Simrita Sidhu | University of Edinburgh (original) (raw)

Papers by Simrita Sidhu

Research paper thumbnail of Estimating the burden of neural tube defects in low– and middle–income countries

Journal of Global Health, 2014

Estimating the burden of neural tube defects in low-and middle-income countries Background To pro... more Estimating the burden of neural tube defects in low-and middle-income countries Background To provide an estimate for the burden of neural tube defects (NTD) in low-and middle-income countries (LMIC) and explore potential public health policies that may be implemented. Although effective interventions are available to prevent NTD, there is still considerable childhood morbidity and mortality present in LMIC. Methods A search of Medline, EMBASE, Global Health Library and PubMed identified 37 relevant studies that provided estimates of the burden of NTD in LMIC. Information on burden of total NTD and specific NTD types was separated according to the denominator into two groups: (i) estimates based on the number of live births only; and (ii) live births, stillbirths and terminations. The data was then extracted and analysed. Results The search retrieved NTD burden from 18 countries in 6 WHO regions. The overall burden calculated using the median from studies based on livebirths was 1.67/1000 (IQR = 0.98-3.49) for total NTD burden, 1.13/1000 (IQR = 0.75-1.73) for spina bifida, 0.25/1000 (IQR = 0.08-1.07) for anencephaly and 0.15/1000 (IQR = 0.08-0.23) for encephalocele. Corresponding estimates based on all pregnancies resulting in live births, still births and terminations were 2.55/1000 (IQR = 1.56-3.91) for total NTD burden, 1.04/1000 (IQR = 0.67-2.48) for spina bifida, 1.03/1000 (IQR = 0.67-1.60) for anencephaly and 0.21 (IQR = 0.16-0.28) for encephalocele. This translates into about 190 000 neonates who are born each year with NTD in LMIC.

Research paper thumbnail of Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis

Journal of global health, 2015

Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It... more Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high-income countries, but little is known about the burden of this disease in low- and middle-income countries (LMIC). The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre-defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition. Meta-estimates of regional RA prevalence rates for countries of low or middle income were 0.40% (95% CI: 0.23-0.57%) for Southeast Asian, 0.37% (95% CI: 0.23-0.51%) for Eastern Mediterranean, 0.62% (95% CI:...

Research paper thumbnail of Urbanization and prevalence of type 2 diabetes in Southern Asia: A systematic analysis

Journal of Global Health, 2014

Diabetes mellitus is one of the diseases considered to be the main constituents of the global non... more Diabetes mellitus is one of the diseases considered to be the main constituents of the global non-communicable disease (NCD) pandemic. Despite the large impact that NCDs are predicted to have, particularly in developing countries, estimates of disease burden are sparse and inconsistent. This systematic review transparently estimates prevalence of type 2 diabetes mellitus in Southern Asia, its association with urbanization and provides insight into the policy challenges facing the region. The databases Medline and PubMed were searched for population-based studies providing estimates of diabetes prevalence in the Southern Asia region. Studies using WHO diagnostic criteria of fasting plasma glucose (FPG) ≥7.0mmol/L and/or 2h-plasma glucose (2hPG) ≥11.1mmol/L were included. Data from eligible studies was extracted into bubble graphs, and trend lines were applied to UNPD figures to estimate age-specific prevalence in the regional population. Estimates specific to sex, area of residency, and diagnostic method were compared and trends analysed. A total of 151 age-specific prevalence estimates were extracted from 39 studies. Diabetes prevalence was estimated to be 7.47% for 2005 and 7.60% for 2010. Prevalence was strongly associated with increased age, male gender and urban residency (P < 0.001). Diabetes prevalence in Southern Asia is high and predicted to increase in the future as life expectancy rises and the region continues to urbanise. Countries in this region need to improve NCD surveillance and monitoring so policies can be informed with the best evidence. Programs for prevention need to be put in place, and health system capacity and access needs to be assessed and increased to deal with the predicted rise in NCD prevalence.

Research paper thumbnail of Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis

Journal of global health, 2015

Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It... more Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high-income countries, but little is known about the burden of this disease in low- and middle-income countries (LMIC). The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre-defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition. Meta-estimates of regional RA prevalence rates for countries of low or middle income were 0.40% (95% CI: 0.23-0.57%) for Southeast Asian, 0.37% (95% CI: 0.23-0.51%) for Eastern Mediterranean, 0.62% (95% CI:...

Research paper thumbnail of Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis

Journal of global health, 2015

Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It... more Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high-income countries, but little is known about the burden of this disease in low- and middle-income countries (LMIC). The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre-defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition. Meta-estimates of regional RA prevalence rates for countries of low or middle income were 0.40% (95% CI: 0.23-0.57%) for Southeast Asian, 0.37% (95% CI: 0.23-0.51%) for Eastern Mediterranean, 0.62% (95% CI:...

Research paper thumbnail of Estimating the burden of neural tube defects in low– and middle–income countries

Journal of Global Health, 2014

To provide an estimate for the burden of neural tube defects (NTD) in low- and middle-income coun... more To provide an estimate for the burden of neural tube defects (NTD) in low- and middle-income countries (LMIC) and explore potential public health policies that may be implemented. Although effective interventions are available to prevent NTD, there is still considerable childhood morbidity and mortality present in LMIC. A search of Medline, EMBASE, Global Health Library and PubMed identified 37 relevant studies that provided estimates of the burden of NTD in LMIC. Information on burden of total NTD and specific NTD types was separated according to the denominator into two groups: (i) estimates based on the number of live births only; and (ii) live births, stillbirths and terminations. The data was then extracted and analysed. The search retrieved NTD burden from 18 countries in 6 WHO regions. The overall burden calculated using the median from studies based on livebirths was 1.67/1000 (IQR = 0.98-3.49) for total NTD burden, 1.13/1000 (IQR = 0.75-1.73) for spina bifida, 0.25/1000 (IQR = 0.08-1.07) for anencephaly and 0.15/1000 (IQR = 0.08-0.23) for encephalocele. Corresponding estimates based on all pregnancies resulting in live births, still births and terminations were 2.55/1000 (IQR = 1.56-3.91) for total NTD burden, 1.04/1000 (IQR = 0.67-2.48) for spina bifida, 1.03/1000 (IQR = 0.67-1.60) for anencephaly and 0.21 (IQR = 0.16-0.28) for encephalocele. This translates into about 190 000neonates who are born each year with NTD in LMIC. Limited available data on NTD in LMIC indicates the need for additional research that would improve the estimated burden of NTD and recommend suitable aid policies through maternal education on folic acid supplementation or food fortification.

Research paper thumbnail of Estimating the burden of neural tube defects in low– and middle–income countries

Journal of Global Health, 2014

Estimating the burden of neural tube defects in low-and middle-income countries Background To pro... more Estimating the burden of neural tube defects in low-and middle-income countries Background To provide an estimate for the burden of neural tube defects (NTD) in low-and middle-income countries (LMIC) and explore potential public health policies that may be implemented. Although effective interventions are available to prevent NTD, there is still considerable childhood morbidity and mortality present in LMIC. Methods A search of Medline, EMBASE, Global Health Library and PubMed identified 37 relevant studies that provided estimates of the burden of NTD in LMIC. Information on burden of total NTD and specific NTD types was separated according to the denominator into two groups: (i) estimates based on the number of live births only; and (ii) live births, stillbirths and terminations. The data was then extracted and analysed. Results The search retrieved NTD burden from 18 countries in 6 WHO regions. The overall burden calculated using the median from studies based on livebirths was 1.67/1000 (IQR = 0.98-3.49) for total NTD burden, 1.13/1000 (IQR = 0.75-1.73) for spina bifida, 0.25/1000 (IQR = 0.08-1.07) for anencephaly and 0.15/1000 (IQR = 0.08-0.23) for encephalocele. Corresponding estimates based on all pregnancies resulting in live births, still births and terminations were 2.55/1000 (IQR = 1.56-3.91) for total NTD burden, 1.04/1000 (IQR = 0.67-2.48) for spina bifida, 1.03/1000 (IQR = 0.67-1.60) for anencephaly and 0.21 (IQR = 0.16-0.28) for encephalocele. This translates into about 190 000 neonates who are born each year with NTD in LMIC.

Research paper thumbnail of Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis

Journal of global health, 2015

Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It... more Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high-income countries, but little is known about the burden of this disease in low- and middle-income countries (LMIC). The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre-defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition. Meta-estimates of regional RA prevalence rates for countries of low or middle income were 0.40% (95% CI: 0.23-0.57%) for Southeast Asian, 0.37% (95% CI: 0.23-0.51%) for Eastern Mediterranean, 0.62% (95% CI:...

Research paper thumbnail of Urbanization and prevalence of type 2 diabetes in Southern Asia: A systematic analysis

Journal of Global Health, 2014

Diabetes mellitus is one of the diseases considered to be the main constituents of the global non... more Diabetes mellitus is one of the diseases considered to be the main constituents of the global non-communicable disease (NCD) pandemic. Despite the large impact that NCDs are predicted to have, particularly in developing countries, estimates of disease burden are sparse and inconsistent. This systematic review transparently estimates prevalence of type 2 diabetes mellitus in Southern Asia, its association with urbanization and provides insight into the policy challenges facing the region. The databases Medline and PubMed were searched for population-based studies providing estimates of diabetes prevalence in the Southern Asia region. Studies using WHO diagnostic criteria of fasting plasma glucose (FPG) ≥7.0mmol/L and/or 2h-plasma glucose (2hPG) ≥11.1mmol/L were included. Data from eligible studies was extracted into bubble graphs, and trend lines were applied to UNPD figures to estimate age-specific prevalence in the regional population. Estimates specific to sex, area of residency, and diagnostic method were compared and trends analysed. A total of 151 age-specific prevalence estimates were extracted from 39 studies. Diabetes prevalence was estimated to be 7.47% for 2005 and 7.60% for 2010. Prevalence was strongly associated with increased age, male gender and urban residency (P < 0.001). Diabetes prevalence in Southern Asia is high and predicted to increase in the future as life expectancy rises and the region continues to urbanise. Countries in this region need to improve NCD surveillance and monitoring so policies can be informed with the best evidence. Programs for prevention need to be put in place, and health system capacity and access needs to be assessed and increased to deal with the predicted rise in NCD prevalence.

Research paper thumbnail of Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis

Journal of global health, 2015

Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It... more Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high-income countries, but little is known about the burden of this disease in low- and middle-income countries (LMIC). The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre-defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition. Meta-estimates of regional RA prevalence rates for countries of low or middle income were 0.40% (95% CI: 0.23-0.57%) for Southeast Asian, 0.37% (95% CI: 0.23-0.51%) for Eastern Mediterranean, 0.62% (95% CI:...

Research paper thumbnail of Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis

Journal of global health, 2015

Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It... more Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high-income countries, but little is known about the burden of this disease in low- and middle-income countries (LMIC). The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre-defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition. Meta-estimates of regional RA prevalence rates for countries of low or middle income were 0.40% (95% CI: 0.23-0.57%) for Southeast Asian, 0.37% (95% CI: 0.23-0.51%) for Eastern Mediterranean, 0.62% (95% CI:...

Research paper thumbnail of Estimating the burden of neural tube defects in low– and middle–income countries

Journal of Global Health, 2014

To provide an estimate for the burden of neural tube defects (NTD) in low- and middle-income coun... more To provide an estimate for the burden of neural tube defects (NTD) in low- and middle-income countries (LMIC) and explore potential public health policies that may be implemented. Although effective interventions are available to prevent NTD, there is still considerable childhood morbidity and mortality present in LMIC. A search of Medline, EMBASE, Global Health Library and PubMed identified 37 relevant studies that provided estimates of the burden of NTD in LMIC. Information on burden of total NTD and specific NTD types was separated according to the denominator into two groups: (i) estimates based on the number of live births only; and (ii) live births, stillbirths and terminations. The data was then extracted and analysed. The search retrieved NTD burden from 18 countries in 6 WHO regions. The overall burden calculated using the median from studies based on livebirths was 1.67/1000 (IQR = 0.98-3.49) for total NTD burden, 1.13/1000 (IQR = 0.75-1.73) for spina bifida, 0.25/1000 (IQR = 0.08-1.07) for anencephaly and 0.15/1000 (IQR = 0.08-0.23) for encephalocele. Corresponding estimates based on all pregnancies resulting in live births, still births and terminations were 2.55/1000 (IQR = 1.56-3.91) for total NTD burden, 1.04/1000 (IQR = 0.67-2.48) for spina bifida, 1.03/1000 (IQR = 0.67-1.60) for anencephaly and 0.21 (IQR = 0.16-0.28) for encephalocele. This translates into about 190 000neonates who are born each year with NTD in LMIC. Limited available data on NTD in LMIC indicates the need for additional research that would improve the estimated burden of NTD and recommend suitable aid policies through maternal education on folic acid supplementation or food fortification.