Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice (original) (raw)

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1Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista, SP, Brazil

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1Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista, SP, Brazil

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1Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista, SP, Brazil

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2Laboratório Multidisciplinar de Pesquisa, Universidade São Francisco

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3Laboratório de Plasticidade Neural e Fitoterápicos, Universidade São Francisco

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4Departamento de Nutrição, Escola de Saúde Publica, Universidade de São Paulo, São Paulo, SP, Brazil

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1Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista, SP, Brazil

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Received:

26 October 2007

Revision received:

05 December 2007

Accepted:

31 January 2008

Published:

27 February 2008

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Daniel D. C. Miranda, Demétrius P. Arçari, José Pedrazzoli, Patrícia de O. Carvalho, Suzete M. Cerutti, Deborah H. M. Bastos, Marcelo L. Ribeiro, Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice, Mutagenesis, Volume 23, Issue 4, July 2008, Pages 261–265, https://doi.org/10.1093/mutage/gen011
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Abstract

Yerba mate (Ilex paraguariensis) is rich in several bioactive compounds that can act as free radical scavengers. Since oxidative DNA damage is involved in various pathological states such as cancer, the aim of this study was to evaluate the antioxidant activity of mate tea as well as the ability to influence DNA repair in male Swiss mice. Forty animals were randomly assigned to four groups. The animals received three different doses of mate tea aqueous extract, 0.5, 1.0 or 2.0 g/kg, for 60 days. After intervention, the liver, kidney and bladder cells were isolated and the DNA damage induced by H2O2 was investigated by the comet assay. The DNA repair process was also investigated for its potential to protect the cells from damage by the same methodology. The data presented here show that mate tea is not genotoxic in liver, kidney and bladder cells. The regular ingestion of mate tea increased the resistance of DNA to H2O2-induced DNA strand breaks and improved the DNA repair after H2O2 challenge in liver cells, irrespective of the dose ingested. These results suggest that mate tea could protect against DNA damage and enhance the DNA repair activity. Protection may be afforded by the antioxidant activity of the mate tea's bioactive compounds.

© The Author 2008. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

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