Fine Structural Observations of Neurofilamentous Changes in Amyotrophic Lateral Sclerosis (original) (raw)

Journal Article

,

Bluestone Laboratory of the Division of Neuropathology, Department of Pathology,

Montefiore Medical Center

, Bronx, NY

Correspondence to: Asao Hirano, M.D., Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467

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St. Vincent's Hospital and Medical Center

, 153 West 11th Street, New York, NY

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,

Bluestone Laboratory of the Division of Neuropathology, Department of Pathology,

Montefiore Medical Center

, Bronx, NY

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Bluestone Laboratory of the Division of Neuropathology, Department of Pathology,

Montefiore Medical Center

, Bronx, NY

Search for other works by this author on:

Published:

01 September 1984

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Asao Hirano, Hyman Donnenfeld, Shoichi Sasaki, Imaharu Nakano, Fine Structural Observations of Neurofilamentous Changes in Amyotrophic Lateral Sclerosis, Journal of Neuropathology & Experimental Neurology, Volume 43, Issue 5, September 1984, Pages 461–470, https://doi.org/10.1097/00005072-198409000-00001
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Abstract

Twenty-two of 32 sporadic cases of amyotrophic lateral sclerosis had argyrophilic spheroids, 20 micrometers or larger, in the anterior horns of the spinal cords. The fine structure of these spherical bodies was characterized by interwoven, small bundles of 10 nm neurofilaments. Scattered mitochondria, vesicles and fragments of smooth endoplasmic reticulum were commonly found among the bundles of neurofilaments. The spheroids were present not only in the myelinated axons, but also in the perikarya of the anterior horn cells. In anterior horn neurons occasional fragments of rough endoplasmic reticulum, lipofuscin and even nuclei were found among the neurofilaments, in addition to the other components. Rarely, some filamentous accumulations contained unusual features such as paracrystalline arrays, polyglucosan bodies and honeycomb-like structures. Linear densities, associated with ribosome-like particles, were found scattered within focal collections of randomly arranged neurofilaments in some perikarya of two cases. Occasional mitochondria with regularly arranged short protrusions on the outer membrane were observed in the myelinated axons in one case.

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Copyright © 1984 by the American Association of Neuropathologists

Topic:

• mitochondria
• amyotrophic lateral sclerosis
• anterior horn cells
• axon
• cell nucleus
• rough endoplasmic reticulum
• endoplasmic reticulum, smooth
• horns
• lipofuscin
• tissue membrane
• myelin sheath
• ribosomes
• spheroids, cellular
• spinal cord
• vesicle

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