Computerised Tomography in Schizophrenia | The British Journal of Psychiatry | Cambridge Core (original) (raw)

Abstract

Findings on CT and demographical or clinical data in 80 patients with DSM–III schizophrenia and 45 medical controls were evaluated. Multiple-discriminant analysis showed that the enlargement of the third ventricle and frontal and parietal atrophy could significantly predict the diagnosis of schizophrenia. Widening of Sylvian fissures and parietal atrophy differentiated familial schizophrenics of both horizontal transmission (who had affected siblings) and vertical transmission (who had affected parents or/and offspring) from non-familial patients. Parietal atrophy and a history of birth complications differentiated horizontal from vertical transmission. The CT findings together with some clinical characteristics could differentiate the three subgroups classified by the hereditary form; thus each of these subgroup may belong to a different disease entity, of a different pathophysiology.

References

Alm, T., Lindstrom, L. H., Ost, L-G., et al (1984) Electrodermal non-responding in schizophrenia: relationships to attentional, clinical, biochemical, computed tomographical and genetic factors. International Journal of Psychophysiology, 1, 195–208.Google Scholar

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) . Washington, DC: APA.Google Scholar

Andreasen, N. C., Olsen, S. A., Dennert, J. W., et al (1982) Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms. American Journal of Psychiatry, 139, 292–302.Google Scholar

Boronow, J., Pickar, D., Ninan, P. T., et al (1985) Atrophy limited to the third ventricle in chronic schizophrenic patients. Archives of General Psychiatry, 42, 266–271.CrossRef Google Scholar

Buchsbaum, M. S., Mirsky, A. F., Delisi, L. E., et al (1984) The genain quadruplets: electrophysiological, positron emission, and x-ray tomographic studies. Psychiatry Research, 13, 95–108.Google Scholar

Campbell, R., Hays, P., Russell, D. B., et al (1979) CT scan variants and genetic heterogeneity in schizophrenia. American Journal of Psychiatry, 136, 722–723.Google Scholar

Crow, T. J. (1984) A re-evaluation of the viral hypothesis: is psychosis the result of retroviral integration at a site close to the cerebral dominance gene? British Journal of Psychiatry, 145, 234–253.Google Scholar

Delisi, L. E., Goldin, L. R., Hamovit, J. R., et al (1986) A family study of the association of increased ventricular size with schizophrenia. Archives of General Psychiatry, 43, 148–153.Google Scholar

Demeyer, M. K., Gilmor, R., Demeyer, W. E., et al (1984) Third ventricle size and ventricular/brain ratio in treatment-resistant psychiatric patients. Journal of Operational Psychiatry, 15, 2–8.Google Scholar

Dewan, M. J., Pandurangi, A. K., Lee, S. H., et al (1983) Central brain morphology in chronic schizophrenic patients: a controlled CT study. Biological Psychiatry, 18, 1133–1140.Google Scholar

Farmer, A., McGuffin, P., Jackson, R., et al (1985) Classifying schizophrenia. Lancet, i, 1333.Google Scholar

Gross, G., Huber, G. & Schuttler, R. (1982) Computerized tomography studies on schizophrenic diseases. Archive fur Psychiatrie und Nervenkrankheiten, 231, 519–526.Google Scholar

Jeste, D.V., Kleinman, J. E., Potkin, S. G., et al (1982) Ex uno multi: Subtyping the schizophrenic syndrome. Biological Psychiatry, 17, 199–222.Google Scholar PubMed

Johnstone, E. C., Crow, T. J., Frith, C. D., et al (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet, i, 924–926.Google Scholar

Kendler, K. S. & Hays, P. (1982) Familial and sporadic schizophrenia: a symptomatic, prognostic, and EEG comparison. American Journal of Psychiatry, 139, 1557–1562.Google Scholar

Kendler, K. S., Gruenbero, A. M. & Tsuano, M. T. (1985) Psychiatric illness in first-degree relatives of schizophrenic and surgical control patients. Archives of General Psychiatry, 42, 770–779.Google Scholar

Kraepelin, E. (1913) Psychiatrie. Achte vollstandig umgearbeitete Auflage. III. Band. Klinische Psychiatrie. II. Teil. Leipzig: Johann Ambrosius Barth.Google Scholar

Largen, J. W. Jr, Smith, R. C., Calderon, M., et al (1984) Abnormalities of brain structure and density in schizophrenia. Biological Psychiatry, 19, 991–1013.Google Scholar

Losonczy, M. F., Song, I. S., Mohs, R. C., et al (1986) Correlates of lateral ventricular size in chronic schizophrenia. I. Behavioral and treatment response measures. American Journal of Psychiatry, 143, 976–981.Google Scholar

Luchins, D. J., Lewine, R. R. J. & Meltzer, H. Y. (1984) Lateral ventricular size, psychopathology, and medication response in the psychoses. Biological Psychiatry, 19, 29–44.Google Scholar

Moriuchi, I. (1981) A study of schizophrenic brains by computerized tomography scans. Folia Psychiatrica et Neurologica Japonica, 35, 55–72.Google Scholar

Nasrallah, H. A., McCalley-Whitters, M. & Jacoby, C. G. (1982) Cortical atrophy in schizophrenia and mania: a comparative CT study. Journal of Clinical Psychiatry, 43, 439–441.Google Scholar

Nasrallah, H. A., Kuperman, S., Hamra, B. J., et al (1983a) Clinical differences between schizophrenic patients with and without large cerebral ventricles. Journal of Clinical Psychiatry, 44, 407–409.Google Scholar PubMed

Nasrallah, H. A., Kuperman, S., Jacoby, C. G., et al (1983b) Clinical correlates of sulcal widening in chronic schizophrenia. Psychiatry Research, 10, 237–242.Google Scholar

Nasrallah, H. A., Jacoby, C. G., Chapman, S., et al (1985) Third ventricular enlargement on CT scans in schizophrenia: association with cerebellar atrophy. Biological Psychiatry, 20, 443–450.Google Scholar

Okasha, A. & Madkour, O. (1982) Cortical and central atrophy in chronic schizophrenia. Acta Psychiatrica Scandinavica, 65, 29–34.Google Scholar

Oxenstierna, G., Bergstrand, G., Bjerkenstedt, L., et al (1984) Evidence of disturbed CSF circulation and brain atrophy in cases of schizophrenic psychosis. British Journal of Psychiatry, 144, 654–661.Google Scholar PubMed

Owens, D. G. C., Johnstone, E. C., Crow, T. J., et al (1985) Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychological Medicine, 15, 27–41.Google Scholar

Pandurangi, A. K., Dewan, M. J., Lee, S. H., et al (1984) The ventricular system in chronic schizophrenic patients. A controlled computed tomography study. British Journal of Psychiatry, 144, 172–176.Google Scholar

Pearlson, G. D., Garbacz, D. J., Moberg, P. J., et al (1985) Symptomatic, familial, perinatal, and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars. Journal of Nervous and Mental Disease, 173, 42–50.Google Scholar

Reveley, A. M., Reveley, M. A., Clifford, C. A., et al (1982) Cerebral ventricular size in twins discordant for schizophrenia. Lancet, i, 540–541.Google Scholar

Reveley, A. M., Reveley, M. A., Chitkara, B., et al (1984a) The genetic basis of cerebral venticular volume. Psychiatry Research, 13, 261–266.CrossRef Google Scholar

Reveley, A. M., Reveley, M. A. & Murray, R. M. (1984b) Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. British Journal of Psychiatry, 144, 89–93.Google Scholar

Reveley, A. M., Belleroche, J. D., Recordati, A., et al (1987) Increased CSF amino acids and ventricular enlargement in schizophrenia: a preliminary study. Biological Psychiatry, 22, 413–420.Google Scholar

Rieder, R. O., Donnelly, E. F., Herdt, J. R., et al (1979) Sulcal prominence in young chronic schizophrenic patients: CT scan findings associated with impairment on neuropsychological tests. Psychiatry Research, 1, 1–8.Google Scholar

Schneider, K. (1962) Klinische Psychopathologie. Stuttgart: Georg Thieme.Google Scholar

Schulz, S. C., Sinicrope, P., Kishore, P., et al (1983) Treatment response and ventricular brain enlargement in young schizophrenic patients. Psychopharmacology Bulletin, 19, 510–512.Google Scholar

Shima, S., Kanba, S., Masuda, Y., et al (1985) Normal ventricles in chronic schizophrenics. Acta Psychiatrica Scandinavica, 71, 25–29.Google Scholar

Smith, R. C. & Maser, J. (1983) Morphological and neuropsychological abnormalities as predictors of clinical response to psychotropic drugs. Psychopharmacology Bulletin, 19, 505–509.Google Scholar

Smith, R. C., Baumgartner, R., Ravichandran, G. K., et al (1985) Lateral ventricular enlargement and clinical response in schizophrenia. Psychiatry Research, 14, 241–253.Google Scholar

Synek, V. & Reuben, J. R. (1976) The ventricular-brain ratio using planimetric measurement of EMI scans. British Journal of Radiology, 49, 233–237.Google Scholar

Takahashi, R., Inaba, Y., Inanaga, K., et al (1981) CT scanning and the investigation of schizophrenia. In Biological Psychiatry 1981 (eds Perris, C., Struwe, G. & Jansson, B.). Amsterdam. Elsevier/North-Holland Biomedical Press.Google Scholar

Turner, S. W., Toone, B. & Brett-Jones, J. R. (1986) Computerized tomographic scan changes in early schizophrenia-preliminary findings. Psychological Medicine, 16, 219–225.Google Scholar

van Kammen, D. P., van Kammen, W. B., Mann, L. S., et al (1986) Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy. Archives of General Psychiatry, 43, 978–983.Google Scholar

Weinberger, D. R., Bigelow, L. B., Kleinman, J. E., et al (1980) Cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 37, 11–13.Google Scholar

Weinberger, D. R., DeLisi, L. E., Neophytides, A. N., et al (1981) Familial aspects of CT scan abnormalities in chronic schizophrenic patients. Psychiatry Research, 4, 65–71.Google Scholar

Williams, A. O., Reveley, M. A., Kolakowska, T., et al (1985) Schizophrenia with good and poor outcome. II: Cerebral ventricular size and its clinical significance. British Journal of Psychiatry, 146, 229–246.Google Scholar