PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study (original) (raw)
Lyall, Donald M. 
ORCID: https://orcid.org/0000-0003-3850-1487, Ward, Joey ORCID: https://orcid.org/0000-0003-0951-8511, Banach, Maciej, Smith, George Davey, Gill, Jason G. ORCID: https://orcid.org/0000-0003-3615-0986, Pell, Jill P. ORCID: https://orcid.org/0000-0002-8898-7035, Holmes, Michael V. and Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593(2021) PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study.Archives of Medical Science, 17(1), pp. 241-244. (doi: 10.5114/aoms/127226)
Abstract
Introduction: PCSK9 inhibitors lower low-density lipoprotein (LDL) cholesterol and are efficacious at reducing vascular disease, however questions remain about potential effects on cognitive function. Methods: We examined the association of genetic variants in PCSK9 with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in PCSK9 were used in up to 337,348 individuals. Results: The PCSK9 allele score was associated with a lower risk of CHD, and weakly with worse log reaction time. Conclusions: We are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ward, Dr Joey and Gill, Professor Jason and Pell, Professor Jill and Sattar, Professor Naveed and Lyall, Dr Donald |
| Authors: | Lyall, D. M., Ward, J., Banach, M., Smith, G. D., Gill, J. G., Pell, J. P., Holmes, M. V., and Sattar, N. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic HealthCollege of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
| Journal Name: | Archives of Medical Science |
| Publisher: | Termedia |
| ISSN: | 1734-1922 |
| ISSN (Online): | 1896-9151 |
| Copyright Holders: | Copyright © 2020 Termedia & Banach |
| First Published: | First published in Archives of Medical Science 17(1):241–244 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
| ID Code: | 222866 |
|---|---|
| Depositing User: | Dr Aniko Szilagyi |
| Datestamp: | 04 Sep 2020 13:39 |
| Last Modified: | 03 Mar 2022 16:13 |
| Date of acceptance: | 3 September 2020 |
| Date of first online publication: | 5 January 2021 |
| Date Deposited: | 4 September 2020 |
| Data Availability Statement: | No |