CA, Sankarasharma D, Gomes S et al. HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci USA 2013; 110: 9920–9925.
  Article CAS Google Scholar
• Minn AJ, Gupta GP, Padua D, Bos P, Nguyen DX, Nuyten D et al. Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci USA 2007; 104: 6740–6745.
  Article CAS Google Scholar
• Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD et al. Genes that mediate breast cancer metastasis to lung. Nature 2005; 436: 518–524.
  CAS PubMed PubMed Central Google Scholar
• Enerly E, Steinfeld I, Kleivi K, Leivonen SK, Aure MR, Russnes HG et al. miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors. PLoS One 2011; 6: e16915.
  Article CAS Google Scholar
• Miller LD, Smeds J, George J, Vega VB, Vergara L, Ploner A et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci USA 2005; 102: 13550–13555.
  Article CAS Google Scholar
• Desmedt C, Piette F, Loi S, Wang Y, Lallemand F, Haibe-Kains B et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res 2007; 13: 3207–3214.
  Article CAS Google Scholar
• Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 2005; 365: 671–679.
  Article CAS Google Scholar