ENZYME - 1.14.16.4 tryptophan 5-monooxygenase (original) (raw)
| Accepted Name | |
|---|---|
| tryptophan 5-monooxygenase | |
| Alternative Name(s) | |
| indoleacetic acid-5-hydroxylase | |
| L-tryptophan hydroxylase | |
| tryptophan 5-hydroxylase | |
| tryptophan hydroxylase | |
| Reaction catalysed | |
| (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin | |
| Comment(s) | |
| Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein kinase.The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96.The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin. | |
| Cross-references | |
| BRENDA | 1.14.16.4 |
| EC2PDB | 1.14.16.4 |
| ExplorEnz | 1.14.16.4 |
| PRIAM enzyme-specific profiles | 1.14.16.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.16.4 |
| IUBMB Enzyme Nomenclature | 1.14.16.4 |
| IntEnz | 1.14.16.4 |
| MEDLINE | Find literature relating to 1.14.16.4 |
| MetaCyc | 1.14.16.4 |
| Rhea expert-curated reactions | 1.14.16.4 |
| UniProtKB/Swiss-Prot | P90925, PH4H_CAEELQ54XS1, PH4H_DICDIP17276, PH4H_DROME P70080, TPH1_CHICKP17752, TPH1_HUMANP17532, TPH1_MOUSE P17290, TPH1_RABITP09810, TPH1_RATQ92142, TPH1_XENLA Q0EAB8, TPH2_HORSEQ8IWU9, TPH2_HUMANQ2HZ26, TPH2_MACMU Q8CGV2, TPH2_MOUSEQ8CGU9, TPH2_RAT |
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