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Clinical and Experimental Immunology, Jan 1, 2008
CFA is an inflammatory condition of the lungs resulting in scarring, pulmonary failure and death.... more CFA is an inflammatory condition of the lungs resulting in scarring, pulmonary failure and death. The etiology of the disease is unknown, but the pathogenesis is believed to involve a persistent immunological reaction to unidentified antigen in the lung resulting in tissue damage. Recent advances in our understanding of the immune system have shown that different patterns of stimulatory cytokines are produced at sites of inflammation by a range of cell types. Patterns of cytokine production by inflammatory cells are recognized to be associated with different patterns of immunological response, and these have been described as type 1 (or Th1-like) and type 2 (or Th2-like) on this basis. We have studied cytokine expression in the intestinal inflammatory cell infiltrate in lung tissue from patients with CFA using mRNA in situ hybridization and immunohistochemistry. Our results show that while there is evidence for both a type 1 (characterized by interferon-gamma (IFN-γ)) and type 2 (characterized by IL-4 and IL-5) response present in CFA, the type 2 (or Th2) pattern of cytokines appears to predominate. This would be consistent with a possible role for the humoral immune response in the pathogenesis of this condition. In addition, recent evidence suggests that IL-4 and IFN-γ may be important regulatory factors for pulmonary fibroblasts. The relative paucity of IFN-γ may contribute to the excessive fibroblast activation, deposition of collagen and scar formation that occurs in CFA.
In this work, we focus our interest on blind source camera identification problem by extending ou... more In this work, we focus our interest on blind source camera identification problem by extending our results in the direction of M. Kharrazi et al. (2004). The interpolation in the color surface of an image due to the use of a color filter array (CFA) forms the basis of the paper. We propose to identify the source camera of an image based on traces of the proprietary interpolation algorithm deployed by a digital camera. For this purpose, a set of image characteristics are defined and then used in conjunction with a support vector machine based multi-class classifier to determine the originating digital camera. We also provide initial results on identifying source among two and three digital cameras.
What do eBay, Amazon.com and CNN.com have in common? They're all applications that integ... more What do eBay, Amazon.com and CNN.com have in common? They're all applications that integrate large databases with the Web. The popularity (and power) of these applications stems from their accessibility and usability: thousands of users can access the same data at the same time ...
Clinical and Experimental Immunology, Jan 1, 2008
CFA is an inflammatory condition of the lungs resulting in scarring, pulmonary failure and death.... more CFA is an inflammatory condition of the lungs resulting in scarring, pulmonary failure and death. The etiology of the disease is unknown, but the pathogenesis is believed to involve a persistent immunological reaction to unidentified antigen in the lung resulting in tissue damage. Recent advances in our understanding of the immune system have shown that different patterns of stimulatory cytokines are produced at sites of inflammation by a range of cell types. Patterns of cytokine production by inflammatory cells are recognized to be associated with different patterns of immunological response, and these have been described as type 1 (or Th1-like) and type 2 (or Th2-like) on this basis. We have studied cytokine expression in the intestinal inflammatory cell infiltrate in lung tissue from patients with CFA using mRNA in situ hybridization and immunohistochemistry. Our results show that while there is evidence for both a type 1 (characterized by interferon-gamma (IFN-γ)) and type 2 (characterized by IL-4 and IL-5) response present in CFA, the type 2 (or Th2) pattern of cytokines appears to predominate. This would be consistent with a possible role for the humoral immune response in the pathogenesis of this condition. In addition, recent evidence suggests that IL-4 and IFN-γ may be important regulatory factors for pulmonary fibroblasts. The relative paucity of IFN-γ may contribute to the excessive fibroblast activation, deposition of collagen and scar formation that occurs in CFA.
In this work, we focus our interest on blind source camera identification problem by extending ou... more In this work, we focus our interest on blind source camera identification problem by extending our results in the direction of M. Kharrazi et al. (2004). The interpolation in the color surface of an image due to the use of a color filter array (CFA) forms the basis of the paper. We propose to identify the source camera of an image based on traces of the proprietary interpolation algorithm deployed by a digital camera. For this purpose, a set of image characteristics are defined and then used in conjunction with a support vector machine based multi-class classifier to determine the originating digital camera. We also provide initial results on identifying source among two and three digital cameras.
What do eBay, Amazon.com and CNN.com have in common? They're all applications that integ... more What do eBay, Amazon.com and CNN.com have in common? They're all applications that integrate large databases with the Web. The popularity (and power) of these applications stems from their accessibility and usability: thousands of users can access the same data at the same time ...