TRPM7, magnesium and signaling (original) (raw)
Zou, Zhi-Guo, Rios, Francisco J. 
ORCID: https://orcid.org/0000-0002-8194-0787, Montezano, Augusto C. and Touyz, Rhian M. ORCID: https://orcid.org/0000-0003-0670-0887(2019) TRPM7, magnesium and signaling.International Journal of Molecular Sciences, 20(8), 1877. (doi: 10.3390/ijms20081877) (PMID:30995736) (PMCID:PMC6515203)
Abstract
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed chanzyme that possesses an ion channel permeable to the divalent cations Mg2+, Ca2+, and Zn2+, and an α-kinase that phosphorylates downstream substrates. TRPM7 and its homologue TRPM6 have been implicated in a variety of cellular functions and is critically associated with intracellular signaling, including receptor tyrosine kinase (RTK)-mediated pathways. Emerging evidence indicates that growth factors, such as EGF and VEGF, signal through their RTKs, which regulate activity of TRPM6 and TRPM7. TRPM6 is primarily an epithelial-associated channel, while TRPM7 is more ubiquitous. In this review we focus on TRPM7 and its association with growth factors, RTKs, and downstream kinase signaling. We also highlight how interplay between TRPM7, Mg2+ and signaling kinases influences cell function in physiological and pathological conditions, such as cancer and preeclampsia.
| Item Type: | Articles |
|---|---|
| Additional Information: | Funding: R.M.T. is supported by a British Heart Foundation Award (CH/12/429762). A.C.M. is supported through a Walton Fellowship, University of Glasgow. Z.Z. is funded by China Scholarship Council (201708060309). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Montezano, Dr Augusto and Rios, Dr Francisco and Zou, ZhiGuo and Touyz, Professor Rhian |
| Authors: | Zou, Z.-G., Rios, F. J., Montezano, A. C., and Touyz, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | International Journal of Molecular Sciences |
| Publisher: | MDPI |
| ISSN: | 1661-6596 |
| ISSN (Online): | 1422-0067 |
| Published Online: | 16 April 2019 |
| Copyright Holders: | Copyright © 2019 by the authors |
| First Published: | First published in International Journal of Molecular Sciences 20(8):1877 |
| Publisher Policy: | Reproduced under a Creative Commons license |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
0
Vascular Noxs as therapeutic targets and biomarkers in hypertension
Rhian Touyz
CH/12/4/29762
CAMS - Cardiovascular Science
Deposit and Record Details
| ID Code: | 182333 |
|---|---|
| Depositing User: | Ms Jacqui Brannan |
| Datestamp: | 04 Sep 2019 13:48 |
| Last Modified: | 02 May 2025 20:59 |
| Date of acceptance: | 12 April 2019 |
| Date of first online publication: | 16 April 2019 |
| Date Deposited: | 21 March 2019 |