Bülent Kayahan | Ege University (original) (raw)
Papers by Bülent Kayahan
PubMed, 2005
Schizophrenia and obsesive compulsive disorder (OCD) are among the oldest described psychiatric d... more Schizophrenia and obsesive compulsive disorder (OCD) are among the oldest described psychiatric disorders. Although they appear to be two distinct psychiatric disorders, early literature about the existence of obsessive-compulsive symptoms in schizophrenia dates back to the 1920's. The findings that atypical antipsychotics exacerbate obsessive-compulsive symptoms among schizophrenic patients and the emergence of a possible biological relation between the two diseases increased interest in this subject. Until the 1990's information about the aetiology of obsessive-compulsive symptoms which are observed in about 60% of schizophrenic patients, was insufficient. Recently there has been progress in explaining the structural and functional abnormalities in both OCD and schizophrenia. Knowledge of the cortico-subcortical circuits might explain the co-incidence of symptomatology in the two disorders. It is shown that there is prefrontal cortex dysfunction in both disorders but the bases of dysfunctions are distinct from each other. These dyfunctions derive from two different neuro-anatomical systems partially connected with each other and with different neuro-anatomical connections. It is suggested that dorsolateral prefrontal cortex (DLPC) dysfunction occurs in schizophrenia and ventro-medial prefrontal cortex dysfunction (VMPC) in OCD. In this review, the incidence of obsessive-compulsive symptoms in schizophrenia, their effect on the disorder, the features of the schizo-obsessive patient group and the mechanism of how atypical antipsychotics exacerbate obsessive compulsive symptoms are discussed. Thus, we aimed to highlight the neurobiologic heterogeneity and phenomenology of schizophrenic disorder.
Psychiatry and Clinical Neurosciences, Jun 1, 2005
Obsessive-compulsive symptoms (OCS) have been observed in a substantial proportion of schizophren... more Obsessive-compulsive symptoms (OCS) have been observed in a substantial proportion of schizophrenic patients. In this study, the rate of occurrence of OCS and obsessive-compulsive disorder (OCD) in schizophrenic patients, and also the interrelationship between OCS and schizophrenic symptoms and depressive symptoms were assessed. A total of 100 subjects with a diagnosis of schizophrenia from the 4th edition of the Diagnostic and Statistical Manual (DSM-IV) were evaluated by the structured and clinical interview for axis-1 DSM-IV disorders-patient edition (SCID-P), the Positive and Negative Syndrome Scale (PANSS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and the Calgary Depression Rating Scale for Schizophrenia. The prevalance of OCS in individuals meeting criteria for schizophrenia was 64%. A total of 30 of these patients (Y-BOCS total score > or =7) also met the DSM-IV criteria for OCD. The total score on Y-BOCS was significantly correlated with total score on PANSS, Positive-PANSS score, General-PANSS score and total score on Calgary Depression Rating Scale for Schizophrenia. OCS and OCD relatively frequent in schizophrenic patients and OCS are significantly correlated with the severity of psychosis, positive symptoms, and depressive symptoms in schizophrenic patients. These findings provide further evidence for the importance of OCS in schizophrenia.
Neurology Psychiatry and Brain Research, Aug 1, 2013
Abstract Introduction Schizophrenia is a complex neuropsychiatric disorder with deficits of multi... more Abstract Introduction Schizophrenia is a complex neuropsychiatric disorder with deficits of multiple domains of cognitive functions, volition and emotions. Family and twin studies have provided cumulative evidence for the genetic basis of schizophrenia. The aetiolgy of this disease involves the interplay of multifactiorial inheritance operating on brain maturational processes and polygenic inheritance with some genes showing susceptibility at many genomic locations such as 22q and 11q. The catechol-O-methyltransferase (COMT-22q11) is an extensively studied candidate gene for schizophrenia. COMT acts as an enzymatic detoxicating barrier between the blood and other tissues regulating the amounts of active dopamine and norepinephrine in various parts of the brain and therefore to be associated with schizophrenia. The presence of a common functional single nucleotide polymorphism (SNP) in exon 4 [Guanine (G) Adenine (A); Val108/158Met], alters the enzymatic activity with a trimodal distribution of high-HH, intermediate-HL and low-LL activity alleles which appear to have association with schizophrenia. Brain-derived neurotrophic factor (BDNF-11q13) is a member of the nerve growth factor family working as a molecular regulator of neuronal development and plasticity. Molecules that are critical in the development and survival of neurons such as BDNF play a significant role in the neuropathology of schizophrenia. While upregulation of BDNF increases the neuronal cell size and synaptic plasticity, a functional polymorphism at codon 66 [G→A; Val66Met] down regulates this process and induces schizophrenia. Objective In the present study, our aim was to investigate the differences in allele frequencies between schizophrenic patients [n = 97 (51 men, 46 women)] and control group [n = 376 (228 men, 148 women)] subjects. Results When the control and schizophrenia groups were compared for BDNFVal66Met polymorphism, we did not find a significant difference between the study groups either for genotype (χ2 = 3.370447, p > 0.05) or Val/Met haplotype analysis (χ2 = 2.840264, p > 0.05). When a comparison was revealed for COMT-Val108/158Met polymorphism, no significant difference was detected among schizophrenia and control groups for genotype (χ2 = 0.373330, p > 0.05) and Val/Met haplotype analysis (χ2 = 0.339073, p > 0.05). When the control and study groups were compared for BDNFVal66Met–COMTVal108/158Met polymorphisms compound genotype and haplotype analyses, there was no significant difference between the two groups (χ2 = 11.015; p > 0.05 and χ2 = 3.191; p > 0.05), respectively. Conclusion Our results indicate that there is no association between schizophrenia and BDNF–COMT polymorphisms and haplotypes analysis. We also did not find an association between schizophrenia and BDNF–COMT compound genotype and haplotype analyses. Although our study is unique in Turkey as combining BDNF and COMT compound genotype–haplotype analyses, for a generalization of Turkish schizophrenia patient's susceptibility to schizophrenia; we need further studies with an enlarged cohort.
Anadolu psikiyatri dergisi, 2013
Objective: The neurotrophine 'brain derived neurotrophic factor' (BDNF) which is expressed in the... more Objective: The neurotrophine 'brain derived neurotrophic factor' (BDNF) which is expressed in the brain is responsible for neuronal survive and functioning also plays a role in pathophysiology of alcohol dependence that show multifactorial and polygenic heredity. In the current study, we aimed to define the frequency of the functional Val66Met [G196A; (rs6265)] polymorphism of BDNF gene for Turkish male and female alcohol dependent cases and also to identify whether this polymorphism had any effect upon tendency to alcoholism. Methods: Genotype distribution and allele frequency of BDNF Val66Met polymorphism was identified via PCR-RFLP (Polymerase
Psychiatry and Clinical Psychopharmacology, 2017
Melatonin is an indoleamine often used in children and adolescents. Melatonin is considered to be... more Melatonin is an indoleamine often used in children and adolescents. Melatonin is considered to be an effective clinical management for dyssomnias, sleep disorders present in children with attention-deficit hyperactivity, autism spectrum disorders, developmental delays. Quickacting capsules, controlled-release (CR) capsules, sublingual tablets and liquid forms are available. Melatonin is generally very well-tolerated in children and adolescents. The pharmacology, therapeutic applications, and side effects of melatonin are discussed.
Anadolu Psikiyatri …, 2006
With the development of novel drugs, we have seen a significant improvement in the treatment of s... more With the development of novel drugs, we have seen a significant improvement in the treatment of schizophrenia and have been able to control negative symptoms and extropyramidal side effects. Unfortunately, most of the novel antipsychotics have metabolic side effects, ...
European Psychiatry, Mar 1, 2016
Introduction Social environment may lead to emergence and persistence of psychotic experiences. O... more Introduction Social environment may lead to emergence and persistence of psychotic experiences. Objectives Testing differential impact of social environments on emergence and persistence of subclinical psychotic experiences. Aims To assess different social environments that predicts emergence and persistence of subclinical psychotic experiences in a 6-year follow-up of a representative general population sample. Methods A longitudinal prospective cohort study (the TurkSch - The Izmir Mental Health Survey for Gene-Environment in Psychoses) was conducted with a general population sample ( n =4011) from Izmir-Turkey, who were 15-64 years of age at baseline. Sociodemographic factors, social environmental exposures (deprivation and social capital of neighbourhoods, and familial dysfunction and relationships), and measures of psychopathology (subclinical psychotic experiences) were assessed across two waves (T 1 -2008 and T 2 -2014; n =2192) using the Composite International Diagnostic Interview. Results Measures of wider social environment at T 1 (high social control and social deprivation within neighbourhoods) was associated with emergence (OR=1.6; 95% CI=0.6-2.4) and persistence (OR=1.8; 95% CI=0.6-2.4) of psychotic experiences at T 2 . Also, measures of familial dysfunction and relationships were associated with emergence (OR=2.1; 95% CI=1.2-3.3) and persistence (OR=3.3; 95% CI=1.4-6.7) at T 2 . The associations between wider social environment and psychotic experiences were not significant after adjusting for measures of family dysfunction relationship. Conclusions The association between wider social environment and psychosis may be partially a result of dysfunctional relationships within the narrow environment including family. Current and past difficult family relationships may be an important contributing factor.
Comprehensive psychiatry, 2012
Although obsessive-compulsive symptoms are not considered primary features, they are prevalent, i... more Although obsessive-compulsive symptoms are not considered primary features, they are prevalent, independent of psychosis, and substantially modify clinical characteristics, course, treatment and prognosis of schizophrenia. The authors highlight the clinical significance of obsessive-compulsive symptoms in schizophrenia, provide diagnostic criteria for "schizo-obsessive" patients and address future directions for research.
European Psychiatry, 2016
Introduction Subthreshold depression is prevalent in general population and is associated with po... more Introduction Subthreshold depression is prevalent in general population and is associated with poorer quality of life, higher health care use and increased risk of mental disorders mainly depression. Objectives Testing predictive impact of subthreshold depression on emergence and persistence of subclinical psychotic experiences. Aims To assess association between subthreshold depression and persistence of subclinical psychotic experiences in a 6-year follow-up of a representative general population sample. Methods A longitudinal prospective cohort study (the TurkSch The Izmir Mental Health Survey for Gene–Environment in Psychoses) was conducted with a general population sample ( n =4011) from Izmir, Turkey, who were 15–64 years of age at baseline. Sociodemographic factors, subthreshold depression (based on responses to systematic screening questions of the relevant questions with having less than five symptoms or having symptoms less than two weeks or having non-interfering impairme...
European Neuropsychopharmacology, 2017
23rd Annual World Congress of Psychiatric Genetics (WCPG) -- OCT 16-20, 2015 -- Toronto, CANADAWO... more 23rd Annual World Congress of Psychiatric Genetics (WCPG) -- OCT 16-20, 2015 -- Toronto, CANADAWOS: 00041384380018
Saudi Journal of Ophthalmology, 2018
A 27-year-old male with a repetitive behavior of eyeball pressing for six months presented with d... more A 27-year-old male with a repetitive behavior of eyeball pressing for six months presented with decreasing visual acuity for three months. Upon arrival his best corrected visual acuity was 0.2 on the right and 0.6 on the left eyes. Scheimpflug camera system demonstrated grade 4 and grade 2 keratoconus, respectively. Psychiatric consultation revealed Tourette syndrome and treatment was started. Despite psychiatric treatment, acute hydrops occurred in both eyes decreasing visual acuity to hand motions bilaterally. Left corneal perforation due to ongoing habit of eyeball pressure was experienced which led the loss of light perception and phtisis bulbi. Although Tourette syndrome is rare, it might cause bilateral acute onset keratoconus when the repetitive movements affect periocular region. Psychiatric treatment should be considered as early as possible in these patients in order to prevent unfavorable complications.
Bulletin of Clinical Psychopharmacology, 2006
onlinemakale.dusunenadamdergisi. …
... Sharma ve arkadaşlarının (2003) ça-lışmasında klozapinin sözel akıcılık, sözel öğrenme, sözel... more ... Sharma ve arkadaşlarının (2003) ça-lışmasında klozapinin sözel akıcılık, sözel öğrenme, sözel ve görsel bellek alanlarında düzelme sağladığı ... Yüksek 5-HT2A reseptör affinitesi olan ati-pik antipsikotiklerle tedavi edilen hastalarda görsel tanıma belleği ve planlama yetisi ...
Son yıllarda yeni ilaçların geliştirilmesi ile şizofreni tedavisinde büyük gelişmeler sağlanmış, ... more Son yıllarda yeni ilaçların geliştirilmesi ile şizofreni tedavisinde büyük gelişmeler sağlanmış, daha önce sorun yaratan ekstrapiramidal yan etkiler ve negatif belirtiler daha iyi kontrol edilebilmiştir. Ancak, yeni antipsikotiklerin çoğu reseptör profillerindeki farklılıklar nedeniyle metabolik yan etkilere sahiptir. Daha kolay başa çıkılan obezite, atipik antipsikotiklerin yaygın olarak kullanıma girmesiyle ilaç almayan ya da tipik antipsikotik kullanan şizofreni hastalarında ciddi bir soruna dönüşmüştür. Obezite, bu hastaların gerek bedensel sağlıklarını, gerekse yaşam kalitesi ve ilaç uyumlarını etkilemektedir. Bu yazıda, şizofreninin doğal gidişi sırasında hasta ilaç almasa bile ortaya çıkan kilo değişiklikleri üzerinde durulduktan sonra, öncelikle obezitenin meydana geliş düzeneği, özellikle leptin, serotoninerjik, adrenerjik ve dopaminerjik sistemler ve en önemlisi histaminerjik sistem incelenmektedir. Ardından şizofreni hastalarında meydana gelen obezitenin tedavi süresi, do...
Anadolu psikiyatri dergisi, 2003
... prevalansı ve depresyon şiddeti ile risk faktörleri arasındaki ilişki Bülent KAYAHAN,1 Ender ... more ... prevalansı ve depresyon şiddeti ile risk faktörleri arasındaki ilişki Bülent KAYAHAN,1 Ender ALTINTOPRAK,1 Sürel KARABİLGİN,2 Özgür ÖZTÜRK1 _____ ...
European Neuropsychopharmacology, 2016
S53 differences between neutral and sad mood with baseline cognitive reactivity and rumination sc... more S53 differences between neutral and sad mood with baseline cognitive reactivity and rumination scores. Results: After sad vs. neutral-mood-induction, remitted MDD patients showed attenuated connectivity between the posterior DMN and the hippocampus; posterior DMNhippocampal connectivity was increased in controls, but not in remitted-MDD patients. Increased hippocampal connectivity was associated with lower levels of cognitive reactivity (r = −21, p = 0.046) and rumination (r = −27, p = 0.017). No effects of sad versus neutral mood-induction were observed in the anterior-DMN, salience-or central executive networks. Conclusion: We showed that in un-medicated MDDpatients in remission, there was attenuated posterior-DMN-connectivity with the hippocampus after sad autobiographical recall. This attenuated connectivity was associated with postulated risk-factors for recurrence; rumination and CR. We interpret our findings in the perspective of over-general autobiographical memory processing in remitted-MDD, where remitted-MDD remember less detailed, more generic memories, with rumination as an underlying factor4. This study adds to evidence pointing to the DMN as an important neural network that is persistently dysfunctional during remission in the presence of stressful triggers. Future studies should assess whether attenuated hippocampus connectivity after sad autobiographical recall is predictive of recurrence.
PubMed, 2005
Schizophrenia and obsesive compulsive disorder (OCD) are among the oldest described psychiatric d... more Schizophrenia and obsesive compulsive disorder (OCD) are among the oldest described psychiatric disorders. Although they appear to be two distinct psychiatric disorders, early literature about the existence of obsessive-compulsive symptoms in schizophrenia dates back to the 1920's. The findings that atypical antipsychotics exacerbate obsessive-compulsive symptoms among schizophrenic patients and the emergence of a possible biological relation between the two diseases increased interest in this subject. Until the 1990's information about the aetiology of obsessive-compulsive symptoms which are observed in about 60% of schizophrenic patients, was insufficient. Recently there has been progress in explaining the structural and functional abnormalities in both OCD and schizophrenia. Knowledge of the cortico-subcortical circuits might explain the co-incidence of symptomatology in the two disorders. It is shown that there is prefrontal cortex dysfunction in both disorders but the bases of dysfunctions are distinct from each other. These dyfunctions derive from two different neuro-anatomical systems partially connected with each other and with different neuro-anatomical connections. It is suggested that dorsolateral prefrontal cortex (DLPC) dysfunction occurs in schizophrenia and ventro-medial prefrontal cortex dysfunction (VMPC) in OCD. In this review, the incidence of obsessive-compulsive symptoms in schizophrenia, their effect on the disorder, the features of the schizo-obsessive patient group and the mechanism of how atypical antipsychotics exacerbate obsessive compulsive symptoms are discussed. Thus, we aimed to highlight the neurobiologic heterogeneity and phenomenology of schizophrenic disorder.
Psychiatry and Clinical Neurosciences, Jun 1, 2005
Obsessive-compulsive symptoms (OCS) have been observed in a substantial proportion of schizophren... more Obsessive-compulsive symptoms (OCS) have been observed in a substantial proportion of schizophrenic patients. In this study, the rate of occurrence of OCS and obsessive-compulsive disorder (OCD) in schizophrenic patients, and also the interrelationship between OCS and schizophrenic symptoms and depressive symptoms were assessed. A total of 100 subjects with a diagnosis of schizophrenia from the 4th edition of the Diagnostic and Statistical Manual (DSM-IV) were evaluated by the structured and clinical interview for axis-1 DSM-IV disorders-patient edition (SCID-P), the Positive and Negative Syndrome Scale (PANSS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and the Calgary Depression Rating Scale for Schizophrenia. The prevalance of OCS in individuals meeting criteria for schizophrenia was 64%. A total of 30 of these patients (Y-BOCS total score > or =7) also met the DSM-IV criteria for OCD. The total score on Y-BOCS was significantly correlated with total score on PANSS, Positive-PANSS score, General-PANSS score and total score on Calgary Depression Rating Scale for Schizophrenia. OCS and OCD relatively frequent in schizophrenic patients and OCS are significantly correlated with the severity of psychosis, positive symptoms, and depressive symptoms in schizophrenic patients. These findings provide further evidence for the importance of OCS in schizophrenia.
Neurology Psychiatry and Brain Research, Aug 1, 2013
Abstract Introduction Schizophrenia is a complex neuropsychiatric disorder with deficits of multi... more Abstract Introduction Schizophrenia is a complex neuropsychiatric disorder with deficits of multiple domains of cognitive functions, volition and emotions. Family and twin studies have provided cumulative evidence for the genetic basis of schizophrenia. The aetiolgy of this disease involves the interplay of multifactiorial inheritance operating on brain maturational processes and polygenic inheritance with some genes showing susceptibility at many genomic locations such as 22q and 11q. The catechol-O-methyltransferase (COMT-22q11) is an extensively studied candidate gene for schizophrenia. COMT acts as an enzymatic detoxicating barrier between the blood and other tissues regulating the amounts of active dopamine and norepinephrine in various parts of the brain and therefore to be associated with schizophrenia. The presence of a common functional single nucleotide polymorphism (SNP) in exon 4 [Guanine (G) Adenine (A); Val108/158Met], alters the enzymatic activity with a trimodal distribution of high-HH, intermediate-HL and low-LL activity alleles which appear to have association with schizophrenia. Brain-derived neurotrophic factor (BDNF-11q13) is a member of the nerve growth factor family working as a molecular regulator of neuronal development and plasticity. Molecules that are critical in the development and survival of neurons such as BDNF play a significant role in the neuropathology of schizophrenia. While upregulation of BDNF increases the neuronal cell size and synaptic plasticity, a functional polymorphism at codon 66 [G→A; Val66Met] down regulates this process and induces schizophrenia. Objective In the present study, our aim was to investigate the differences in allele frequencies between schizophrenic patients [n = 97 (51 men, 46 women)] and control group [n = 376 (228 men, 148 women)] subjects. Results When the control and schizophrenia groups were compared for BDNFVal66Met polymorphism, we did not find a significant difference between the study groups either for genotype (χ2 = 3.370447, p > 0.05) or Val/Met haplotype analysis (χ2 = 2.840264, p > 0.05). When a comparison was revealed for COMT-Val108/158Met polymorphism, no significant difference was detected among schizophrenia and control groups for genotype (χ2 = 0.373330, p > 0.05) and Val/Met haplotype analysis (χ2 = 0.339073, p > 0.05). When the control and study groups were compared for BDNFVal66Met–COMTVal108/158Met polymorphisms compound genotype and haplotype analyses, there was no significant difference between the two groups (χ2 = 11.015; p > 0.05 and χ2 = 3.191; p > 0.05), respectively. Conclusion Our results indicate that there is no association between schizophrenia and BDNF–COMT polymorphisms and haplotypes analysis. We also did not find an association between schizophrenia and BDNF–COMT compound genotype and haplotype analyses. Although our study is unique in Turkey as combining BDNF and COMT compound genotype–haplotype analyses, for a generalization of Turkish schizophrenia patient's susceptibility to schizophrenia; we need further studies with an enlarged cohort.
Anadolu psikiyatri dergisi, 2013
Objective: The neurotrophine 'brain derived neurotrophic factor' (BDNF) which is expressed in the... more Objective: The neurotrophine 'brain derived neurotrophic factor' (BDNF) which is expressed in the brain is responsible for neuronal survive and functioning also plays a role in pathophysiology of alcohol dependence that show multifactorial and polygenic heredity. In the current study, we aimed to define the frequency of the functional Val66Met [G196A; (rs6265)] polymorphism of BDNF gene for Turkish male and female alcohol dependent cases and also to identify whether this polymorphism had any effect upon tendency to alcoholism. Methods: Genotype distribution and allele frequency of BDNF Val66Met polymorphism was identified via PCR-RFLP (Polymerase
Psychiatry and Clinical Psychopharmacology, 2017
Melatonin is an indoleamine often used in children and adolescents. Melatonin is considered to be... more Melatonin is an indoleamine often used in children and adolescents. Melatonin is considered to be an effective clinical management for dyssomnias, sleep disorders present in children with attention-deficit hyperactivity, autism spectrum disorders, developmental delays. Quickacting capsules, controlled-release (CR) capsules, sublingual tablets and liquid forms are available. Melatonin is generally very well-tolerated in children and adolescents. The pharmacology, therapeutic applications, and side effects of melatonin are discussed.
Anadolu Psikiyatri …, 2006
With the development of novel drugs, we have seen a significant improvement in the treatment of s... more With the development of novel drugs, we have seen a significant improvement in the treatment of schizophrenia and have been able to control negative symptoms and extropyramidal side effects. Unfortunately, most of the novel antipsychotics have metabolic side effects, ...
European Psychiatry, Mar 1, 2016
Introduction Social environment may lead to emergence and persistence of psychotic experiences. O... more Introduction Social environment may lead to emergence and persistence of psychotic experiences. Objectives Testing differential impact of social environments on emergence and persistence of subclinical psychotic experiences. Aims To assess different social environments that predicts emergence and persistence of subclinical psychotic experiences in a 6-year follow-up of a representative general population sample. Methods A longitudinal prospective cohort study (the TurkSch - The Izmir Mental Health Survey for Gene-Environment in Psychoses) was conducted with a general population sample ( n =4011) from Izmir-Turkey, who were 15-64 years of age at baseline. Sociodemographic factors, social environmental exposures (deprivation and social capital of neighbourhoods, and familial dysfunction and relationships), and measures of psychopathology (subclinical psychotic experiences) were assessed across two waves (T 1 -2008 and T 2 -2014; n =2192) using the Composite International Diagnostic Interview. Results Measures of wider social environment at T 1 (high social control and social deprivation within neighbourhoods) was associated with emergence (OR=1.6; 95% CI=0.6-2.4) and persistence (OR=1.8; 95% CI=0.6-2.4) of psychotic experiences at T 2 . Also, measures of familial dysfunction and relationships were associated with emergence (OR=2.1; 95% CI=1.2-3.3) and persistence (OR=3.3; 95% CI=1.4-6.7) at T 2 . The associations between wider social environment and psychotic experiences were not significant after adjusting for measures of family dysfunction relationship. Conclusions The association between wider social environment and psychosis may be partially a result of dysfunctional relationships within the narrow environment including family. Current and past difficult family relationships may be an important contributing factor.
Comprehensive psychiatry, 2012
Although obsessive-compulsive symptoms are not considered primary features, they are prevalent, i... more Although obsessive-compulsive symptoms are not considered primary features, they are prevalent, independent of psychosis, and substantially modify clinical characteristics, course, treatment and prognosis of schizophrenia. The authors highlight the clinical significance of obsessive-compulsive symptoms in schizophrenia, provide diagnostic criteria for "schizo-obsessive" patients and address future directions for research.
European Psychiatry, 2016
Introduction Subthreshold depression is prevalent in general population and is associated with po... more Introduction Subthreshold depression is prevalent in general population and is associated with poorer quality of life, higher health care use and increased risk of mental disorders mainly depression. Objectives Testing predictive impact of subthreshold depression on emergence and persistence of subclinical psychotic experiences. Aims To assess association between subthreshold depression and persistence of subclinical psychotic experiences in a 6-year follow-up of a representative general population sample. Methods A longitudinal prospective cohort study (the TurkSch The Izmir Mental Health Survey for Gene–Environment in Psychoses) was conducted with a general population sample ( n =4011) from Izmir, Turkey, who were 15–64 years of age at baseline. Sociodemographic factors, subthreshold depression (based on responses to systematic screening questions of the relevant questions with having less than five symptoms or having symptoms less than two weeks or having non-interfering impairme...
European Neuropsychopharmacology, 2017
23rd Annual World Congress of Psychiatric Genetics (WCPG) -- OCT 16-20, 2015 -- Toronto, CANADAWO... more 23rd Annual World Congress of Psychiatric Genetics (WCPG) -- OCT 16-20, 2015 -- Toronto, CANADAWOS: 00041384380018
Saudi Journal of Ophthalmology, 2018
A 27-year-old male with a repetitive behavior of eyeball pressing for six months presented with d... more A 27-year-old male with a repetitive behavior of eyeball pressing for six months presented with decreasing visual acuity for three months. Upon arrival his best corrected visual acuity was 0.2 on the right and 0.6 on the left eyes. Scheimpflug camera system demonstrated grade 4 and grade 2 keratoconus, respectively. Psychiatric consultation revealed Tourette syndrome and treatment was started. Despite psychiatric treatment, acute hydrops occurred in both eyes decreasing visual acuity to hand motions bilaterally. Left corneal perforation due to ongoing habit of eyeball pressure was experienced which led the loss of light perception and phtisis bulbi. Although Tourette syndrome is rare, it might cause bilateral acute onset keratoconus when the repetitive movements affect periocular region. Psychiatric treatment should be considered as early as possible in these patients in order to prevent unfavorable complications.
Bulletin of Clinical Psychopharmacology, 2006
onlinemakale.dusunenadamdergisi. …
... Sharma ve arkadaşlarının (2003) ça-lışmasında klozapinin sözel akıcılık, sözel öğrenme, sözel... more ... Sharma ve arkadaşlarının (2003) ça-lışmasında klozapinin sözel akıcılık, sözel öğrenme, sözel ve görsel bellek alanlarında düzelme sağladığı ... Yüksek 5-HT2A reseptör affinitesi olan ati-pik antipsikotiklerle tedavi edilen hastalarda görsel tanıma belleği ve planlama yetisi ...
Son yıllarda yeni ilaçların geliştirilmesi ile şizofreni tedavisinde büyük gelişmeler sağlanmış, ... more Son yıllarda yeni ilaçların geliştirilmesi ile şizofreni tedavisinde büyük gelişmeler sağlanmış, daha önce sorun yaratan ekstrapiramidal yan etkiler ve negatif belirtiler daha iyi kontrol edilebilmiştir. Ancak, yeni antipsikotiklerin çoğu reseptör profillerindeki farklılıklar nedeniyle metabolik yan etkilere sahiptir. Daha kolay başa çıkılan obezite, atipik antipsikotiklerin yaygın olarak kullanıma girmesiyle ilaç almayan ya da tipik antipsikotik kullanan şizofreni hastalarında ciddi bir soruna dönüşmüştür. Obezite, bu hastaların gerek bedensel sağlıklarını, gerekse yaşam kalitesi ve ilaç uyumlarını etkilemektedir. Bu yazıda, şizofreninin doğal gidişi sırasında hasta ilaç almasa bile ortaya çıkan kilo değişiklikleri üzerinde durulduktan sonra, öncelikle obezitenin meydana geliş düzeneği, özellikle leptin, serotoninerjik, adrenerjik ve dopaminerjik sistemler ve en önemlisi histaminerjik sistem incelenmektedir. Ardından şizofreni hastalarında meydana gelen obezitenin tedavi süresi, do...
Anadolu psikiyatri dergisi, 2003
... prevalansı ve depresyon şiddeti ile risk faktörleri arasındaki ilişki Bülent KAYAHAN,1 Ender ... more ... prevalansı ve depresyon şiddeti ile risk faktörleri arasındaki ilişki Bülent KAYAHAN,1 Ender ALTINTOPRAK,1 Sürel KARABİLGİN,2 Özgür ÖZTÜRK1 _____ ...
European Neuropsychopharmacology, 2016
S53 differences between neutral and sad mood with baseline cognitive reactivity and rumination sc... more S53 differences between neutral and sad mood with baseline cognitive reactivity and rumination scores. Results: After sad vs. neutral-mood-induction, remitted MDD patients showed attenuated connectivity between the posterior DMN and the hippocampus; posterior DMNhippocampal connectivity was increased in controls, but not in remitted-MDD patients. Increased hippocampal connectivity was associated with lower levels of cognitive reactivity (r = −21, p = 0.046) and rumination (r = −27, p = 0.017). No effects of sad versus neutral mood-induction were observed in the anterior-DMN, salience-or central executive networks. Conclusion: We showed that in un-medicated MDDpatients in remission, there was attenuated posterior-DMN-connectivity with the hippocampus after sad autobiographical recall. This attenuated connectivity was associated with postulated risk-factors for recurrence; rumination and CR. We interpret our findings in the perspective of over-general autobiographical memory processing in remitted-MDD, where remitted-MDD remember less detailed, more generic memories, with rumination as an underlying factor4. This study adds to evidence pointing to the DMN as an important neural network that is persistently dysfunctional during remission in the presence of stressful triggers. Future studies should assess whether attenuated hippocampus connectivity after sad autobiographical recall is predictive of recurrence.