ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis (original) (raw)

Perrella, Giorgio, Davidson, Mhairi L.H., O'Donnell, Liz ORCID: https://orcid.org/0000-0003-3330-3879, Nastase, Ana-Maria, Herzyk, Pawel ORCID: https://orcid.org/0000-0002-7439-292X, Breton, Ghislain, Pruneda-Paz, Jose L., Kay, Steve A., Chory, Joanne and Kaiserli, Eirini ORCID: https://orcid.org/0000-0003-1517-4591(2018) ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America, 115(19), E4503-E4511. (doi: 10.1073/pnas.1718099115) (PMID:29686058) (PMCID:PMC5948964)

Abstract

Integration of environmental signals and interactions among photoreceptors and transcriptional regulators is key in shaping plant development. TANDEM ZINC-FINGER PLUS3 (TZP) is an integrator of light and photoperiodic signaling that promotes flowering in Arabidopsis thaliana. Here we elucidate the molecular role of TZP as a positive regulator of hypocotyl elongation. We identify an interacting partner for TZP, the transcription factor ZINC-FINGER HOMEODOMAIN 10 (ZFHD10), and characterize its function in coregulating the expression of blue-light–dependent transcriptional regulators and growth-promoting genes. By employing a genome-wide approach, we reveal that ZFHD10 and TZP coassociate with promoter targets enriched in light-regulated elements. Furthermore, using a targeted approach, we show that ZFHD10 recruits TZP to the promoters of key coregulated genes. Our findings not only unveil the mechanism of TZP action in promoting hypocotyl elongation at the transcriptional level but also assign a function to an uncharacterized member of the ZFHD transcription factor family in promoting plant growth.

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Funder and Project Information

1

Transcriptional regulation of plant growth in nuclear microdomains

Eirini Kaiserli

BB/M023079/1

RI MOLECULAR CELL & SYSTEMS BIOLOGY

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