Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial (original) (raw)

Mullan, Adam, Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Ferrell, William, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Edwards, Christine A. ORCID: https://orcid.org/0000-0003-0406-918X, McColl, John H. ORCID: https://orcid.org/0000-0002-6008-2349, Roberts, Susan A. and Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083(2016) Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial.Atherosclerosis, 246, pp. 169-176. (doi: 10.1016/j.atherosclerosis.2016.01.004) (PMID:26797134)

Abstract

Objective: To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical co-morbidity in a randomized placebo controlled pilot study. Methods: Randomly assigned active 250 ml beverages containing 361 mg of (poly)phenols and 120 mg of vitamin C or placebo (no polyphenol/vitamin C) were taken twice daily for 4 weeks. Both beverages contained 40 kcals/250 ml. The primary end-points were pulse wave velocity (PWV) and cutaneous microvascular responses to sodium nitroprusside (SNP) and acetyl choline (ACh) laser doppler iontophoresis. A range of established and novel plasma markers were also measured. Results: Twenty subjects received active beverage and 19 placebo; all completed the study. There was no difference in cutaneous vascular response to either SNP or ACh with mean group differences (logD area under perfusion curve) of 0.30 (0.65, 1.26) and 0.35 (0.11, 0.81) respectively. Nor was there evidence of a change in log PWV with a mean group difference of 0.029 m/s (0.042, 0.10). No significant differences were seen in plasma leptin, apolipoproteins, cystatin C, insulin, adiponectin, CRP, ICAM-1, E-Selectin or tPA, but IL-6 increased in active versus placebo recipients (0.32 vs e 0.18 pg/ml; p ¼ 0.010). Conculsion: There was no evidence for a short-term beneficial effect of (poly)phenol intervention on microcutaneous vascular response or pulse wave velocity, and no evidence for a benefit on established or novel risk factors in overweight or obese subjects. Our results do not support a short-term benefit of (poly)phenol supplementation on cardiometabolic risk.

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