Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques (original) (raw)
Obesity Studies| November 01 2005
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
2Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
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1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
2Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
2Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
2Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
2Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
Search for other works by this author on:
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
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Address correspondence and reprint requests to Michael Cowley, PhD, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Ave., Beaverton, OR 97006. E-mail: [email protected]
Diabetes 2005;54(11):3198–3204
Citation
Frank H. Koegler, Pablo J. Enriori, Sonja K. Billes, Diana L. Takahashi, Meghan S. Martin, Randall L. Clark, Anne E. Evans, Kevin L. Grove, Judy L. Cameron, Michael A. Cowley; Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques. _Diabetes 1 November 2005; 54 (11): 3198–3204. https://doi.org/10.2337/diabetes.54.11.3198
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Peptide YY(3–36) [PYY(3–36)] is a hormone that is released after meal ingestion that is currently being investigated for the treatment of obesity; however, there are conflicting reports of the effects of PYY(3–36) on energy balance in rodent models. To shed light on this controversy, we studied the effect of PYY(3–36) on food intake and body weight in a nonhuman primate. Intravenous PYY(3–36) infusions before a morning meal transiently suppressed the rate of food intake but did not suppress the evening meal or 24-h intake. Twice-daily or continuous intravenous PYY(3–36) infusions to supraphysiological levels (levels that exceeded normal physiological levels) again suppressed the rate of feeding for the morning but not the evening meal. Twice-daily intravenous PYY(3–36) infusions for 2 weeks significantly decreased body weight in all test animals (average weight loss 1.9%) without changing insulin response to glucose infusion. These results show that endogenous PYY(3–36) may alter morning but not evening meal intake, and supraphysiological doses are required for effective suppression of food intake.
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