Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix (original) (raw)

Bollopragada, S, Youssef, R, Jordan, F, Greer, I, Norman, JE and Nelson, S ORCID: https://orcid.org/0000-0002-9099-3047(2009) Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix.American Journal of Obstetrics and Gynecology, 200(1), (doi: 10.1016/j.ajog.2008.08.032)

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Abstract

OBJECTIVE: Identify overlap of the transcriptome of myometrium and cervix in association with human labor. STUDY DESIGN: The transcriptional profile of myometrial and cervical biopsies obtained from women in spontaneous labor at term (n = 9) and not in labor (n = 9) were characterized by Affymetrix v2 U133 plus 2 arrays. Common canonical pathways and functional groups were identified by Ingenuity Pathway Analysis. RESULTS: One hundred ten genes (false discovery rate < 1%) were commonly up-regulated by myometrium and cervix in association with labor and 29 genes (false discovery rate < 1%) down-regulated. Fold change in expression of up-regulated genes was strongly correlated; myometrium vs cervix (r = 0.51; P < .001), with no relationship in down-regulated genes (r = 0.26; P = .16). Canonical pathway analysis established up-regulation of inflammatory pathway signaling, with greatest increases in cellular movement and immune response gene ontology groups. CONCLUSION: Gestational tissues exhibit a core inflammatory response in association with human parturition, with pathways regulating cellular trafficking dominating.

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