Overview of dopamine transporter imaging in Parkinson's disease, dementia with lewy bodies and other dementias (original) (raw)

Malek, Naveed and Grosset, Donald G. ORCID: https://orcid.org/0000-0002-2757-8203(2015) Overview of dopamine transporter imaging in Parkinson's disease, dementia with lewy bodies and other dementias.Current Geriatrics Reports, 4(2), pp. 124-130. (doi: 10.1007/s13670-015-0126-9)

Full text not currently available from Enlighten.

Abstract

123I FP-CIT is a radiotracer that is used in conjunction with single photon emission computed tomography (SPECT) scanning to detect dopaminergic neuron pre-synaptic terminal degeneration, in the striatum (caudate nucleus and putamen) of patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), showing a reduced uptake of this ligand by the dopamine transporters (DaT). This is a licensed diagnostic test in Europe (as DaTSCAN) and in the USA (as DaTscan). Recent work on functional imaging in PD and DLB largely uses the FP-CIT SPECT approach, and this is the focus of our paper, whilst noting that other ligands (e.g. beta-CIT) and imaging techniques such as positron emission tomography (PET) have been used in similar settings.

University Staff: Request a correction | Enlighten Editors: Update this record

Deposit and Record Details