Cell material interactions (original) (raw)

Tsimbouri, Penelope M. ORCID: https://orcid.org/0000-0001-5124-7458, McNamara, Laura E., Alakpa, Enateri V., Dalby, Matthew J. ORCID: https://orcid.org/0000-0002-0528-3359 and Turner, Lesley-Anne(2015) Cell material interactions. In: van Blitterswijk, Clemens A. and de Boer, Jan (eds.)Tissue Engineering. Elsevier, pp. 217-251. ISBN 9780124202108(doi: 10.1016/B978-0-12-420145-3.00007-9)

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Abstract

Cells can interpret information from their extracellular environment by turning physical cues into biochemical signals (mechanotransduction). Such physical cues may be in the form of surface chemistry (inherent or grafted), topography (macro, micro, or nanoscale in size) and stiffness (tissues have varying hardness from soft fat or nerve tissue to hard bone tissue). Using cell adhesion sites, cells alter their adhesion and cytoskeleton in response to these extracellular cues. Adhesions and the cytoskeleton are intimately linked to biochemical effectors that can elicit control over cell migration, growth and even stem cell self-renewal and differentiation. This chapter will explore how we can use synthetic materials to explore the cell–material interface and how this has implications for tissue engineering next-generation scaffolds.

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