- Siegel R, Ma J, Zou Z, Jemal A . Cancer statistics, 2014. CA Cancer J Clin 2014; 64: 9–29.
Article PubMed Google Scholar
- Gibbons DL, Lin W, Creighton CJ, Zheng S, Berel D, Yang Y et al. Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS One 2009; 4: e5401.
Article PubMed PubMed Central Google Scholar
- Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ et al. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev 2009; 23: 2140–2151.
Article CAS PubMed PubMed Central Google Scholar
- Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593–601.
Article CAS PubMed Google Scholar
- Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S et al. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 2011; 22: 1686–1698.
Article CAS PubMed PubMed Central Google Scholar
- Yang J, Weinberg RA . Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008; 14: 818–829.
Article CAS PubMed Google Scholar
- Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 2009; 11: 1487–1495.
Article CAS PubMed Google Scholar
- Ma L, Weinberg RA . Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet 2008; 24: 448–456.
Article CAS PubMed Google Scholar
- Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, Carneiro F et al. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 2012; 31: 2062–2074.
Article CAS PubMed Google Scholar
- Kundu ST, Byers LA, Peng DH, Roybal JD, Diao L, Wang J et al. The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. Oncogene 2015; 35: 173–186.
Article PubMed PubMed Central Google Scholar
- Roybal JD, Zang Y, Ahn YH, Yang Y, Gibbons DL, Baird BN et al. miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1. Mol Cancer Res 2011; 9: 25–35.
Article CAS PubMed Google Scholar
- Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 2009; 139: 891–906.
Article CAS PubMed PubMed Central Google Scholar
- Egeblad M, Rasch MG, Weaver VM . Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol 2010; 22: 697–706.
Article CAS PubMed PubMed Central Google Scholar
- Streuli CH, Bailey N, Bissell MJ . Control of mammary epithelial differentiation - basement-membrane induces tissue-specific gene-expression in the absence of cell cell-interaction and morphological polarity. J Cell Biol 1991; 115: 1383–1395.
Article CAS PubMed Google Scholar
- Gill BJ, Gibbons DL, Roudsari LC, Saik JE, Rizvi ZH, Roybal JD et al. A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. Cancer Res 2012; 72: 6013–6023.
Article CAS PubMed PubMed Central Google Scholar
- Gilkes DM, Semenza GL, Wirtz D . Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer 2014; 14: 430–439.
Article CAS PubMed PubMed Central Google Scholar
- Ungewiss C, Rizvi ZH, Roybal JD, Peng DH, Gold KA, Shin DH et al. The microRNA-200/Zeb1 axis regulates ECM-dependent beta1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL. Sci Rep 2016; 6: 18652.
Article CAS PubMed PubMed Central Google Scholar
- Jung HY, Fattet L, Yang J . Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis. Clin Cancer Res 2015; 21: 962–968.
Article CAS PubMed Google Scholar
- Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ . Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol 2008; 38: 95–104.
Article CAS PubMed Google Scholar
- Leight JL, Wozniak MA, Chen S, Lynch ML, Chen CS . Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition. Mol Biol Cell 2012; 23: 781–791.
Article CAS PubMed PubMed Central Google Scholar
- Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 2005; 8: 241–254.
Article CAS PubMed Google Scholar
- Erler JT, Bennewith KL, Nicolau M, Dornhofer N, Kong C, Le QT et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006; 440: 1222–1226.
Article CAS PubMed Google Scholar
- Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G et al. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis. Cancer Res 2013; 73: 1721–1732.
Article CAS PubMed PubMed Central Google Scholar
- Kagan HM, Li W . Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem 2003; 88: 660–672.
Article CAS PubMed Google Scholar
- Barker HE, Cox TR, Erler JT . The rationale for targeting the LOX family in cancer. Nat Rev Cancer 2012; 12: 540–552.
Article CAS PubMed Google Scholar
- Gao Y, Xiao Q, Ma H, Li L, Liu J, Feng Y et al. LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci USA 2010; 107: 18892–18897.
Article CAS PubMed PubMed Central Google Scholar
- Han X, Li F, Fang Z, Gao Y, Li F, Fang R et al. Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun 2014; 5: 3261.
Article PubMed Google Scholar
- Byers LA, Diao L, Wang J, Saintigny P, Girard L, Peyton M et al. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res 2013; 19: 279–290.
Article CAS PubMed Google Scholar
- Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez HM, Oyasu M et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med 2010; 16: 1009–1017.
Article CAS PubMed Google Scholar
- Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A et al. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-beta-deficient mouse mammary carcinomas. Cancer Res 2013; 73: 5336–5346.
Article CAS PubMed PubMed Central Google Scholar
- Peng L, Ran YL, Hu H, Yu L, Liu Q, Zhou Z et al. Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. Carcinogenesis 2009; 30: 1660–1669.
Article CAS PubMed Google Scholar
- Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP et al. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest 2012; 122: 3170–3183.
Article CAS PubMed PubMed Central Google Scholar
- Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun 2014; 5: 5241.
Article CAS PubMed Google Scholar
- Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest 2014; 124: 2696–2708.
Article CAS PubMed PubMed Central Google Scholar
- Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganathan N et al. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest 2011; 121: 1373–1385.
Article CAS PubMed PubMed Central Google Scholar
- Palamakumbura AH, Trackman PC . A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples. Anal Biochem 2002; 300: 245–251.
Article CAS PubMed Google Scholar
- Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan HM, Baruch Y et al. Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. J Hepatol 2005; 43: 499–507.
Article CAS PubMed Google Scholar
- Hollosi P, Yakushiji JK, Fong KS, Csiszar K, Fong SF . Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. Int J Cancer 2009; 125: 318–327.
Article CAS PubMed Google Scholar
- Zhan P, Shen XK, Qian Q, Zhu JP, Zhang Y, Xie HY et al. Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas. Med Oncol 2012; 29: 648–655.
Article CAS PubMed Google Scholar
- Payne SL, Hendrix MJ, Kirschmann DA . Paradoxical roles for lysyl oxidases in cancer–a prospect. J Cell Biochem 2007; 101: 1338–1354.
Article CAS PubMed Google Scholar
- Hong HH, Pischon N, Santana RB, Palamakumbura AH, Chase HB, Gantz D et al. A role for lysyl oxidase regulation in the control of normal collagen deposition in differentiating osteoblast cultures. J Cell Physiol 2004; 200: 53–62.
Article CAS PubMed Google Scholar
- Peinado H, Moreno-Bueno G, Hardisson D, Perez-Gomez E, Santos V, Mendiola M et al. Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas. Cancer Res 2008; 68: 4541–4550.
Article CAS PubMed Google Scholar
- Kalluri R, Weinberg RA . The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420–1428.
Article CAS PubMed PubMed Central Google Scholar
- Alderton GK . Metastasis: epithelial to mesenchymal and back again. Nat Rev Cancer 2013; 13: 3.
Article PubMed Google Scholar
- Xiao D, He J . Epithelial mesenchymal transition and lung cancer. J Thorac Dis 2010; 2: 154–159.
CAS PubMed PubMed Central Google Scholar
- Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF et al. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst 2011; 103: 407–424.
Article CAS PubMed Google Scholar
- Barker HE, Bird D, Lang G, Erler JT . Tumor-secreted LOXL2 activates fibroblasts through FAK signaling. Mol Cancer Res 2013; 11: 1425–1436.
Article CAS PubMed Google Scholar
- Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M et al. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution. Cancer Res 2011; 71: 1561–1572.
Article CAS PubMed Google Scholar
- Fong SF, Dietzsch E, Fong KS, Hollosi P, Asuncion L, He Q et al. Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors. Genes Chromosomes Cancer 2007; 46: 644–655.
Article CAS PubMed Google Scholar
- Lucero HA, Kagan HM . Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell Mol Life Sci 2006; 63: 2304–2316.
Article CAS PubMed Google Scholar
- Canesin G, Cuevas EP, Santos V, Lopez-Menendez C, Moreno-Bueno G, Huang Y et al. Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization. Oncogene 2015; 34: 951–964.
Article CAS PubMed Google Scholar
- Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, Csiszar K, Fong KS, Vega S et al. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J 2005; 24: 3446–3458.
Article CAS PubMed PubMed Central Google Scholar
- Akbani R, Ng PK, Werner HM, Shahmoradgoli M, Zhang F, Ju Z et al. A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun 2014; 5: 3887.
Article CAS PubMed Google Scholar
- Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S et al. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 2014; 158: 929–944.
Article CAS PubMed PubMed Central Google Scholar
- Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP et al. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res 2013; 11: 638–650.
Article CAS PubMed PubMed Central Google Scholar
- Oliver WC, Pharr GM . An improved technique for determining hardness and elastic-modulus using load and displacement sensing indentation experiments. J Mater Res 1992; 7: 1564–1583.
Article CAS Google Scholar
- Rossi MA, Abreu MA, Santoro LB . Connective tissue skeleton of the human heart: a demonstration by cell-maceration scanning electron microscope method. Circulation 1998; 97: 934–935.
Article CAS PubMed Google Scholar
- Chaudhuri BB, Kundu P, Sarkar N . Detection and gradation of oriented texture. Pattern Recogn Lett 1993; 14: 147–153.
Article Google Scholar