Serum Immunoglobulin Concentrations in Patients Admitted to an Acute Psychiatric In-patient Service | The British Journal of Psychiatry | Cambridge Core (original) (raw)

Article contents

Summary

Serum immunoglobulins were quantified in 85 consecutively admitted patients from an acute-care psychiatric in-patient unit. The patients were diagnosed as: major depressive disorder, 53; chronic schizophrenia, 12; schizophreniform psychosis, 4; substance abuse disorder, 12; and miscellaneous other diagnoses, 4. A small sub-group of these patients, which included six with major depression, one with chronic schizophrenia, and one with a personality disorder, were found to have low IgM concentrations. Immunoglobulin levels were not associated with use of medication or length of illness prior to this hospital admission. This study provides further evidence for suppression of humoral immunity in some psychiatric patients (approximately 10%).

Type

Brief Reports

Copyright

Copyright © 1984 The Royal College of Psychiatrists

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References

Albrecht, P., Torrey, E. F., Boone, E., Hicks, J. & Daniel, N. (1980) Raised cytomegalovirus-antibody levels in cerebrospinal fluid of schizophrenic patients. Lancet 2, 769–72.Google Scholar

Amkraut, A., Solomon, G. F., Allansmith, M., McClellan, G. & Rappaport, M. (1973) Immunoglobulins and improvement in acute schizophrenic reactions. Archives of General Psychiatry, 28, 673–7.Google Scholar

Bartrop, R. W., Lazarus, L., Luckhurst, E. & Kiloh, L. G. (1977) Depressed lymphocyte function after bereavment. Lancet, i, 834–6.Google Scholar

DeLisi, L. E. & Wyatt, R. J. (1984) Neurochemical aspects of schizophrenia. In Handbood of Neurochemistry, Vol. 10, (ed. Lajtha, A.). .Google Scholar

DeLisi, L. E. Weinberger, D. R., Neckers, L. M., Potkin, S., Shiling, D. J. & Wyatt, R. J. (1981) Quantitive determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients. British Journal of Psychiatry, 139, 513–9.Google Scholar

Domino, E. F., Krause, R. R., Thiessen, M. M. & Batsakis, J. G. (1975) Blood protein fraction comparisons of normal and schizophrenic patients. Archives of General Psychiatry, 32, 717–21.Google Scholar

Endicott, J., Spitzer, R. L., Fleiss, J. L. & Cohen, J. (1976) The Global Assessment Scale: a procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33, 766–72.CrossRefGoogle Scholar

Evans, N. J. R., Baldwin, J. A. & Gath, D. (1974) The incidence of cancer among inpatients with affective disorders. British Journal of Psychiatry, 124, 518–25.Google Scholar

Hall, R. C. W., Gardner, E. R., Stickney, S. K., LeCann, A. F. & Popkin, M. K. (1980) Physical illness manifesting as psychiatric disease. Archives of General Psychiatry, 37, 989–95.Google Scholar

Hendrie, H. C., Paraskivas, F. & Varsamis, J. (1972) Gamma globulin levels in psychiatric patients. Canadian Psychiatric Association Journal, 17, 93–7.Google Scholar

Johnstone, E. C. & Whaley, K. (1975) Antinuclear antibodies in psychiatric illness: their relationship to diagnosis and drug treatment. British Medical Journal, 2, 724–5.Google Scholar

Kronfol, Z., Silva, J., Greden, J., Dembinski, S., Gardner, R. & Carroll, B. (1983) Impaired lymphocyte function in depressive illness. Life Science, 18, 241–7.Google Scholar

McGuffin, P. (1980) What have transplant antigens got to do with psychoses? British Journal of Psychiatry, 136, 510–2.Google Scholar

Pulkkinen, E. (1977) Immunoglobulins, psychopathology and prognosis in schizophrenia. Acta Psychiatrica Scandinavica, 56, 173–82.Google Scholar

Schleifer, S. J., Keller, S. E., Camerino, M., Thornton, J. C. & Stein, M. (1983) Suppression of Lymphocyte stimulation following bereavment. Journal of the American Medical Association, 250, 374–7.Google Scholar

Solomon, G. F., Allansmith, M., McClellan, B. & Amkraut, A. (1969) Immunoglobulins in psychiatric patients. Archives of General Psychiatry, 20, 272–7.Google Scholar

Strahilevitz, M. & Davis, S. D. (1970) Increased IgA in schizophrenic patients. Lancet, 2, 370.Google Scholar

Strahilevitz, M. Fleischman, J. B., Fischer, G. W., Harris, R. & Narasimhachari, N. (1976) Immunoglobulin levels in psychiatric patients. American Journal of Psychiatry, 133, 772–7.Google Scholar

Sugarman, A. A., Southern, D. L., Curran, J. F. (1982) A study of antibody levels in alcoholic depressive and schizophrenic patients. Annals of Allergy, 48, 166–71.Google Scholar

Torrey, E. F., Peterson, M. R., Brannon, W. L., Carpenter, W. T., Post, R. M. & Van Kammen, D. P. (1980) Immunoglobulins and viral antibodies in psychiatric patients. British Journal of Psychiatry, 132, 342–8.Google Scholar

Torrey, E. F. Yolken, R. H. & Winfrey, C. J. (1982) Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay. Science, 216, 892–4.Google Scholar

Zarrabi, M. H., Zucker, S., Miller, F., Derman, R. M., Romano, G. S., Hartnett, J. A. & Varma, A. O. (1979) Immunologie and coagulation disorders in chlorpromazine treated patients. Annals of Internal Medicine, 91, 194–9.Google Scholar