Antibody-dependent Enhancement of Yellow Fever and Japanese Encephalitis Virus Neurovirulence (original) (raw)

Abstract

SUMMARY

Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.

Received: 10/10/1988
Accepted:06/03/1989
Published Online:01/06/1989

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/content/journal/jgv/10.1099/0022-1317-70-6-1605

1989-06-01

2024-10-23

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