Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: Heterogeneity of responses (original) (raw)

Gill, J.M. ORCID: https://orcid.org/0000-0003-3615-0986, Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Perry, C.G., Sattar, N. ORCID: https://orcid.org/0000-0002-1604-2593, Packard, C.J. ORCID: https://orcid.org/0000-0002-2386-9927, Caslake, M.J. and Petrie, J.R. ORCID: https://orcid.org/0000-0002-4894-9819(2007) Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: Heterogeneity of responses.Atherosclerosis, 194(1), pp. 134-143. (doi: 10.1016/j.atherosclerosis.2006.10.007)

Full text not currently available from Enlighten.

Abstract

Prior moderate exercise has been shown consistently to reduce postprandial triglyceride (TG) concentrations in non-diabetic adults, but its effects in men with type 2 diabetes are not known. This study aimed to determine the effect of moderate exercise on postprandial metabolism in men with type 2 diabetes. Ten middle-aged men with type 2 diabetes underwent two oral fat tolerance tests (blood taken fasting and for 8 h after a meal containing 80 g fat, 70 g carbohydrate) in random order. On the afternoon before one test, participants performed a 90-min treadmill walk (Exercise); no exercise was performed before the Control test. Exercise significantly reduced fasting glucose (Control: 9.08 ± 0.75 mmol l−1, Exercise: 8.40 ± 0.72 mmol l−1, p = 0.033) and insulin (Control: 8.01 ± 0.98 μU ml−1, Exercise: 6.81 ± 0.93 μU ml−1, p = 0.046) and increased fasting 3-hydroxybutyrate (Control: 87.1 ± 19.2 μmol l−1, Exercise: 134.3 ± 28.4 μmol l−1, p = 0.011); reduced postprandial insulin by 11.0% (p = 0.04) and increased postprandial 3-hydroxybutrate by 31.8% (p = 0.03); but did not significantly change fasting or postprandial triglyceride or NEFA concentrations. However, the exercise-induced change in postprandial triglyceride concentration ranged from −32.3 to +28.3% and the exercise-induced change in fasting 3-hydroxybutyrate concentration (a marker of hepatic fatty acid oxidation) was highly correlated with the exercise-induced changes in fasting and postprandial triglyceride (r = 0.68, p = 0.03 for both). Thus, inter-individual variation in propensity to increase hepatic fatty acid oxidation following exercise may account for the considerable heterogeneity in triglyceride responses to moderate exercise observed in men with type 2 diabetes.

University Staff: Request a correction | Enlighten Editors: Update this record

Deposit and Record Details