Nutritional Status and Serum Cytokine Profiles in Children, Adolescents, and Young Adults with Schistosoma japonicum–Associated Hepatic Fibrosis, in Leyte, Philippines (original) (raw)
Journal Article
1International Health Institute, Brown University, Providence, Rhode Island;
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1International Health Institute, Brown University, Providence, Rhode Island;
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2Research Institute of Tropical Medicine, Manila, Philippines
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2Research Institute of Tropical Medicine, Manila, Philippines
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1International Health Institute, Brown University, Providence, Rhode Island;
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1International Health Institute, Brown University, Providence, Rhode Island;
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1International Health Institute, Brown University, Providence, Rhode Island;
Search for other works by this author on:
1International Health Institute, Brown University, Providence, Rhode Island;
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1International Health Institute, Brown University, Providence, Rhode Island;
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2Research Institute of Tropical Medicine, Manila, Philippines
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Received:
08 November 2004
Accepted:
11 February 2005
Published:
01 August 2005
Cite
Hannah M. Coutinho, Stephen T. McGarvey, Luz P. Acosta, Daria L. Manalo, Gretchen C. Langdon, Tjalling Leenstra, Hemal K. Kanzaria, Julie Solomon, Haiwei Wu, Remigio M. Olveda, Jonathan D. Kurtis, Jennifer F. Friedman, Nutritional Status and Serum Cytokine Profiles in Children, Adolescents, and Young Adults with _Schistosoma japonicum_–Associated Hepatic Fibrosis, in Leyte, Philippines, The Journal of Infectious Diseases, Volume 192, Issue 3, 1 August 2005, Pages 528–536, https://doi.org/10.1086/430929
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Abstract
In a cross-sectional study of 641 _Schistosoma japonicum_–infected individuals in Leyte, Philippines, who were 7–30 years old, we determined the grade of hepatic fibrosis (HF) by ultrasound and used anthropometric measurements and hemoglobin levels to assess nutritional status. Serum levels of interleukin (IL)-1, IL-6, and IL-10; tumor-necrosis factor (TNF)–α; soluble TNF-α receptor I; and C-reactive protein (CRP) were measured to examine the association between these markers of inflammation and HF grade. HF was present in 8.9% of the cohort; the majority of cases were mild (grade I), and severe (grade II or grade III) cases occurred only in male individuals. Compared with individuals without HF, those with severe HF—and, to a lesser degree, those with mild HF—had a significantly lower body-mass index (BMI) and BMI _z_-score, a higher prevalence of anemia, and a higher level of CRP and were more likely to produce IL-6; furthermore, those with severe HF had a significantly higher level of IL-1, compared with those either without HF or with mild HF. These findings suggest that even mild HF is associated with nutritional morbidity and underscore the importance of early recognition and treatment. In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL-1 and IL-6, HF causes undernutrition and anemia
© 2005 by the Infectious Diseases Society of America
Topic:
- anemia
- cytokine
- tumor necrosis factors
- body mass index procedure
- inflammatory markers
- ultrasonography
- interleukin-1
- heart failure
- adolescent
- hepatic fibrosis
- child
- malnutrition
- interleukin-10
- interleukins
- philippines
- c-reactive protein
- interleukin-6
- morbidity
- nutritional status
- schistosoma japonicum
- hemoglobin measurement
- tumor necrosis
- young adult
- anthropometric measures
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Nutritional Status and Serum Cytokine Profiles in Children, Adolescents, and Young Adults with _Schistosoma japonicum_–Associated Hepatic Fibrosis, in Leyte, Philippines
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