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senolytic

出典:『Wiktionary』 (2024/08/28 13:57 UTC 版)

名詞

senolytic (plural senolytics)

1. (medicine) Any drug that destroys senescent cells.
   • 2022, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Hang Lin, Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes, Zhen Li, Laura Creemers, Xiaoling Zhang (editors), Regenerative Medicine for Cartilage and Joint Repair, Frontiers in Bioengineering and Biotechnology, page 14,
     Therefore, the treatment with senolytics may not be able to reverse the loss of chondrogenic potential in PDL9.
   • 2023, Arda Küçükgüven, Íbrahim Vargel, 16: Antiaging: Is it possible?, Ibrahim Vargel, Fatma Figen Özgür (editor), Beauty, Aging and AntiAging, Elsevier (Academic Press), page 157,
     It is important to reevaluate the efficacy of these senolytics for long-term use in antiaging, particularly if they were originally developed for short-term use.

形容詞

senolytic (not comparable)

1. (medicine) That destroys senescent cells.
   • 2022, Jacques Ferreira, Alex Deamer, Chapter 13: Clearance of senescent cells: potent anti-aging approach, Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra (editors), Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging, Elsevier (Academic Press), page 299,
     However, fisetin, a quercetin derivative, is moderately senolytic to many cell types, including mesenchyme-derived cells (Sasaki, Sato, & Nakanuma, 2020; Yousefzadeh et al., 2018), despite only differing by a hydroxyl group.

関連する語

• senolysis
• senomorphic
• senostatic
• senotherapy

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