Metabolic and inflammatory functions of short-chain fatty acid receptors (original) (raw)
Bolognini, Daniele, Dedeo, Domonkos 
ORCID: https://orcid.org/0000-0003-3796-1713 and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2021) Metabolic and inflammatory functions of short-chain fatty acid receptors.Current Opinion in Endocrine and Metabolic Research, 16, pp. 1-9. (doi: 10.1016/j.coemr.2020.06.005) (PMID:32835130) (PMCID:PMC7332907)
Abstract
FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the production and use of novel pharmacological tools and animal models. A complex (patho)physiological scenario is now emerging in which strategic expression of FFA2 and FFA3 in key cell types and selective modulation of their signalling might regulate body weight management, energy homoeostasis and inflammatory disorders.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Bolognini, Dr Daniele and Milligan, Professor Graeme and Dedeo, Dr Domonkos |
| Authors: | Bolognini, D., Dedeo, D., and Milligan, G. |
| College/School: | College of Medical Veterinary and Life SciencesCollege of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Current Opinion in Endocrine and Metabolic Research |
| Publisher: | Elsevier |
| ISSN: | 2451-9650 |
| ISSN (Online): | 2451-9650 |
| Published Online: | 03 July 2020 |
| Copyright Holders: | Copyright © 2020 The Authors |
| First Published: | First published in Current Opinion in Endocrine and Metabolic Research 16:1-9 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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