ENZYME - 2.3.1.26 sterol O-acyltransferase (original) (raw)
| Accepted Name | |
|---|---|
| sterol O-acyltransferase | |
| Alternative Name(s) | |
| cholesterol acyltransferase | |
| sterol-ester synthase | |
| Reaction catalysed | |
| a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA | |
| Comment(s) | |
| The enzyme catalyzes the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A.The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA.In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol.In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of 'foam cells', a hallmark of early atherosclerotic lesions.In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell. | |
| Cross-references | |
| BRENDA | 2.3.1.26 |
| EC2PDB | 2.3.1.26 |
| ExplorEnz | 2.3.1.26 |
| PRIAM enzyme-specific profiles | 2.3.1.26 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.26 |
| IUBMB Enzyme Nomenclature | 2.3.1.26 |
| IntEnz | 2.3.1.26 |
| MEDLINE | Find literature relating to 2.3.1.26 |
| MetaCyc | 2.3.1.26 |
| Rhea expert-curated reactions | 2.3.1.26 |
| UniProtKB/Swiss-Prot | O77760, SOAT1_CHLAEQ60457, SOAT1_CRIGRP35610, SOAT1_HUMAN O77761, SOAT1_MACFAQ61263, SOAT1_MOUSEO70536, SOAT1_RAT O77759, SOAT2_CHLAEO75908, SOAT2_HUMANO88908, SOAT2_MOUSE Q7TQM4, SOAT2_RAT |
View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-