Tumor size is associated with the systemic inflammatory response but not survival in patients with primary operable colorectal cancer (original) (raw)

Crozier, J.E., McMillan, D.C., McArdle, C.S., Angerson, W.J., Anderson, J.H., Horgan, P. and McKee, R.F.(2007) Tumor size is associated with the systemic inflammatory response but not survival in patients with primary operable colorectal cancer.Journal of Gastroenterology and Hepatology, 22(12), pp. 2288-2291. (doi: 10.1111/j.1440-1746.2006.04792.x)

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Abstract

AIM: To examine the relationship between tumor diameter, C-reactive protein concentrations and survival in patients undergoing surgery for colorectal cancer.

METHOD: Tumor diameter and pathological characteristics of the resected specimen were assessed in 227 patients. Circulating concentrations of C-reactive protein were measured prior to surgery.

RESULTS: Ninety-six patients had an elevated C-reactive protein concentration (>10 mg/L) prior to surgery. Tumor size was associated with an elevated C-reactive protein concentration (P < 0.001). C-reactive protein concentrations (P < 0.001) were associated with poorer cancer-specific survival.

CONCLUSION: Prior to surgery, the maximal tumor diameter is associated with an elevated preoperative C-reactive protein concentration but not survival in patients with primary operable colorectal cancer.

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