Carbohydrate Coingestion Delays Dietary Protein Digestion and Absorption but Does Not Modulate Postprandial Muscle Protein Accretion (original) (raw)

Journal Article

,

1Top Institute Food and Nutrition (S.H.M.G., N.A.B., H.M.H., L.J.C.v.L.), 6709 PA Wageningen, The Netherlands;

2Department of Human Movement Sciences (S.H.M.G., N.A.B., H.M.H., B.B.G., L.J.C.v.L.),6200 MD Maastricht, The Netherlands

Search for other works by this author on:

,

1Top Institute Food and Nutrition (S.H.M.G., N.A.B., H.M.H., L.J.C.v.L.), 6709 PA Wageningen, The Netherlands;

2Department of Human Movement Sciences (S.H.M.G., N.A.B., H.M.H., B.B.G., L.J.C.v.L.),6200 MD Maastricht, The Netherlands

Search for other works by this author on:

,

1Top Institute Food and Nutrition (S.H.M.G., N.A.B., H.M.H., L.J.C.v.L.), 6709 PA Wageningen, The Netherlands;

2Department of Human Movement Sciences (S.H.M.G., N.A.B., H.M.H., B.B.G., L.J.C.v.L.),6200 MD Maastricht, The Netherlands

Search for other works by this author on:

,

3NUTRIM School for Nutrition, Toxicology, and Metabolism, and Department of Human Biology (A.P.G.), NUTRIM, Maastricht University Medical Centre+, 6200 MD Maastricht, The Netherlands

Search for other works by this author on:

,

2Department of Human Movement Sciences (S.H.M.G., N.A.B., H.M.H., B.B.G., L.J.C.v.L.),6200 MD Maastricht, The Netherlands

Search for other works by this author on:

1Top Institute Food and Nutrition (S.H.M.G., N.A.B., H.M.H., L.J.C.v.L.), 6709 PA Wageningen, The Netherlands;

2Department of Human Movement Sciences (S.H.M.G., N.A.B., H.M.H., B.B.G., L.J.C.v.L.),6200 MD Maastricht, The Netherlands

*Address all correspondence and requests for reprints to: Professor L. J. C. van Loon, PhD, Department of Human Movement Sciences, Maastricht University Medical Centre+, PO Box 616, 6200 MD Maastricht, The Netherlands.

Search for other works by this author on:

Received:

01 November 2013

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Stefan H. M. Gorissen, Nicholas A. Burd, Henrike M. Hamer, Annemie P. Gijsen, Bart B. Groen, Luc J. C. van Loon, Carbohydrate Coingestion Delays Dietary Protein Digestion and Absorption but Does Not Modulate Postprandial Muscle Protein Accretion, The Journal of Clinical Endocrinology & Metabolism, Volume 99, Issue 6, 1 June 2014, Pages 2250–2258, https://doi.org/10.1210/jc.2013-3970
Close

Navbar Search Filter Mobile Enter search term Search

Background:

Dietary protein digestion and absorption is an important factor modulating muscle protein accretion. However, there are few data available on the effects of coingesting other macronutrients with protein on digestion and absorption kinetics and the subsequent muscle protein synthetic response.

Objective:

The objective of the study was to determine the impact of carbohydrate coingestion with protein on dietary protein digestion and absorption and muscle protein accretion in healthy young and older men.

Design:

Twenty-four healthy young (aged 21± 1 y, body mass index 21.8 ±0.5 kg/m2) and 25 older (aged 75 ± 1 y, body mass index 25.4 ± 0.6 kg/m2) men received a primed continuous L-[ring-2H5]-phenylalanine and L-[ring-3,5-2H2]-tyrosine infusion and ingested 20 g intrinsically L-[1-13C]-phenylalanine-labeled protein with (Pro+CHO) or without (Pro) 60 g carbohydrate. Plasma samples and muscle biopsies were collected in a postabsorptive and postprandial state.

Results:

Carbohydrate coingestion delayed the appearance of exogenous phenylalanine in the circulation (P = .001). Dietary protein-derived phenylalanine availability over the 5-hour postprandial period was lower in the older (62 ± 2%) when compared with the young subjects (74 ± 2%; P = .007), with no differences between conditions (P = .20). Carbohydrate coingestion did not modulate postprandial muscle protein synthesis rates (0.035 ± 0.003 vs 0.043 ± 0.004 and 0.033 ± 0.002 vs 0.035 ± 0.003%/h after Pro vs Pro+CHO in the young and older group, respectively). In accordance, no differences in muscle protein-bound L-[1-13C]-phenylalanine enrichments were observed between conditions (0.020 ± 0.002 vs 0.020 ± 0.002 and 0.019 ± 0.003 vs 0.022 ± 0.004 mole percent excess after Pro vs Pro+CHO in the young and older subjects, respectively).

Conclusion:

Carbohydrate coingestion with protein delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion in healthy young or older men.

Copyright © 2014 by the Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Carbohydrate Coingestion Delays Dietary Protein Digestion and Absorption but Does Not Modulate Postprandial Muscle Protein Accretion - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 6,945

5,442 Pageviews

1,503 PDF Downloads

Since 2/1/2017

Citations

109 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic