The urinary proteome as correlate and predictor of renal function in a population study (original) (raw)
Gu, Y.-M. et al. (2014) The urinary proteome as correlate and predictor of renal function in a population study.Nephrology Dialysis Transplantation, 29(12), pp. 2260-2268. (doi: 10.1093/ndt/gfu234)
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Abstract
Background: We investigate whether the urinary proteome refines the diagnosis of renal dysfunction, which affects over 10% of the adult population.
Methods: We measured serum creatinine, estimated glomerular filtration rate (eGFR) and 24-h albuminuria in 797 people randomly recruited from a population. We applied capillary electrophoresis coupled with mass spectrometry to measure multi-dimensional urinary proteomic classifiers developed for renal dysfunction (CKD273) or left ventricular dysfunction (HF1 and HF2). Renal function was followed up in 621 participants and the incidence of cardiovascular events in the whole study population. Results: In multivariable-adjusted cross-sectional analyses, higher biomarker levels analysed separately or combined by principal component analysis into a single factor (SF), correlated (P ≤ 0.010) with worse renal function. Over 4.8 years, higher HF1 and SF predicted (P ≤ 0.014) lowering of eGFR; higher HF2 predicted (P ≤ 0.049) increase in serum creatinine and decrease eGFR. HF1, HF2 and SF predicted progression from CKD Stages 2 or ≤2 to Stage ≥3, with risk estimates for a 1-SD increment in the urinary biomarkers ranging from 38 to 71% (P ≤ 0.039). HF1, HF2 and SF yielded a net reclassification improvement of 31–51% (P ≤ 0.029). Over 6.1 years, 47 cardiovascular events occurred. HF2 and SF, independent of baseline eGFR, 24-h albuminuria and other covariables were significant predictors of cardiovascular complications with risk estimates for 1-SD increases ranging from 32 to 41% (P ≤ 0.047). Conclusions: The urinary proteome refines the diagnosis of existing or progressing renal dysfunction and predicts cardiovascular complications.| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mischak, Professor Harald and Delles, Professor Christian |
| Authors: | Gu, Y.-M., Thijs, L., Liu, Y.-P., Zhang, Z., Jacobs, L., Koeck, T., Zurbig, P., Lichtinghagen, R., Brand, K., Kuznetsova, T., Olivi, L., Verhamme, P., Delles, C., Mischak, H., and Staessen, J. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Nephrology Dialysis Transplantation |
| Publisher: | Oxford University Press |
| ISSN: | 0931-0509 |
| ISSN (Online): | 1460-2385 |
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Funder and Project Information
1
HOMAGE: Heart OMics in AGEing
Christian Delles
305507
RI CARDIOVASCULAR & MEDICAL SCIENCES
Deposit and Record Details
| ID Code: | 101043 |
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| Depositing User: | Miss Fiona Doyle |
| Datestamp: | 15 Jan 2015 14:26 |
| Last Modified: | 02 May 2025 04:34 |
| Date of first online publication: | 2014 |