An unusually compact ribosomal DNA repeat in the protozoan Giardia lamblia (original) (raw)
Journal Article
1
Department of Medical Microbiology, Stanford University School of Medicine
Stanford, CA 94306
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2
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California
San Francisco, CA 94143
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1
Department of Medical Microbiology, Stanford University School of Medicine
Stanford, CA 94306
3
Department of Microbiology and Immunology, School of Medicine, University of California
Los Angeles, CA 90024, USA
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2
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California
San Francisco, CA 94143
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Received:
12 January 1987
Revision received:
29 April 1987
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John C. Boothroyd, Alice Wang, David A. Campbell, Ching C. Wang, An unusually compact ribosomal DNA repeat in the protozoan Giardia lamblia, Nucleic Acids Research, Volume 15, Issue 10, 26 May 1987, Pages 4065–4084, https://doi.org/10.1093/nar/15.10.4065
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Abstract
The ribosomal RNA (rRNA) genes of the protozoan parasite Giardia lamblia have been analyzed with respect to size, composition and copy number. They are found to be remarkable in several respects. First, the rRNAs themselves are the smallest yet reported for any eukaryotic organism. Second, the genes encoding them are found as an exceptionally small tandemly repeated unit of only 5.4 kilobase-pairs. Third, the genes are extraordinarily G:C rich, even in regions which are highly conserved between all other eukaryotic rRNA genes. Finally, by analogy to other organisms, the 5.8S RNA appears to lack about 15 nucleotides from its 3'-end, a region previously thought to be essential for 5.8S RNA function. We also provide the first estimates of the genomic complexity and total G:C content of this important protozoan pathogen.
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