Notch3 signaling and vascular remodeling in pulmonary arterial hypertension (original) (raw)
Morris, Hannah, Neves, Karla B. 
ORCID: https://orcid.org/0000-0001-5158-9263, Montezano, Augusto C., Maclean, Margaret R. and Touyz, Rhian ORCID: https://orcid.org/0000-0003-0670-0887(2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension.Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)
Abstract
Notch signalling is critically involved in vascular morphogenesis and function. Four Notch isoforms (Notch1–4) regulating diverse cellular processes have been identified. Of these, Notch3 is expressed almost exclusively in vascular smooth muscle cells (VSMCs), where it is critically involved in vascular development and differentiation. Under pathological conditions, Notch3 regulates VSMC switching between the contractile and synthetic phenotypes. Abnormal Notch3 signalling plays an important role in vascular remodelling, a hallmark of several cardiovascular diseases, including pulmonary arterial hypertension (PAH). Because of the importance of Notch3 in VSMC (de)differentiation, Notch3 has been implicated in the pathophysiology of pulmonary vascular remodelling in PAH. Here we review the current literature on the role of Notch in VSMC function with a focus on Notch3 signalling in pulmonary artery VSMCs, and discuss potential implications in pulmonary artery remodelling in PAH.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the MRC Fellowship [grant number MR/R502327/1 (to H.E.M.)]; the British Heart Foundation [grant numbers CH/12/429762, RE/13/5/30177 (to R.M.T.)]; the Walton Fellowship, University of Glasgow (to A.C.M.); and the British Heart Foundation [grant number RG/16/2/32153 (to M.R.M.)]. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Touyz, Professor Rhian and Morris, Hannah and Neves, Dr Karla and Montezano, Dr Augusto |
| Authors: | Morris, H., Neves, K. B., Montezano, A. C., Maclean, M. R., and Touyz, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Clinical Science |
| Publisher: | Portland Press on behalf of the Biochemical Society |
| ISSN: | 0143-5221 |
| ISSN (Online): | 1470-8736 |
| Copyright Holders: | Copyright © 2019 The Author(s) |
| First Published: | First published in Clinical Science 133(24):2481-2498 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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Funder and Project Information
Vascular Noxs as therapeutic targets and biomarkers in hypertension
Rhian Touyz
CH/12/4/29762
Institute of Cardiovascular & Medical Sciences
BHF centre of excellence
Rhian Touyz
RE/13/5/30177
Institute of Cardiovascular & Medical Sciences
Deposit and Record Details
| ID Code: | 205628 |
|---|---|
| Depositing User: | Dr Mary Donaldson |
| Datestamp: | 13 Dec 2019 12:10 |
| Last Modified: | 02 May 2025 06:21 |
| Date of acceptance: | 11 December 2019 |
| Date of first online publication: | 23 December 2019 |
| Date Deposited: | 13 December 2019 |
| Data Availability Statement: | No |