Chemokine transport dynamics and emerging recognition of their role in immune function (original) (raw)

Moore, James E., Brook, Bindi S. and Nibbs, Robert J.B. ORCID: https://orcid.org/0000-0002-8150-0044(2018) Chemokine transport dynamics and emerging recognition of their role in immune function.Current Opinion in Biomedical Engineering, 5, pp. 90-95. 30320240. (doi: 10.1016/j.cobme.2018.03.001) (PMID:PMC6176735)

Abstract

Leukocyte migration is critically important during all protective and pathological immune and inflammatory responses. Chemokines play fundamental roles in this process, and chemokine concentration gradients stimulate the directional migration of leukocytes. The formation and regulation of these gradients is poorly understood. These are complex processes that depend on the specific properties of each chemokine and interactions between physical, biological and biochemical processes, including production, diffusion, advection, scavenging, post-translational modification, and extracellular matrix (ECM) binding. While some of these mechanisms have been investigated in isolation or limited combinations, more integrative research is required to provide a quantitative knowledge base that explains how chemokine gradients are established and maintained, and how cells respond to, and modify, these gradients.

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Funder and Project Information

0

Integrative Transport Phenomena in Chemokine Gradient Establishment

Robert Nibbs

206284/Z/17/Z

III - Immunology

1

Defining mechanisms that control T cell migration

Simon Milling

MR/N023625/1

III -IMMUNOLOGY

1

The ACKR2-CCR2 axis in development and disease

Gerard Graham

MR/M019764/1

III -IMMUNOLOGY

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