Role of nutrients in the development of neonatal immune response (original) (raw)

Journal Article

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Susanna Cunningham-Rundles

Division of Hematology/Oncology, Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA.

S Cunningham-Rundles, Department of Pediatrics, Cornell University Weill Medical College, 1300 York Avenue, New York, NY 10021, USA. E-mail: scrundle@mail.med.cornell.edu, Phone: +1-212-746-3414, Fax: +1-212-746-8512.

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Division of Hematology/Oncology, Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA.

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Division of Hematology/Oncology, Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA.

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Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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Division of Neonatology, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA.

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Published:

01 November 2009

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Susanna Cunningham-Rundles, Hong Lin, Deborah Ho-Lin, Ann Dnistrian, Barrie R Cassileth, Jeffrey M Perlman, Role of nutrients in the development of neonatal immune response, Nutrition Reviews, Volume 67, Issue suppl_2, 1 November 2009, Pages S152–S163, https://doi.org/10.1111/j.1753-4887.2009.00236.x
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Abstract

Nutrients exert unique regulatory effects in the perinatal period that mold the developing immune system. The interactions of micronutrients and microbial and environmental antigens condition the post-birth maturation of the immune system, influencing reactions to allergens, fostering tolerance towards the emerging gastrointestinal flora and ingested antigens, and defining patterns of host defense against potential pathogens. The shared molecular structures that are present on microbes or certain plants, but not expressed by human cells, are recognized by neonatal innate immune receptors. Exposure to these activators in the environment through dietary intake in early life can modify the immune response to allergens and prime the adaptive immune response towards pathogens that express the corresponding molecular structures.

© 2009 International Life Sciences Institute

Topic:

• immune response
• diet
• allergens
• antigens
• immune system
• newborn
• micronutrients
• molecular structure
• plants
• pathogenic organism
• transcriptional activation
• nutrients
• host defense
• intestinal bacteria
• ingestion
• perinatal period
• mold
• microorganisms

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